Re: Glucomannan (Konjac Root)

[Guest guest]

Dr Oz talked about it last year.

S. Nodvin MS, RD/LD

CWO, Lifeally, Inc.

112 Krog Street, #7

Atlanta‎ GA‎ 30307

(404) 414.1112

I had an outpatient come in today asking about this supplement. Does anyone

know anything about it or can you point me to a reputable website to learn

more? It is supposed to promote wt loss, like Lipozene (advertised on TV).

thanks.

Kristy Heussner, MS, RD, LD

[Guest guest]

Here is what I got off the natural medicines database:

Also Known As:

[cid:image001.gif@...]<http://naturaldatabase.therapeuticresearch.\

com/nd/Search.aspx?cs=ONDPG & s=ND & pt=100 & id=205 & fs=ND & searchid=36481385#top>

Glucomanano, Glucomannane, Konjac, Konjac Mannan.

Scientific Name:

[cid:image001.gif@...]<http://naturaldatabase.therapeuticresearch.\

com/nd/Search.aspx?cs=ONDPG & s=ND & pt=100 & id=205 & fs=ND & searchid=36481385#top>

Amorphophallus konjac, synonym Amorphophallus rivieri.

Family: Araceae.

People Use This For:

[cid:image001.gif@...]<http://naturaldatabase.therapeuticresearch.\

com/nd/Search.aspx?cs=ONDPG & s=ND & pt=100 & id=205 & fs=ND & searchid=36481385#top>

Orally, glucomannan is used for constipation, weight loss in adults and

children, type 2 diabetes, blood glucose control, and reducing serum

cholesterol.

In foods, glucomannan is used in food preparation.

Safety:

[cid:image001.gif@...]<http://naturaldatabase.therapeuticresearch.\

com/nd/Search.aspx?cs=ONDPG & s=ND & pt=100 & id=205 & fs=ND & searchid=36481385#top>

LIKELY

SAFE<http://naturaldatabase.therapeuticresearch.com/nd/SearchHelp.aspx?cs=ONDPG & \

s=ND & sh=6 & t=10 & pt=100 & r=100#ri100> ...when used orally as food

(11358<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=11358#11358>,11359<http://naturaldatabase.therapeuticr\

esearch.com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & sh=6 & id=205 & id2=11359#11359>).

Glucomannan powder or flour is often used to enrich noodles in traditional

Japanese foods.

POSSIBLY

SAFE<http://naturaldatabase.therapeuticresearch.com/nd/SearchHelp.aspx?cs=ONDPG & \

s=ND & sh=6 & t=10 & pt=100 & r=101#ri101> ...when used orally in powdered or

encapsulated form. Glucomannan has been safely used in studies lasting up to 4

months

(179<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=ND\

& pt=101 & sh=6 & id=205 & id2=179#179>,180<http://naturaldatabase.therapeuticresearch.\

com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & sh=6 & id=205 & id2=180#180>,180<http://natu\

raldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & sh=6 & id=\

205 & id2=180#180>,182<http://naturaldatabase.therapeuticresearch.com/nd/Search.as\

px?cs=ONDPG & s=ND & pt=101 & sh=6 & id=205 & id2=182#182>,11046<http://naturaldatabase.th\

erapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & sh=6 & id=205 & id2=11046#\

11046>,11357<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ON\

DPG & s=ND & pt=101 & sh=6 & id=205 & id2=11357#11357>).

POSSIBLY

UNSAFE<http://naturaldatabase.therapeuticresearch.com/nd/SearchHelp.aspx?cs=ONDP\

G & s=ND & sh=6 & t=10 & pt=100 & r=102#ri102> ...when used orally in tablet form. There

have been reports of esophageal and gastrointestinal obstruction

(11293<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=11293#11293>). Advise patients to use glucomannan in

powdered or capsule form.

CHILDREN: POSSIBLY

SAFE<http://naturaldatabase.therapeuticresearch.com/nd/SearchHelp.aspx?cs=ONDPG & \

s=ND & sh=6 & t=10 & pt=100 & r=101#ri101> ...when used orally and appropriately in

powdered or encapsulated form. Glucomannan has been safely used in children for

up to 4 months

(179<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=ND\

& pt=101 & sh=6 & id=205 & id2=179#179>,180<http://naturaldatabase.therapeuticresearch.\

com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & sh=6 & id=205 & id2=180#180>). LIKELY

UNSAFE<http://naturaldatabase.therapeuticresearch.com/nd/SearchHelp.aspx?cs=ONDP\

G & s=ND & sh=6 & t=10 & pt=100 & r=103#ri103> ...when used orally in tablet form. There

have been reports of esophageal and gastrointestinal obstruction

(11293<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=11293#11293>).

