Re: RESEARCH - Cigarette smoke condensate upregulates the gene and protein expression of proinflammatory cytokines in human fibroblast-like synoviocyte line

[Guest guest]

Thank you, . I knew if anyone would find the article linking

smoking and RA, you would...........Doreen

>

> J Interferon Cytokine Res. 2008 Aug;28(8):509-21.

>

>

> Cigarette smoke condensate upregulates the gene and protein

> expressionof proinflammatory cytokines in human fibroblast-like

> synoviocyte line.

>

>

> Shizu M, Itoh Y, Sunahara R, Chujo S, Hayashi H, Ide Y, Takii T,

> Koshiko M, Chung SW, Hayakawa K, Miyazawa K, Hirose K, Onozaki K.

> Department of Molecular Health Sciences, Graduate School of

> Pharmaceutical Sciences, Nagoya City University, Mizuho, Nagoya,

> Japan.

>

>

> Rheumatoid arthritis (RA) is characterized by proliferation of

> synoviocytes that produce proinflammatory cytokines, which are

> implicated in the pathogenesis of RA. When human fibroblast-like

> synoviocytes line MH7A was treated with cigarette smoke condensate

> (CSC), either mainstream or sidestream, expression levels of

> interleukin (IL)-1alpha, IL-1beta, IL-6, IL-8, and CYP1A1 mRNA were

> upregulated in both time- and dose-dependent manners. The

> upregulatory effects of CSC on these cytokines were not

> significantly inhibited by alpha-naphthoflavone, an aryl

> hydrocarbon receptor (AhR) antagonist, suggesting that the effects

> of CSC were independent of AhR. Cycloheximide treatment indicated

> that the augmenting effect of CSC on IL-1alpha, IL-1beta and IL-8,

> but not IL-6 and CYP1A1, mRNA expression requires de novo protein

> synthesis. CSC also induced cytokines at protein levels and further

> augmented the effects of tumor necrosis factor alpha on induction

> of these cytokines at both mRNA and protein levels.

>

> These results support the epidemiological studies indicating a

> strong association between heavy cigarette smoking and pathogenesis

> of RA.

>

> PMID: 18729741

>

> http://www.ncbi.nlm.nih.gov/pubmed/18729741

>

>

> Not an MD

>

[Guest guest]

Hi, Stan.

No, it's not OK to smoke if you have RA.

The researchers were attempting to simulate the effects of smoking on

the immune system. They found that the production of proinflammatory

cytokines increased. The proinflammatory cytokines we talk about most

at RA-Support are tumor necrosis factor (TNF) and interleukin (IL).

Enbrel, Humira, and Remicade block TNF, and Kineret interferes with

IL.

The conclusion of the abstract is: " These results support the

epidemiological studies indicating a strong association between heavy

cigarette smoking and pathogenesis of RA. "

" Pathogenesis " is how a disease develops. This study adds to the great

amount of evidence which already exists which demonstrates that, in

those genetically susceptible, smoking can lead to the onset of

rheumatoid arthritis.

Not an MD

On Fri, Oct 31, 2008 at 11:30 AM, <stanpfister@...> wrote:

> I " think " it means its alright to smoke even if you have RA?

>

> Stan

> Not an MD

[Guest guest]

I think everyone knows smoking is also bad for the lungs. Just my opinion

 

Clora

 

*********************************************

 

> I " think " it means its alright to smoke even if you have RA?

>

> Stan

> Not an MD

[Guest guest]

Hi, Clora.

Smoking affects more than one's lungs.

For example, people with RA are at a higher risk of cardiovascular

events than the normal population. If people with RA smoke, they are

adding to that risk.

Not an MD

On Sat, Nov 1, 2008 at 12:38 PM, Clora <clora4jesus@...> wrote:

> I think everyone knows smoking is also bad for the lungs. Just my opinion

>

> Clora

[Guest guest]

Group and 

 

It figures,  haaaaaaaa.  Smoking is bad for everyplace in the body it seems. 

The government should add that to their anti-smoking  adds. Maybe kids will

think twice about starting.

 

hugs

Clora

 

******************************************

 

> I think everyone knows smoking is also bad for the lungs. Just my opinion

>

> Clora

[Guest guest]

Group;

 

OK got my pain meds in the mail.  Their called  

BUTALBITAL/APAP/CAFFEINE*TB

 

This is how it says to take it

Take 2tablets at onset of headache

then take 1 tablet every 6 hours.

 

Anyone know any other names these meds go by.  I myself never heard of this. 

 

gentle hugs

Clora

 

**************************************************************

 

[

[Guest guest]

Group;

 

I got a question.  Do I take 2 pills and than 1 pill? 

 

or

 

Do I take 2 pills waits 6 hours and take one pill?

 

The directions are under the line here.

***************************************

 

Group;

 

OK got my pain meds in the mail.  Their called  

BUTALBITAL/APAP/ CAFFEINE* TB

 

This is how it says to take it

Take 2tablets at onset of headache

then take 1 tablet every 6 hours.

 

Anyone know any other names these meds go by.  I myself never heard of this. 

 

gentle hugs

Clora

 

************ ********* ********* ********* ********* ********* *****

 

[

[Guest guest]

Clora, I have that med for migraines. I take one if I have a really bad

migraine, which I don't have many of any more, thank goodness.

The trouble with a lot of migraine medications is the caffeine they

contain. It's hard to get to sleep when you've just taken a pill with

so much caffeine.

I hope they work for you.

Sue

On Saturday, November 1, 2008, at 01:41 PM, Clora wrote:

>

> OK got my pain meds in the mail.  Their called  

> BUTALBITAL/APAP/CAFFEINE*TB

>  

> This is how it says to take it

> Take 2tablets at onset of headache

> then take 1 tablet every 6 hours.

>  

> Anyone know any other names these meds go by.  I myself never heard of

> this. 

[Guest guest]

Hi Clora,

Glad you finally received your pain meds. Hope they help you. Tried

looking that up in my nursing drug book but it didn't say what the

name of them is.

soft hugs,

Debbie L

>

> Group;

>  

> OK got my pain meds in the mail.  Their called  

> BUTALBITAL/APAP/CAFFEINE*TB

>  

> This is how it says to take it

> Take 2tablets at onset of headache

> then take 1 tablet every 6 hours.

>  

> Anyone know any other names these meds go by.  I myself never heard

of this. 

>  

> gentle hugs

> Clora

>  

> **************************************************************

>

>

>

>  

>

>

> [

>

>

>

>

>

[Guest guest]

Debbie and group;

 

Awe thanks ,  Yes they helped.  Thank God

 

hugs

Clora

 

**********************************************

 

From: deebs87 <dlohf@...>

Subject: [ ] Re: RESEARCH - Cigarette smoke condensate upregulates the

gene and protein expression of proinflammatory cytokines in human

fibroblast-like synoviocyte line

Date: Saturday, November 1, 2008, 8:28 PM

Hi Clora,

Glad you finally received your pain meds. Hope they help you. Tried

looking that up in my nursing drug book but it didn't say what the

name of them is.

soft hugs,

Debbie L

>

> Group;

>  

> OK got my pain meds in the mail.  Their called  

> BUTALBITAL/APAP/ CAFFEINE* TB

>  

> This is how it says to take it

> Take 2tablets at onset of headache

> then take 1 tablet every 6 hours.

>  

> Anyone know any other names these meds go by.  I myself never heard

of this. 

>  

> gentle hugs

> Clora

>  

> ************ ********* ********* ********* ********* ********* *****

>

>

>

>  

>

>

> [

>

>

>

>

>