EDITORIAL - An important step towards completing the RA cycle

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Arthritis Research & Therapy 2008, 10:117doi:10.1186/ar2504

See related research by et al.,

http://arthritis-research.com/content/10/4/R94

Published: 19 September 2008

Editorial

An important step towards completing the rheumatoid arthritis cycle

Walther J van Venrooij and Ger JM Pruijn

Department of Biomolecular Chemistry, Radboud University Nijmegen,

NL-6500 HB Nijmegen, The Netherlands

Abstract

In the previous issue of Arthritis Research & Therapy data are

presented showing that circulating immune complexes containing

citrullinated fibrin(ogen) are present in anti-citrullinated protein

antibody-positive rheumatoid arthritis patients, and that such immune

complexes co-localize with complement factor C3 in the rheumatoid

synovium. These results corroborate the idea that citrullination is

intimately involved in the pathophysiology of rheumatoid arthritis and

complete our model (the rheumatoid arthritis cycle) for the

development and chronic nature of this disease.

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Read the full article here:

http://arthritis-research.com/content/10/5/117

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