PREGNANCY AND LACTATION: Insufficient reliable information available; avoid

using.

Effectiveness:

[cid:image001.gif@...]<http://naturaldatabase.therapeuticresearch.\

com/nd/Search.aspx?cs=ONDPG & s=ND & pt=100 & id=205 & fs=ND & searchid=36481385#top>

POSSIBLY

EFFECTIVE<http://naturaldatabase.therapeuticresearch.com/nd/SearchHelp.aspx?cs=O\

NDPG & s=ND & sh=6 & t=10 & pt=100 & r=3#ri3>

Diabetes<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & \

s=ND & Product=Diabetes & pt=11 & sh=6>. Taking glucomannan orally seems to reduce

serum cholesterol and blood glucose levels in patients with type 2 diabetes

(183<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=ND\

& pt=101 & sh=6 & id=205 & id2=183#183>,11357<http://naturaldatabase.therapeuticresearc\

h.com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & sh=6 & id=205 & id2=11357#11357>,11359<htt\

p://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & \

sh=6 & id=205 & id2=11359#11359>). Glucomannan may improve serum total cholesterol,

low-density lipoprotein (LDL) levels, glycemic control, and systolic blood

pressure in patients with type 2 diabetes and hyperlipidemia. Glucomannan also

seems to improve insulin resistance syndrome, a prediabetic metabolic condition.

The positive effect on insulin resistance syndrome appears to occur when

glucomannan is mixed and consumed with carbohydrate foods

(11358<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=11358#11358>).

INSUFFICIENT RELIABLE EVIDENCE to

RATE<http://naturaldatabase.therapeuticresearch.com/nd/SearchHelp.aspx?cs=ONDPG & \

s=ND & sh=6 & t=10 & pt=100 & r=7#ri7>

Constipation<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ON\

DPG & s=ND & Product=Constipation & pt=11 & sh=6>. Preliminary clinical research

suggests that taking glucomannan orally might relieve constipation. As a

nonabsorbable dietary fiber, glucomannan may have a bulk laxative effect

(11294<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=11294#11294>,11295<http://naturaldatabase.therapeuticr\

esearch.com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & sh=6 & id=205 & id2=11295#11295>).

Hypercholesterolemia<http://naturaldatabase.therapeuticresearch.com/nd/Search.as\

px?cs=ONDPG & s=ND & Product=Hypercholesterolemia & pt=11 & sh=6>. Glucomannan 1.2

grams/day in combination with chitosan, 1.2 grams/day for a month seems to

reduce total cholesterol by 7%, low-density lipoprotein (LDL) by 10%, and

increase high-density lipoprotein (HDL) by 4%

(11046<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=11046#11046>).

Obesity<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s\

=ND & Product=Obesity & pt=11 & sh=6>. There is preliminary evidence that taking

glucomannan orally might help reduce weight in obese children and adults

(180<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=ND\

& pt=101 & sh=6 & id=205 & id2=180#180>,181<http://naturaldatabase.therapeuticresearch.\

com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & sh=6 & id=205 & id2=181#181>,182<http://natu\

raldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & sh=6 & id=\

205 & id2=182#182>,183<http://naturaldatabase.therapeuticresearch.com/nd/Search.as\

px?cs=ONDPG & s=ND & pt=101 & sh=6 & id=205 & id2=183#183>). But some research shows no

effect

(179<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=ND\

& pt=101 & sh=6 & id=205 & id2=179#179>).

More evidence is needed to rate glucomannan for these uses.

Mechanism of Action:

[cid:image001.gif@...]<http://naturaldatabase.therapeuticresearch.\

com/nd/Search.aspx?cs=ONDPG & s=ND & pt=100 & id=205 & fs=ND & searchid=36481385#top>

Glucomannan is an unabsorbable polysaccharide composed of glucose and mannose

that is derived from konjac (Amorphophallus konjac) root

(11361<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=11361#11361>). Glucomannan contains insoluble fiber

that may increase water absorption by the stools

(11294<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=11294#11294>,11295<http://naturaldatabase.therapeuticr\

esearch.com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & sh=6 & id=205 & id2=11295#11295>).

