Re: Chris in the UK Methotrexate

[Guest guest]

 Hello Leonie and ,

 

Sorry if I missed that post. I am not born organised!

Fortunately and as ever has come up with the info. I will try and post

again about it soon if I get the chance.

Generally the message is that whatever amount of methotrexate is absorbed 

(complete with injection of course) variable with oral will be metabolised by

the liver and yes, may affect the liver adversely in certain patients (one of

the reasons for monitoring  regularly with lab work)

As to advantage of injections over tablets, well this is a tricky area.

My understanding of research and trials is that for some tablets are fine but

for a significant group injections are better tolerated .Absorption of tabs

therefore dose can vary, especially in people with IBS say.

Here in the UK there are great tactical  NHS obstacles to giving MTX

by injection outside the inpatient setting, and my friend has been told they

can't be given her, although she has awful gut problems.It varies from region to

region. I really find this hard to understand.

I know you are in Australia, so it would be different there.

Best wishes

Chris

UK

From: mumpup2000 <leoniecent@...>

Subject: [ ] in the UK

Date: Tuesday, 7 October, 2008, 1:28 AM

Hi

I noticed in an earlier post that monique asked you about methotrexate

injections and whether they affect the liver like the pills do. She has

problems with her liver detox pathways and can't take meds without

getting sick. Do you happen to know the answer to this ? Also, i have

an ulcer so would mtx be best in injection for me ? I don't want to

upset my stomach. I'm not sure why my rheumy didn't suggest injections.

all the best,

Leonie

[Guest guest]

That's ok Chris. I know how easy it is to miss posts... i do it all

the time. I reckon you'd be pretty good to see them all.

Thanks for the info on mtx. If i'm going to ask for mtx injections,

i need to have a good case for it, so you can see why i'm asking.

thanks again,

Leonie

>

> From: mumpup2000 <leoniecent@...>

> Subject: [ ] in the UK

>

> Date: Tuesday, 7 October, 2008, 1:28 AM

>

>

>

>

>

>

> Hi

> I noticed in an earlier post that monique asked you about

methotrexate

> injections and whether they affect the liver like the pills do. She

has

> problems with her liver detox pathways and can't take meds without

> getting sick. Do you happen to know the answer to this ? Also, i

have

> an ulcer so would mtx be best in injection for me ? I don't want to

> upset my stomach. I'm not sure why my rheumy didn't suggest

injections.

> all the best,

> Leonie

>