Guest guest Posted December 16, 2000 Report Share Posted December 16, 2000 Whoooooooooo!!!!! Ultra-Fab Barbara!!! Thanks for info!!-Lori:) Quinidine abstract > Dear Crew, > Here is the abstract...trying to get the actual article. Also have forwarded > to several doctors for their thoughts which, of course, I will share with you. > > 1: Neurobiol Dis 2000 Aug;7(4):483-91 > > Enhanced proliferation and potassium conductance of Schwann cells isolated > from > NF2 schwannomas can be reduced by quinidine. > > Rosenbaum C, Kamleiter M, Grafe P, Kluwe L, Mautner V, Muller HW, Hanemann CO > > Department of Neurology, Heinrich-Heine University, Duesseldorf, Germany. > > Neurofibromatosis type 2 (NF2) is an autosomal dominant disease that is > characterized mainly by schwannomas, as well as menigiomas and gliomas. The > NF2 > gene product merlin/schwannomin acts as a tumor suppressor. Schwann cells > derived from NF2 schwannomas showed an enhanced proliferation rate, and > electrophysological studies revealed larger K(+) outward currents as compared > with controls. Schwann cells isolated from schwannomas of NF2 patients or > multiorgan donors were treated with different concentrations of the K(+) > current > blockers quinidine, tetraethylammonium chloride, and 4-aminopyridine and K(+) > outward currents and proliferation rates of these cells were compared. K(+) > outward currents of both cell types can be blocked by quinidine. Importantly, > treatment with quinidine reduces proliferation of NF2 Schwann cells in a > concentration dependent manner but did not reduce proliferation of normal > Schwann cells. Therefore, the use of quinidine or quinidine-like components > would possibly provide a novel adjuvant therapeutic option for NF2 patients to > slow down or freeze growth of schwannomas. Copyright 2000 Academic Press. > > PMID: 10964617, UI: 20423126 > > Barbara lin > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 16, 2000 Report Share Posted December 16, 2000 Whoooooooooo!!!!! Ultra-Fab Barbara!!! Thanks for info!!-Lori:) Quinidine abstract > Dear Crew, > Here is the abstract...trying to get the actual article. Also have forwarded > to several doctors for their thoughts which, of course, I will share with you. > > 1: Neurobiol Dis 2000 Aug;7(4):483-91 > > Enhanced proliferation and potassium conductance of Schwann cells isolated > from > NF2 schwannomas can be reduced by quinidine. > > Rosenbaum C, Kamleiter M, Grafe P, Kluwe L, Mautner V, Muller HW, Hanemann CO > > Department of Neurology, Heinrich-Heine University, Duesseldorf, Germany. > > Neurofibromatosis type 2 (NF2) is an autosomal dominant disease that is > characterized mainly by schwannomas, as well as menigiomas and gliomas. The > NF2 > gene product merlin/schwannomin acts as a tumor suppressor. Schwann cells > derived from NF2 schwannomas showed an enhanced proliferation rate, and > electrophysological studies revealed larger K(+) outward currents as compared > with controls. Schwann cells isolated from schwannomas of NF2 patients or > multiorgan donors were treated with different concentrations of the K(+) > current > blockers quinidine, tetraethylammonium chloride, and 4-aminopyridine and K(+) > outward currents and proliferation rates of these cells were compared. K(+) > outward currents of both cell types can be blocked by quinidine. Importantly, > treatment with quinidine reduces proliferation of NF2 Schwann cells in a > concentration dependent manner but did not reduce proliferation of normal > Schwann cells. Therefore, the use of quinidine or quinidine-like components > would possibly provide a novel adjuvant therapeutic option for NF2 patients to > slow down or freeze growth of schwannomas. Copyright 2000 Academic Press. > > PMID: 10964617, UI: 20423126 > > Barbara lin > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 16, 2000 Report Share Posted December 16, 2000 Whoooooooooo!!!!! Ultra-Fab Barbara!!! Thanks for info!!-Lori:) Quinidine abstract > Dear Crew, > Here is the abstract...trying to get the actual article. Also have forwarded > to several doctors for their thoughts which, of course, I will share with you. > > 1: Neurobiol Dis 2000 Aug;7(4):483-91 > > Enhanced proliferation and potassium conductance of Schwann cells isolated > from > NF2 schwannomas can be reduced by quinidine. > > Rosenbaum C, Kamleiter M, Grafe P, Kluwe L, Mautner V, Muller HW, Hanemann CO > > Department of Neurology, Heinrich-Heine University, Duesseldorf, Germany. > > Neurofibromatosis type 2 (NF2) is an autosomal dominant disease that is > characterized mainly by schwannomas, as well as menigiomas and gliomas. The > NF2 > gene product merlin/schwannomin acts as a tumor suppressor. Schwann cells > derived from NF2 schwannomas showed an enhanced proliferation rate, and > electrophysological studies revealed larger K(+) outward currents as compared > with controls. Schwann cells isolated from schwannomas of NF2 patients or > multiorgan donors were treated with different concentrations of the K(+) > current > blockers quinidine, tetraethylammonium chloride, and 4-aminopyridine and K(+) > outward currents and proliferation rates of these cells were compared. K(+) > outward currents of both cell types can be blocked by quinidine. Importantly, > treatment with quinidine reduces proliferation of NF2 Schwann cells in a > concentration dependent manner but did not reduce proliferation of normal > Schwann cells. Therefore, the use of quinidine or quinidine-like components > would possibly provide a novel adjuvant therapeutic option for NF2 patients to > slow down or freeze growth of schwannomas. Copyright 2000 Academic Press. > > PMID: 10964617, UI: 20423126 > > Barbara lin > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 17, 2000 Report Share Posted December 17, 2000 Barbara, Thanks so much for this post. I have the ear of Anne's oncologist but I just did not know how to refer him. I will forward this immediately to the neurologist so that she can send to the oncologist. You are probably aware that Anne is on Thalidomide. We just did blood work from the first month low dosage so we'll see if it has effected her white blood cells. This is scary but looking at these tumors growing and popping out everywhere, we are compelled to try whatever just may work. You know what I mean? Thanks again. We'll look forward to further updates. Vicki Quote Link to comment Share on other sites More sharing options...
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