Glucomannan seems to reduce serum total cholesterol and low-density lipoprotein

(LDL) cholesterol levels in healthy men

(178<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=ND\

& pt=101 & sh=6 & id=205 & id2=178#178>) and in adults with type 2 diabetes

(11357<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=11357#11357>). Glucomannan appears to improve lipid

profiles by enhancing fecal excretion of cholesterol and bile acid

(11357<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=11357#11357>). Glucomannan may improve glycemic

control in people with type 2 diabetes

(11357<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=11357#11357>,11359<http://naturaldatabase.therapeuticr\

esearch.com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & sh=6 & id=205 & id2=11359#11359>),

possibly by slowing gastric emptying and increasing the viscosity of

gastrointestinal contents

(11361<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=11361#11361>). Glucomannan also seems to improve

systolic blood pressure in people with type 2 diabetes

(11359<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=11359#11359>).

Adverse Reactions:

[cid:image001.gif@...]<http://naturaldatabase.therapeuticresearch.\

com/nd/Search.aspx?cs=ONDPG & s=ND & pt=100 & id=205 & fs=ND & searchid=36481385#top>

Orally, esophageal and gastrointestinal obstructions have been reported when the

tablet form has been used

(11293<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=11293#11293>). Advise patients to use glucomannan in

powdered or capsule form.

Interactions with Herbs & Supplements:

[cid:image001.gif@...]<http://naturaldatabase.therapeuticresearch.\

com/nd/Search.aspx?cs=ONDPG & s=ND & pt=100 & id=205 & fs=ND & searchid=36481385#top>

HERBS AND SUPPLEMENTS WITH HYPOGLYCEMIC POTENTIAL: There is some evidence that

glucomannan might have hypoglycemic effects

(183<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=ND\

& pt=101 & sh=6 & id=205 & id2=183#183>,11357<http://naturaldatabase.therapeuticresearc\

h.com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & sh=6 & id=205 & id2=11357#11357>,11359<htt\

p://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & \

sh=6 & id=205 & id2=11359#11359>). Theoretically, concomitant use with other herbs

and supplements that decrease blood glucose levels might increase the risk of

hypoglycemia. Some of these products include bitter melon, cowhage, ginger,

goat's rue, fenugreek, kudzu, willow bark, and others.

VITAMIN A: Glucomannan may reduce absorption of vitamin A and other fat soluble

vitamins, possibly because it increases excretion of bile acids, which

facilitate the transport and absorption of fat soluble vitamins. It doesn't seem

to affect water-soluble vitamins

(12539<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=12539#12539>).

VITAMIN D: Glucomannan may reduce absorption of vitamin D and other fat soluble

vitamins, possibly because it increases excretion of bile acids, which

facilitate the transport and absorption of fat soluble vitamins. It doesn't seem

to affect water-soluble vitamins

(12539<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=12539#12539>).

VITAMIN E: Glucomannan may reduce absorption of vitamin E and other fat soluble

vitamins, possibly because it increases excretion of bile acids, which

facilitate the transport and absorption of fat soluble vitamins. It doesn't seem

to affect water-soluble vitamins

(12539<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=12539#12539>).

VITAMIN K: Glucomannan may reduce absorption of vitamin K and other fat soluble

vitamins, possibly because it increases excretion of bile acids, which

facilitate the transport and absorption of fat soluble vitamins. It doesn't seem

to affect water-soluble vitamins

(12539<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=12539#12539>).

Interactions with Drugs:

[cid:image001.gif@...]<http://naturaldatabase.therapeuticresearch.\

com/nd/Search.aspx?cs=ONDPG & s=ND & pt=100 & id=205 & fs=ND & searchid=36481385#top>

ANTIDIABETES DRUGS <<interacts with>> GLUCOMANNAN

Interaction

Rating<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=300> = Moderate Be cautious with this combination.

Severity<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & \

s=ND & pt=300> = Moderate *

Occurrence<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDP\

G & s=ND & pt=300> = Probable * Level of

Evidence<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & \

s=ND & pt=301 & level=5> =

B<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=ND & pt\

=301 & level=5>

Glucomannan can reduce blood glucose levels in patients with type 2 diabetes

(11357<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=11357#11357>,11359<http://naturaldatabase.therapeuticr\

esearch.com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & sh=6 & id=205 & id2=11359#11359>)

and might have additive effects on glucose levels when used with antidiabetes

drug therapy. Monitor blood glucose levels closely. Medication dose adjustments

may be necessary. Some antidiabetes drugs include glimepiride (Amaryl),

glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos),

rosiglitazone (Avandia), and others.

ORAL DRUGS <<interacts with>> GLUCOMANNAN

Interaction

Rating<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=300> = Moderate Be cautious with this combination.

