RESEARCH - The synovitis of non-inflammatory orthopaedic arthropathies

[Guest guest]

Ann Rheum Dis. 2008 Aug;67(8):1184-7. Epub 2008 Jan 18.

The synovitis of " non-inflammatory " orthopaedic arthropathies: a

quantitative histological and immunohistochemical analysis.

Pessler F, Dai L, -Torne C, Gomez-Vaquero C, Paessler ME, Zheng

DH, Einhorn E, Range U, Scanzello C, Schumacher HR.

The Children's Hospital of Philadelphia, Division of Rheumatology,

Philadelphia, USA.

OBJECTIVE: To quantify inflammatory changes in synovial membranes from

orthopaedic " non-inflammatory " arthropathies (Orth. A). METHODS:

Synovial membranes from patients with femur fracture, avascular

necrosis of the femur, plica syndrome, and meniscus and/or ligament

injury (n = 23); rheumatoid arthritis (n = 28); osteoarthritis (OA; n

= 25); and from normal controls (n = 10) were assessed by light

microscopy, a histological synovitis score, immunostaining for CD3,

CD20, CD38, CD68, Ki-67 and von Willebrand factor, and with an

immunohistochemical inflammation score. RESULTS: Orth. A histology

varied between normal and markedly inflamed. Predominant abnormalities

were mild lining hyperplasia, scattered inflammatory cells and small

perivascular infiltrates. The synovitis score classified Orth. A as

" mild synovitis " . Inflammatory cells occurred frequently: CD68+ cells

in 100% of Orth. A specimens; CD3+, 91%; CD38+, 70%; and CD20+, 39%.

Orth. A had 36% greater lining thickness (p = 0.04), 40% higher

vascular density (p = 0.009) and 51.3-fold higher CD38+ cell density

(p = 0.02) than normal controls; and 60% fewer subintimal Ki-67+ cells

(p = 0.003), 42% fewer CD68+ lining cells (p<0.01) and 40% fewer

subintimal CD68+ cells (p<0.01) than OA. The immunohistochemical

inflammation score was 2.2-fold higher in Orth. A than in controls (p

= 0.048) and similar to OA, with three Orth. A specimens showing

marked inflammation.

CONCLUSIONS: Synovial membranes from " non-inflammatory " arthropathies

featured neovascularisation and inflammation intermediate between

normal and OA synovium. These results expand previous findings that

mechanical joint injury may lead to a mild-to-moderate synovitis.

PMID: 18203762

http://www.ncbi.nlm.nih.gov/pubmed/18203762

--

Not an MD

[Guest guest]

and Group;

I have no idea what that means. lol

Clora

but thanks anyway.

> Ann Rheum Dis. 2008 Aug;67(8):1184-7. Epub 2008 Jan 18.

>

>

> The synovitis of " non-inflammatory " orthopaedic arthropathies: a

> quantitative histological and immunohistochemical analysis.

>

>

> Pessler F, Dai L, -Torne C, Gomez-Vaquero C, Paessler ME, Zheng

> DH, Einhorn E, Range U, Scanzello C, Schumacher HR.

> The Children's Hospital of Philadelphia, Division of Rheumatology,

> Philadelphia, USA.

>

>

> OBJECTIVE: To quantify inflammatory changes in synovial membranes

from

> orthopaedic " non-inflammatory " arthropathies (Orth. A). METHODS:

> Synovial membranes from patients with femur fracture, avascular

> necrosis of the femur, plica syndrome, and meniscus and/or ligament

> injury (n = 23); rheumatoid arthritis (n = 28); osteoarthritis

(OA; n

> = 25); and from normal controls (n = 10) were assessed by light

> microscopy, a histological synovitis score, immunostaining for CD3,

> CD20, CD38, CD68, Ki-67 and von Willebrand factor, and with an

> immunohistochemical inflammation score. RESULTS: Orth. A histology

> varied between normal and markedly inflamed. Predominant

abnormalities

> were mild lining hyperplasia, scattered inflammatory cells and

small

> perivascular infiltrates. The synovitis score classified Orth. A as

> " mild synovitis " . Inflammatory cells occurred frequently: CD68+

cells

> in 100% of Orth. A specimens; CD3+, 91%; CD38+, 70%; and CD20+,

39%.

> Orth. A had 36% greater lining thickness (p = 0.04), 40% higher

> vascular density (p = 0.009) and 51.3-fold higher CD38+ cell

density

> (p = 0.02) than normal controls; and 60% fewer subintimal Ki-67+

cells

> (p = 0.003), 42% fewer CD68+ lining cells (p<0.01) and 40% fewer

> subintimal CD68+ cells (p<0.01) than OA. The immunohistochemical

> inflammation score was 2.2-fold higher in Orth. A than in controls

(p

> = 0.048) and similar to OA, with three Orth. A specimens showing

> marked inflammation.

>

> CONCLUSIONS: Synovial membranes from " non-inflammatory "

arthropathies

> featured neovascularisation and inflammation intermediate between

> normal and OA synovium. These results expand previous findings that

> mechanical joint injury may lead to a mild-to-moderate synovitis.

>

>

> PMID: 18203762

>

> http://www.ncbi.nlm.nih.gov/pubmed/18203762

>

>

>

> --

>

> Not an MD

>