Re: RESEARCH - Vitamin K in hand osteoarthritis: results from a randomized clinical trial

[Guest guest]

, since my hands are literally killing me and I got no sleep last nite, I

have read this twice and am still confused. Would you mind too much telling me

what you think this says in language someone confused might understand? Thanks

a

[ ] RESEARCH - Vitamin K in hand osteoarthritis: results

from a randomized clinical trial

Ann Rheum Dis. Published Online First: 14 July 2008.

doi:10.1136/ard.2008.094771

----------------------------------------------------------

Concise Report

Vitamin K in hand osteoarthritis: results from a Randomized Clinical Trial

T Neogi 1*, D T Felson 2, R Sarno 3 and S L Booth 4

1 Boston University School of Medicine, United States

2 Boston University, United States

3 Tufts Medical Center, United States

4 Tufts University, United States

Abstract

Objectives: Vitamin K (VK) has bone and cartilage effects, and

previously shown to be associated with radiographic OA. We evaluated

VK's effect on hand osteoarthritis (OA) in a randomized controlled

trial (RCT).

Methods: The was an ancillary study to a RCT assessing the effects of

phylloquinone supplementation (VK arm) versus placebo on bone loss and

vascular calcification among older adults regardless of their VK

status. At the final 3-year study visit, we assessed the effects of VK

versus placebo on hand x-ray features of OA using logistic regression

and intention to treat, and also restricted analysis to the subgroup

that had insufficient VK concentrations at baseline.

Results: This ancillary study had 378 participants (193 in VK arm, 185

in placebo arm). There were no effects of randomization to VK for

radiographic OA outcomes. Those with insufficient VK at baseline who

attained sufficient concentrations at follow-up had trends towards 47%

less joint-space narrowing (p=0.02).

Conclusions: There was no overall effect of VK on radiographic hand

OA. Subjects that were insufficient in VK at baseline who attained

sufficient concentrations at follow-up may have had a benefit in

joint-space narrowing. A clinical trial in those who are VK

insufficient may be warranted.

http://ard.bmj.com/cgi/content/abstract/ard.2008.094771v1?papetoc

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Not an MD

[Guest guest]

a,

This study was trying to determine whether vitamin K supplementation

had any effect on the changes caused by osteoarthritis (OA, not RA).

What the researchers found was that, for those who had lower than

normal vitamin K levels to begin with, there was less joint space

narrowing once their vitamin K levels were normalized.

" Joint Space Narrowing - What's the Significance? " :

http://osteoarthritis.about.com/od/osteoarthritissymptoms/f/joint_space.htm

Not an MD

On Tue, Jul 15, 2008 at 8:22 AM, patandpaula <patandpaula@...> wrote:

> , since my hands are literally killing me and I got no sleep last nite,

> I have read this twice and am still confused. Would you mind too much

> telling me what you think this says in language someone confused might

> understand? Thanks a

[Guest guest]

Thank you

Re: [ ] RESEARCH - Vitamin K in hand osteoarthritis: results

from a randomized clinical trial

a,

This study was trying to determine whether vitamin K supplementation

had any effect on the changes caused by osteoarthritis (OA, not RA).

What the researchers found was that, for those who had lower than

normal vitamin K levels to begin with, there was less joint space

narrowing once their vitamin K levels were normalized.

" Joint Space Narrowing - What's the Significance? " :

http://osteoarthritis.about.com/od/osteoarthritissymptoms/f/joint_space.htm

Not an MD

On Tue, Jul 15, 2008 at 8:22 AM, patandpaula <patandpaula@...>

wrote:

> , since my hands are literally killing me and I got no sleep last nite,

> I have read this twice and am still confused. Would you mind too much

> telling me what you think this says in language someone confused might

> understand? Thanks a