Severity<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & \

s=ND & pt=300> = Moderate *

Occurrence<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDP\

G & s=ND & pt=300> = Probable * Level of

Evidence<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & \

s=ND & pt=301 & level=3> =

B<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=ND & pt\

=301 & level=3>

Glucomannan may decrease absorption of drugs taken orally, including

sulfonylurea medications

(11360<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=11360#11360>). Some sulfonylurea drugs include

chlorpropamide (Diabinese), glimepiride (Amaryl), glipizide (Glucotrol),

glyburide (DiaBeta, Glynase PresTab, Micronase), and others. Take oral drugs one

hour before or four hours after glucomannan to avoid decreased or delayed

absorption.

Interactions with Foods:

[cid:image001.gif@...]<http://naturaldatabase.therapeuticresearch.\

com/nd/Search.aspx?cs=ONDPG & s=ND & pt=100 & id=205 & fs=ND & searchid=36481385#top>

None known.

Interactions with Lab Tests:

[cid:image001.gif@...]<http://naturaldatabase.therapeuticresearch.\

com/nd/Search.aspx?cs=ONDPG & s=ND & pt=100 & id=205 & fs=ND & searchid=36481385#top>

CHOLESTEROL: Glucomannan might reduce serum total cholesterol, LDL cholesterol,

and test results in obese adults and adults with type 2 diabetes

(181<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=ND\

& pt=101 & sh=6 & id=205 & id2=181#181>,182<http://naturaldatabase.therapeuticresearch.\

com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & sh=6 & id=205 & id2=182#182>,183<http://natu\

raldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & sh=6 & id=\

205 & id2=183#183>,11357<http://naturaldatabase.therapeuticresearch.com/nd/Search.\

aspx?cs=ONDPG & s=ND & pt=101 & sh=6 & id=205 & id2=11357#11357>,11359<http://naturaldatab\

ase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & sh=6 & id=205 & id2=\

11359#11359>).

GLUCOSE: Glucomannan might reduce blood glucose concentrations and test results

in patients with type 2 diabetes

(11357<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=11357#11357>,11359<http://naturaldatabase.therapeuticr\

esearch.com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & sh=6 & id=205 & id2=11359#11359>).

TRIGLYCERIDES: Glucomannan might reduce serum triglycerides and test results in

obese adults

(181<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=ND\

& pt=101 & sh=6 & id=205 & id2=181#181>,182<http://naturaldatabase.therapeuticresearch.\

com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & sh=6 & id=205 & id2=182#182>).

Interactions with Diseases or Conditions:

[cid:image001.gif@...]<http://naturaldatabase.therapeuticresearch.\

com/nd/Search.aspx?cs=ONDPG & s=ND & pt=100 & id=205 & fs=ND & searchid=36481385#top>

DIABETES: Glucomannan may interfere with blood sugar control

(11357<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=11357#11357>,11359<http://naturaldatabase.therapeuticr\

esearch.com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & sh=6 & id=205 & id2=11359#11359>),

monitor closely.

SURGERY: Glucomannan might affect blood glucose levels. Theoretically,

glucomannan might interfere with blood glucose control during and after surgical

procedures. Tell patients to discontinue glucomannan at least 2 weeks before

elective surgical procedures.

Dosage/Administration:

[cid:image001.gif@...]<http://naturaldatabase.therapeuticresearch.\

com/nd/Search.aspx?cs=ONDPG & s=ND & pt=100 & id=205 & fs=ND & searchid=36481385#top>

ORAL: For adult weight loss, 1 gram three times daily (1 hour before each meal)

(182<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=ND\

& pt=101 & sh=6 & id=205 & id2=182#182>), has been used. For child weight loss, 2 to 3

grams per day has been used

(180<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=ND\

& pt=101 & sh=6 & id=205 & id2=180#180>).

For type 2 diabetes with hyperlipidemia, 3.6 to 10.6 grams per day has been used

(11357<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=11357#11357>,11359<http://naturaldatabase.therapeuticr\

esearch.com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & sh=6 & id=205 & id2=11359#11359>).

For insulin resistance syndrome, 8 to 13 grams per day has been used

(11358<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=11358#11358>).

For hypercholesterolemia, chitosan 1.2 grams/day plus glucomannan 1.2 grams/day

have been used

(11046<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=11046#11046>).

Editor's Comments:

[cid:image001.gif@...]<http://naturaldatabase.therapeuticresearch.\

com/nd/Search.aspx?cs=ONDPG & s=ND & pt=100 & id=205 & fs=ND & searchid=36481385#top>

None.

From: rd-usa [mailto:rd-usa ] On Behalf Of

KristyH

Sent: Wednesday, August 15, 2012 1:53 PM

To: rd-usa

Subject: Glucomannan (Konjac Root)

I had an outpatient come in today asking about this supplement. Does anyone know

anything about it or can you point me to a reputable website to learn more? It

is supposed to promote wt loss, like Lipozene (advertised on TV). thanks.

