RESEARCH - Vitamin K in hand osteoarthritis: results from a randomized clinical trial

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Ann Rheum Dis. Published Online First: 14 July 2008. doi:10.1136/ard.2008.094771

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Concise Report

Vitamin K in hand osteoarthritis: results from a Randomized Clinical Trial

T Neogi 1*, D T Felson 2, R Sarno 3 and S L Booth 4

1 Boston University School of Medicine, United States

2 Boston University, United States

3 Tufts Medical Center, United States

4 Tufts University, United States

Abstract

Objectives: Vitamin K (VK) has bone and cartilage effects, and

previously shown to be associated with radiographic OA. We evaluated

VK's effect on hand osteoarthritis (OA) in a randomized controlled

trial (RCT).

Methods: The was an ancillary study to a RCT assessing the effects of

phylloquinone supplementation (VK arm) versus placebo on bone loss and

vascular calcification among older adults regardless of their VK

status. At the final 3-year study visit, we assessed the effects of VK

versus placebo on hand x-ray features of OA using logistic regression

and intention to treat, and also restricted analysis to the subgroup

that had insufficient VK concentrations at baseline.

Results: This ancillary study had 378 participants (193 in VK arm, 185

in placebo arm). There were no effects of randomization to VK for

radiographic OA outcomes. Those with insufficient VK at baseline who

attained sufficient concentrations at follow-up had trends towards 47%

less joint-space narrowing (p=0.02).

Conclusions: There was no overall effect of VK on radiographic hand

OA. Subjects that were insufficient in VK at baseline who attained

sufficient concentrations at follow-up may have had a benefit in

joint-space narrowing. A clinical trial in those who are VK

insufficient may be warranted.

http://ard.bmj.com/cgi/content/abstract/ard.2008.094771v1?papetoc

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