Vit A an antagonist for D?

[Guest guest]

Hi All this was posted on newWAHB (baby) forums. I was hoping others

would weigh in with what they know.

It is an email from Cannell - Vitamin D Counsel

I will post the pertinent part of the email correspondance below. He

is talking with a mother of an Autistic Child and how D can help with

symptoms. Let me know if you want me to post he whole email

conversation or if this is enough info in understanding his position.

*******

I'm glad the improvements are continuing. I see Dr. Yasko recommends

10,000 IU of vitamin A/day as well as cod liver oil. I strongly

disagree. Make sure your son is taking neither vitamin A nor cod

liver oil. Rather, make sure he eats colored fruits and vegetables

as well as fortified oatmeal. Vitamin A interferes with vitamin D's

function, especially at the doses Dr. Yasko recommends.

Vitamin A antagonizes the action of vitamin D. In humans, even the

vitamin A in a single serving of liver impairs vitamin D's rapid

intestinal calcium response. Furthermore, the consumption of

preformed retinols, even in amounts consumed by many Americans in

both multivitamins and cod liver oil appears to be causing low-grade,

but widespread, bone toxicity, perhaps through its antagonism of

vitamin D. In a recent dietary intake study, Kyungwon et al found

high retinol intake completely thwarted vitamin D's otherwise

protective effect on distal colorectal adenoma and they found a clear

relationship between vitamin D and vitamin A intakes as the women in

the highest quintile of vitamin D intake also ingested almost 10,000

IU of retinols/day. As early as 1933, Hess et al warned about

vitamin A consumption, concluding, " as to a requirement of thousands

of units of vitamin A daily, the unquestionable answer is that this

constitutes therapeutic absurdity, which, happily, will prove to be

only a passing fad. "

Rohde CM, Deluca HF. All-trans retinoic acid antagonizes the action

of calciferol and its active metabolite, 1,25-

dihydroxycholecalciferol, in rats. J Nutr. 2005;135(7):1647-1652.

Johansson S, Melhus H. Vitamin A antagonizes calcium response to

vitamin D in man. J Bone Miner Res. 2001;16(10):1899-1905.

Penniston KL, Tanumihardjo SA. The acute and chronic toxic effects of

vitamin A. Am J Clin Nutr. 2006;83(2):191-201.

Oh K, Willett WC, Wu K, Fuchs CS, Giovannucci EL. Calcium and vitamin

D intakes in relation to risk of distal colorectal adenoma in women.

Am J Epidemiol. 2007;165(10):1178-1186.

Hess AF, JM, Barenberg LH. Does our dietary require vitamin A

supplement? JAMA. 1933;101:657-663.

Unfortunately, Hess's prophecy of a passing fad proved premature and

many Americans continue to consume " absurd " and dangerous quantities

of vitamin A. For example, multivitamins, until recently, had small

amounts of vitamin D (200 to 400 IU) but high amounts of preformed

retinols (5,000 to 10,000 IU). This pales in comparison to a

tablespoon of modern cod liver oil, which contains sub-physiological

amounts of vitamin D (400 to 1200 IU) but supra-physiological amounts

of completely preformed retinols (5,000 to 15,000 IU or in some cases

30,000 IU).

Cannell

and

In summation, autistic children should be given enough vitamin D to

get their 25(OH)D levels up to the mid to high range of normals, that

is, 70 ng/ml (175 nmol/L in countries that use the metric system).

In the absence of sun exposure, this usually requires long-term

administration of about 1,000 IU/day per 20 pounds of body weight

with a loading dose of 2,000 IU of vitamin D/day for every 20 pounds

of body weight for the first two weeks. As individual variation in

response is very high, they should have 25(OH)D blood tests every

month until their level has stabilized around 70 ng/ml. They should

stop all products containing preformed retinols (vitamin A),

especially cod liver oil.

Cannell, MD

The Vitamin D Council

[Guest guest]

Hi ,

> Hi All this was posted on newWAHB (baby) forums. I was hoping others

> would weigh in with what they know.

If you search the wapfchapterleaders list on onibasu.com, you should

be able to find a recent post by me addressing this. In short,

vitamins A and D exhibit antagonistic, additive and synergistic

functioning, and overall they cooperate together. In fact there is

accumulating evidence that the vitamin D receptor cannot fulfill its

function at all without vitamin A. Vitamin A has a small and almost

negligible effect of decreasing the rise in serum calcium in response

to vitamin D, as he notes, and the study he cites on this suggests it

is of no physiological consequence.

Chris

[Guest guest]

Hi

Thanks i will check Omni. to read the full thread and info.

>

> Hi ,

>

>> If you search the wapfchapterleaders list on onibasu.com, you should

[Guest guest]

Here is the link to Chris's article as well as another one for vitamin D...

_http://www.westonaphttp://wwhttp://www.westhttp://wwhttp://www_

(http://www.westonaprice.org/basicnutrition/vitamina-osteo.html)

_http://www.westonaphttp://wwhttp://www.westhttp://wwwhttp://www._

(http://www.westonaprice.org/basicnutrition/vitamin-d-safety.html)

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