Kristy Heussner, MS, RD, LD

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[Guest guest]

Here is what I got off the natural medicines database:

Also Known As:

[cid:image001.gif@...]<http://naturaldatabase.therapeuticresearch.\

com/nd/Search.aspx?cs=ONDPG & s=ND & pt=100 & id=205 & fs=ND & searchid=36481385#top>

Glucomanano, Glucomannane, Konjac, Konjac Mannan.

Scientific Name:

[cid:image001.gif@...]<http://naturaldatabase.therapeuticresearch.\

com/nd/Search.aspx?cs=ONDPG & s=ND & pt=100 & id=205 & fs=ND & searchid=36481385#top>

Amorphophallus konjac, synonym Amorphophallus rivieri.

Family: Araceae.

People Use This For:

[cid:image001.gif@...]<http://naturaldatabase.therapeuticresearch.\

com/nd/Search.aspx?cs=ONDPG & s=ND & pt=100 & id=205 & fs=ND & searchid=36481385#top>

Orally, glucomannan is used for constipation, weight loss in adults and

children, type 2 diabetes, blood glucose control, and reducing serum

cholesterol.

In foods, glucomannan is used in food preparation.

Safety:

[cid:image001.gif@...]<http://naturaldatabase.therapeuticresearch.\

com/nd/Search.aspx?cs=ONDPG & s=ND & pt=100 & id=205 & fs=ND & searchid=36481385#top>

LIKELY

SAFE<http://naturaldatabase.therapeuticresearch.com/nd/SearchHelp.aspx?cs=ONDPG & \

s=ND & sh=6 & t=10 & pt=100 & r=100#ri100> ...when used orally as food

(11358<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=11358#11358>,11359<http://naturaldatabase.therapeuticr\

esearch.com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & sh=6 & id=205 & id2=11359#11359>).

Glucomannan powder or flour is often used to enrich noodles in traditional

Japanese foods.

POSSIBLY

SAFE<http://naturaldatabase.therapeuticresearch.com/nd/SearchHelp.aspx?cs=ONDPG & \

s=ND & sh=6 & t=10 & pt=100 & r=101#ri101> ...when used orally in powdered or

encapsulated form. Glucomannan has been safely used in studies lasting up to 4

months

(179<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=ND\

& pt=101 & sh=6 & id=205 & id2=179#179>,180<http://naturaldatabase.therapeuticresearch.\

com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & sh=6 & id=205 & id2=180#180>,180<http://natu\

raldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & sh=6 & id=\

205 & id2=180#180>,182<http://naturaldatabase.therapeuticresearch.com/nd/Search.as\

px?cs=ONDPG & s=ND & pt=101 & sh=6 & id=205 & id2=182#182>,11046<http://naturaldatabase.th\

erapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & sh=6 & id=205 & id2=11046#\

11046>,11357<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ON\

DPG & s=ND & pt=101 & sh=6 & id=205 & id2=11357#11357>).

POSSIBLY

UNSAFE<http://naturaldatabase.therapeuticresearch.com/nd/SearchHelp.aspx?cs=ONDP\

G & s=ND & sh=6 & t=10 & pt=100 & r=102#ri102> ...when used orally in tablet form. There

have been reports of esophageal and gastrointestinal obstruction

(11293<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=11293#11293>). Advise patients to use glucomannan in

powdered or capsule form.

CHILDREN: POSSIBLY

SAFE<http://naturaldatabase.therapeuticresearch.com/nd/SearchHelp.aspx?cs=ONDPG & \

s=ND & sh=6 & t=10 & pt=100 & r=101#ri101> ...when used orally and appropriately in

powdered or encapsulated form. Glucomannan has been safely used in children for

up to 4 months

(179<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=ND\

& pt=101 & sh=6 & id=205 & id2=179#179>,180<http://naturaldatabase.therapeuticresearch.\

com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & sh=6 & id=205 & id2=180#180>). LIKELY

UNSAFE<http://naturaldatabase.therapeuticresearch.com/nd/SearchHelp.aspx?cs=ONDP\

G & s=ND & sh=6 & t=10 & pt=100 & r=103#ri103> ...when used orally in tablet form. There

have been reports of esophageal and gastrointestinal obstruction

(11293<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=11293#11293>).

PREGNANCY AND LACTATION: Insufficient reliable information available; avoid

using.

