Vit D as an immunosuppressant and bacteria

[Guest guest]

Has this come up before on this list? I can't get over here very often.

I would like some others thoughts. (already posted to on the

chapterleaders list and he's said he's been asked this before....wants

to look further into it later)

The article is long and well-researched. There are good

comments at the end by both the researcher (a molecular biologist) and

others.

The researcher is using the Marshall protocol to control her chronic

fatigue. That protocol calls for very low vit D levels to avoid this

affect.

thanks

Lynn

http://bacteriality.com/2007/09/15/vitamind/#1

<http://bacteriality.com/2007/09/15/vitamind/#1> 1. Vitamin D is not

a vitamin; it is an immunosuppressive steroid. Let'sstart with this

fact: the vast majority of doctors touting the benefitsof vitamin D are

not aware of discoveries made by researchers in thefield of molecular

biology, which have clearly shown that the " vitamin " D derived

from diet and supplements is not a vitamin, but a steroidwith

immunosuppressive properties when elevated.2

<http://bacteriality.com/2007/09/15/vitamind/#footnote_1_53> Thereare

several forms of vitamin D. The form ofvitamin D we get from food, diet,

supplements and sun exposure iscalled D3. D3 is converted by the kidneys

into 25-D, which functions asa steroid. 1,25-D, the activated form of

vitamin D, functions as both asteroid and a hormone. It is produced

inside various types of cells,including those of the immune system and

the kidneys, as well as inresponse to sunlight. In healthy individuals,

the kidneys continuallyconvert 25-D into its active form, 1,25-D.3

<http://bacteriality.com/2007/09/15/vitamind/#footnote_2_53> 4

<http://bacteriality.com/2007/09/15/vitamind/#footnote_3_53> According

to a paper

<http://www.bioone.org/perlserv/?request=get-abstract & doi=10.1095%2Fbiol\

reprod.106.054056 & ct=1> published by the Institute of Biomedical

Research in Birmingham,England, " The active form of vitamin D,

[1,25-D] is a potentimmunomodulatory seco-steroid " meaning that it

is a steroid-likemolecule which is able to control the activity of the

immune system. " 5

<http://bacteriality.com/2007/09/15/vitamind/#footnote_4_53>

Molecularmodeling has shown that the hormonal 1,25-D form binds and

activatesthe Vitamin D Receptor. The Vitamin D Receptor plays a

fundamental rolein the body. It transcribes 913 genes, and researchers

at McGillUniversity in Canada just released a paper

<http://mend.endojournals.org/cgi/content/full/19/11/2685> saying it

may actually transcribe 27,091.6

<http://bacteriality.com/2007/09/15/vitamind/#footnote_5_53> But, the

Vitamin D Receptor also performs another critical function –it

serves as a switch that regulates the activity of the innate

immunesystem.7

<http://bacteriality.com/2007/09/15/vitamind/#footnote_6_53> 8

<http://bacteriality.com/2007/09/15/vitamind/#footnote_7_53> 9

<http://bacteriality.com/2007/09/15/vitamind/#footnote_8_53> A

molecular model comparing the structure of 25-D and of 1,25-D10

<http://bacteriality.com/2007/09/15/vitamind/#footnote_9_53> According

to recent molecular models

<http://autoimmunityresearch.org/transcripts/marshall_bio21_2006.pdf>

,the steroid 25-D binds the Vitamin D Receptor and affects the

activityof the immune system as well, but in a manner opposite to

1,25-D. Whenthe steroid 25-D binds the Vitamin D Receptor, it decreases

theactivity of the receptor, causing the innate immune system to slow

downand shut off. This effect begins around 20 ng/ml and

graduallyincreases with higher levels of 25-D, until the VDR becomes

completelyblocked.11

<http://bacteriality.com/2007/09/15/vitamind/#footnote_10_53> Atthe

moment, most researchers understand that 1,25-D activates theVitamin D

Receptor. However, they are unaware of the models whichdemonstrate that

25-D has the opposite effect. Consequently, they donot understand that

when people start to supplement with extra vitaminD (which is converted

into 25-D) the Vitamin D Receptor begins to turnoff, not on. Mostof

these researchers are also unaware of a new understanding about thecause

of many chronic diseases. As a person falls ill with a chronicdisease,

L-form bacteria <http://bacteriality.com/2007/08/15/l-forms/> begin to

live inside the cells of the immune system and in various tissues.12

<http://bacteriality.com/2007/09/15/vitamind/#footnote_11_53> 13

<http://bacteriality.com/2007/09/15/vitamind/#footnote_12_53> These

bacteria create proteins that, just like elevated 25-D, are able to bind

and block the Vitamin D Receptor.14

<http://bacteriality.com/2007/09/15/vitamind/#footnote_13_53> Together,

elevated 25-D and bacterial proteins block the ability of theVitamin D

Receptor to turn on the immune system more than eithersubstance alone.