Effectiveness:

[cid:image001.gif@...]<http://naturaldatabase.therapeuticresearch.\

com/nd/Search.aspx?cs=ONDPG & s=ND & pt=100 & id=205 & fs=ND & searchid=36481385#top>

POSSIBLY

EFFECTIVE<http://naturaldatabase.therapeuticresearch.com/nd/SearchHelp.aspx?cs=O\

NDPG & s=ND & sh=6 & t=10 & pt=100 & r=3#ri3>

Diabetes<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & \

s=ND & Product=Diabetes & pt=11 & sh=6>. Taking glucomannan orally seems to reduce

serum cholesterol and blood glucose levels in patients with type 2 diabetes

(183<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=ND\

& pt=101 & sh=6 & id=205 & id2=183#183>,11357<http://naturaldatabase.therapeuticresearc\

h.com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & sh=6 & id=205 & id2=11357#11357>,11359<htt\

p://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & \

sh=6 & id=205 & id2=11359#11359>). Glucomannan may improve serum total cholesterol,

low-density lipoprotein (LDL) levels, glycemic control, and systolic blood

pressure in patients with type 2 diabetes and hyperlipidemia. Glucomannan also

seems to improve insulin resistance syndrome, a prediabetic metabolic condition.

The positive effect on insulin resistance syndrome appears to occur when

glucomannan is mixed and consumed with carbohydrate foods

(11358<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=11358#11358>).

INSUFFICIENT RELIABLE EVIDENCE to

RATE<http://naturaldatabase.therapeuticresearch.com/nd/SearchHelp.aspx?cs=ONDPG & \

s=ND & sh=6 & t=10 & pt=100 & r=7#ri7>

Constipation<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ON\

DPG & s=ND & Product=Constipation & pt=11 & sh=6>. Preliminary clinical research

suggests that taking glucomannan orally might relieve constipation. As a

nonabsorbable dietary fiber, glucomannan may have a bulk laxative effect

(11294<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=11294#11294>,11295<http://naturaldatabase.therapeuticr\

esearch.com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & sh=6 & id=205 & id2=11295#11295>).

Hypercholesterolemia<http://naturaldatabase.therapeuticresearch.com/nd/Search.as\

px?cs=ONDPG & s=ND & Product=Hypercholesterolemia & pt=11 & sh=6>. Glucomannan 1.2

grams/day in combination with chitosan, 1.2 grams/day for a month seems to

reduce total cholesterol by 7%, low-density lipoprotein (LDL) by 10%, and

increase high-density lipoprotein (HDL) by 4%

(11046<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=11046#11046>).

Obesity<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s\

=ND & Product=Obesity & pt=11 & sh=6>. There is preliminary evidence that taking

glucomannan orally might help reduce weight in obese children and adults

(180<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=ND\

& pt=101 & sh=6 & id=205 & id2=180#180>,181<http://naturaldatabase.therapeuticresearch.\

com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & sh=6 & id=205 & id2=181#181>,182<http://natu\

raldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & sh=6 & id=\

205 & id2=182#182>,183<http://naturaldatabase.therapeuticresearch.com/nd/Search.as\

px?cs=ONDPG & s=ND & pt=101 & sh=6 & id=205 & id2=183#183>). But some research shows no

effect

(179<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=ND\

& pt=101 & sh=6 & id=205 & id2=179#179>).

More evidence is needed to rate glucomannan for these uses.

Mechanism of Action:

[cid:image001.gif@...]<http://naturaldatabase.therapeuticresearch.\

com/nd/Search.aspx?cs=ONDPG & s=ND & pt=100 & id=205 & fs=ND & searchid=36481385#top>

Glucomannan is an unabsorbable polysaccharide composed of glucose and mannose

that is derived from konjac (Amorphophallus konjac) root

(11361<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=11361#11361>). Glucomannan contains insoluble fiber

that may increase water absorption by the stools

(11294<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=11294#11294>,11295<http://naturaldatabase.therapeuticr\

esearch.com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & sh=6 & id=205 & id2=11295#11295>).

Glucomannan seems to reduce serum total cholesterol and low-density lipoprotein

(LDL) cholesterol levels in healthy men

(178<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=ND\

& pt=101 & sh=6 & id=205 & id2=178#178>) and in adults with type 2 diabetes

(11357<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=11357#11357>). Glucomannan appears to improve lipid

profiles by enhancing fecal excretion of cholesterol and bile acid

(11357<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=11357#11357>). Glucomannan may improve glycemic

control in people with type 2 diabetes

(11357<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=11357#11357>,11359<http://naturaldatabase.therapeuticr\

esearch.com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & sh=6 & id=205 & id2=11359#11359>),

possibly by slowing gastric emptying and increasing the viscosity of

gastrointestinal contents

(11361<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=11361#11361>). Glucomannan also seems to improve

systolic blood pressure in people with type 2 diabetes

(11359<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=11359#11359>).

Adverse Reactions:

[cid:image001.gif@...]<http://naturaldatabase.therapeuticresearch.\

com/nd/Search.aspx?cs=ONDPG & s=ND & pt=100 & id=205 & fs=ND & searchid=36481385#top>

Orally, esophageal and gastrointestinal obstructions have been reported when the

tablet form has been used

(11293<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=11293#11293>). Advise patients to use glucomannan in

powdered or capsule form.

Interactions with Herbs & Supplements:

[cid:image001.gif@...]<http://naturaldatabase.therapeuticresearch.\

com/nd/Search.aspx?cs=ONDPG & s=ND & pt=100 & id=205 & fs=ND & searchid=36481385#top>

HERBS AND SUPPLEMENTS WITH HYPOGLYCEMIC POTENTIAL: There is some evidence that

glucomannan might have hypoglycemic effects

(183<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=ND\

& pt=101 & sh=6 & id=205 & id2=183#183>,11357<http://naturaldatabase.therapeuticresearc\

h.com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & sh=6 & id=205 & id2=11357#11357>,11359<htt\

p://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & \

sh=6 & id=205 & id2=11359#11359>). Theoretically, concomitant use with other herbs

and supplements that decrease blood glucose levels might increase the risk of

hypoglycemia. Some of these products include bitter melon, cowhage, ginger,

goat's rue, fenugreek, kudzu, willow bark, and others.

VITAMIN A: Glucomannan may reduce absorption of vitamin A and other fat soluble

vitamins, possibly because it increases excretion of bile acids, which

facilitate the transport and absorption of fat soluble vitamins. It doesn't seem

to affect water-soluble vitamins

(12539<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=12539#12539>).

VITAMIN D: Glucomannan may reduce absorption of vitamin D and other fat soluble

vitamins, possibly because it increases excretion of bile acids, which

facilitate the transport and absorption of fat soluble vitamins. It doesn't seem

to affect water-soluble vitamins

(12539<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=12539#12539>).

VITAMIN E: Glucomannan may reduce absorption of vitamin E and other fat soluble

vitamins, possibly because it increases excretion of bile acids, which

facilitate the transport and absorption of fat soluble vitamins. It doesn't seem

to affect water-soluble vitamins

(12539<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=12539#12539>).

VITAMIN K: Glucomannan may reduce absorption of vitamin K and other fat soluble

vitamins, possibly because it increases excretion of bile acids, which

facilitate the transport and absorption of fat soluble vitamins. It doesn't seem

to affect water-soluble vitamins

(12539<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=12539#12539>).

Interactions with Drugs:

[cid:image001.gif@...]<http://naturaldatabase.therapeuticresearch.\

com/nd/Search.aspx?cs=ONDPG & s=ND & pt=100 & id=205 & fs=ND & searchid=36481385#top>

ANTIDIABETES DRUGS <<interacts with>> GLUCOMANNAN

Interaction

Rating<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=300> = Moderate Be cautious with this combination.

Severity<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & \

s=ND & pt=300> = Moderate *

Occurrence<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDP\

G & s=ND & pt=300> = Probable * Level of

Evidence<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & \

s=ND & pt=301 & level=5> =

B<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=ND & pt\

=301 & level=5>

Glucomannan can reduce blood glucose levels in patients with type 2 diabetes

(11357<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=11357#11357>,11359<http://naturaldatabase.therapeuticr\

esearch.com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & sh=6 & id=205 & id2=11359#11359>)

and might have additive effects on glucose levels when used with antidiabetes

drug therapy. Monitor blood glucose levels closely. Medication dose adjustments

may be necessary. Some antidiabetes drugs include glimepiride (Amaryl),

glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos),

rosiglitazone (Avandia), and others.

ORAL DRUGS <<interacts with>> GLUCOMANNAN

Interaction

Rating<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=300> = Moderate Be cautious with this combination.

Severity<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & \

s=ND & pt=300> = Moderate *

Occurrence<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDP\

G & s=ND & pt=300> = Probable * Level of

Evidence<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & \

s=ND & pt=301 & level=3> =

B<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=ND & pt\

=301 & level=3>

Glucomannan may decrease absorption of drugs taken orally, including

sulfonylurea medications

(11360<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=11360#11360>). Some sulfonylurea drugs include

chlorpropamide (Diabinese), glimepiride (Amaryl), glipizide (Glucotrol),

glyburide (DiaBeta, Glynase PresTab, Micronase), and others. Take oral drugs one

hour before or four hours after glucomannan to avoid decreased or delayed

absorption.

Interactions with Foods:

[cid:image001.gif@...]<http://naturaldatabase.therapeuticresearch.\

com/nd/Search.aspx?cs=ONDPG & s=ND & pt=100 & id=205 & fs=ND & searchid=36481385#top>

None known.

Interactions with Lab Tests:

[cid:image001.gif@...]<http://naturaldatabase.therapeuticresearch.\

com/nd/Search.aspx?cs=ONDPG & s=ND & pt=100 & id=205 & fs=ND & searchid=36481385#top>

CHOLESTEROL: Glucomannan might reduce serum total cholesterol, LDL cholesterol,

and test results in obese adults and adults with type 2 diabetes

(181<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=ND\

& pt=101 & sh=6 & id=205 & id2=181#181>,182<http://naturaldatabase.therapeuticresearch.\

com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & sh=6 & id=205 & id2=182#182>,183<http://natu\

raldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & sh=6 & id=\

205 & id2=183#183>,11357<http://naturaldatabase.therapeuticresearch.com/nd/Search.\

aspx?cs=ONDPG & s=ND & pt=101 & sh=6 & id=205 & id2=11357#11357>,11359<http://naturaldatab\

ase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & sh=6 & id=205 & id2=\

11359#11359>).

GLUCOSE: Glucomannan might reduce blood glucose concentrations and test results

in patients with type 2 diabetes

(11357<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=11357#11357>,11359<http://naturaldatabase.therapeuticr\

esearch.com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & sh=6 & id=205 & id2=11359#11359>).

TRIGLYCERIDES: Glucomannan might reduce serum triglycerides and test results in

obese adults

(181<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=ND\

& pt=101 & sh=6 & id=205 & id2=181#181>,182<http://naturaldatabase.therapeuticresearch.\

com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & sh=6 & id=205 & id2=182#182>).

Interactions with Diseases or Conditions:

[cid:image001.gif@...]<http://naturaldatabase.therapeuticresearch.\

com/nd/Search.aspx?cs=ONDPG & s=ND & pt=100 & id=205 & fs=ND & searchid=36481385#top>

DIABETES: Glucomannan may interfere with blood sugar control

(11357<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=11357#11357>,11359<http://naturaldatabase.therapeuticr\

esearch.com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & sh=6 & id=205 & id2=11359#11359>),

monitor closely.

SURGERY: Glucomannan might affect blood glucose levels. Theoretically,

glucomannan might interfere with blood glucose control during and after surgical

procedures. Tell patients to discontinue glucomannan at least 2 weeks before

elective surgical procedures.

Dosage/Administration:

[cid:image001.gif@...]<http://naturaldatabase.therapeuticresearch.\

com/nd/Search.aspx?cs=ONDPG & s=ND & pt=100 & id=205 & fs=ND & searchid=36481385#top>

ORAL: For adult weight loss, 1 gram three times daily (1 hour before each meal)

(182<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=ND\

& pt=101 & sh=6 & id=205 & id2=182#182>), has been used. For child weight loss, 2 to 3

grams per day has been used

(180<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=ND\

& pt=101 & sh=6 & id=205 & id2=180#180>).

For type 2 diabetes with hyperlipidemia, 3.6 to 10.6 grams per day has been used

(11357<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=11357#11357>,11359<http://naturaldatabase.therapeuticr\

esearch.com/nd/Search.aspx?cs=ONDPG & s=ND & pt=101 & sh=6 & id=205 & id2=11359#11359>).

For insulin resistance syndrome, 8 to 13 grams per day has been used

(11358<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=11358#11358>).

For hypercholesterolemia, chitosan 1.2 grams/day plus glucomannan 1.2 grams/day

have been used

(11046<http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=ONDPG & s=\

ND & pt=101 & sh=6 & id=205 & id2=11046#11046>).

Editor's Comments:

[cid:image001.gif@...]<http://naturaldatabase.therapeuticresearch.\

com/nd/Search.aspx?cs=ONDPG & s=ND & pt=100 & id=205 & fs=ND & searchid=36481385#top>

None.

From: rd-usa [mailto:rd-usa ] On Behalf Of

KristyH

Sent: Wednesday, August 15, 2012 1:53 PM

To: rd-usa

Subject: Glucomannan (Konjac Root)

I had an outpatient come in today asking about this supplement. Does anyone know

anything about it or can you point me to a reputable website to learn more? It

is supposed to promote wt loss, like Lipozene (advertised on TV). thanks.

Kristy Heussner, MS, RD, LD

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