Re: Risk factors for heart disease

[Guest guest]

hi Chris

this is a great diagram! it is easy to follow and informative. would it be

appropriate to

connect " stress " and " inflammation " ? certain sterols that are increased by

stress trigger

inflammation. it might make the chart a bit cluttered, however.

Nice job! Good luck w/your presentation!

[Guest guest]

I like it. It helps me to understand the situation much better. However, I'd

love to see a companion diagram that shows how the WAPF diet improves the

situation.

We've been WAPF for about 6 years due to my husbands extreme cardiovascular

disease. Although he still has the disease, I truly believe that our diet is

improving his health and will lengthen his life. Nevertheless, even though he

goes along with the diet since I am the food grower/food buyer/food maker, I

love to show him things to keep trying to convince him. Having a companion

chart that shows how traditional diets improve the situation would be valuable.

Thanks.

Marcie Kinney Adkins

Adkins Family Farm, Brevard County, Florida

Risk factors for heart disease

I put together a diagram for an upcoming presentation on cholesterol and heart

disease. Feel

free to take a look. Feedback and suggestions for improvement welcome!

K.

http://farm3.static.flickr.com/2149/2284154228_d1e3c60fc6_b.jpg

[Guest guest]

On 2/22/08, chriskjezp <chriskresser@...> wrote:

> I put together a diagram for an upcoming presentation on cholesterol and

> heart disease. Feel

> free to take a look. Feedback and suggestions for improvement welcome!

>

> K.

>

> http://farm3.static.flickr.com/2149/2284154228_d1e3c60fc6_b.jpg

Looks very good.

I'm wondering why you have the dietary issues going through nutrient

deficiencies on their way to oxidative stress. High PUFA contributes

to oxidative stress directly, not through inducing a nutrient

deficiency -- are you trying to say that these must be combined with

(relative) nutrient deficiencies in order to result in oxidative

stress? If so, it isn't clear from the chart.

Also, you can add an arrow between sedentary lifestyle and NO

inhibition, because exercise promotes increased shear stress against

endothelial cells, which is the primary inducer of nitric oxide

synthase.

Chris

[Guest guest]

On 2/22/08, Masterjohn <chrismasterjohn@...> wrote:

> On 2/22/08, chriskjezp <chriskresser@...> wrote:

> > I put together a diagram for an upcoming presentation on cholesterol and

> > heart disease. Feel

> > free to take a look. Feedback and suggestions for improvement welcome!

> >

> > K.

> >

> > http://farm3.static.flickr.com/2149/2284154228_d1e3c60fc6_b.jpg

Also, in my opinion and perhaps others can chime in, I think this will

make a rather crowded power point slide, and it may work well as a

summary, but you might (if you haven't already planned to do so) want

to break it down into smaller sections as you talk about each one.

You could, for example, go back to this slide before each section,

then highlight the area you are talking about, then go to a slide that

shows a closeup of that area in a more simple diagram.

Chris

[Guest guest]

> Also, in my opinion and perhaps others can chime in, I think this will

> make a rather crowded power point slide, and it may work well as a

> summary, but you might (if you haven't already planned to do so) want

> to break it down into smaller sections as you talk about each one.

> You could, for example, go back to this slide before each section,

> then highlight the area you are talking about, then go to a slide that

> shows a closeup of that area in a more simple diagram.

That's exactly what I planned to do. I will introduce this diagram to begin

with, then set it up

so that when I click on a particular area of the chart it will take me to a

slide with more

detail, or a more simple diagram.

I agree that it's way too busy as a slide, except for a summary.

Thanks,

Chris

[Guest guest]

> I'm wondering why you have the dietary issues going through nutrient

> deficiencies on their way to oxidative stress. High PUFA contributes

> to oxidative stress directly, not through inducing a nutrient

> deficiency -- are you trying to say that these must be combined with

> (relative) nutrient deficiencies in order to result in oxidative

> stress? If so, it isn't clear from the chart.

>

> Also, you can add an arrow between sedentary lifestyle and NO

> inhibition, because exercise promotes increased shear stress against

> endothelial cells, which is the primary inducer of nitric oxide

> synthase.

>

There is an arrow going from PUFAs directly to oxidative stress, though it's

somewhat lost

in all the busyness. I guess I could also make arrows from sugar and refined

carbs to

oxidative damage, because high blood glucose contributes to gly-LDL? Thanks for

the

heads up on sedentary lifestyle & NO inhibition - I forgot to add that.

K.

[Guest guest]

>

> hi Chris

>

> this is a great diagram! it is easy to follow and informative. would it be

appropriate to

> connect " stress " and " inflammation " ? certain sterols that are increased by

stress trigger

> inflammation. it might make the chart a bit cluttered, however.

>

> Nice job! Good luck w/your presentation!

>

>

Thanks ! Yes, I think I could definitely make an arrow between stress and

inflammation.

Thanks for pointing that out.

Chris

[Guest guest]

I agree with Kris on the slide. However, I think it will be nice to

have this diagram in such a way that clicking on each area will take

you directly to the section dwelling on the area you are discussing and

a 'Return' arrow that takes you back to this network diagram any time

you need to do that at will.

Otherwise I think it is a great presentation summary.

Joe

> > > I put together a diagram for an upcoming presentation on

cholesterol and

> > > heart disease. Feel

> > > free to take a look. Feedback and suggestions for improvement

welcome!

> > >

> > > K.

> > >

> > > http://farm3.static.flickr.com/2149/2284154228_d1e3c60fc6_b.jpg

>

> Also, in my opinion and perhaps others can chime in, I think this will

> make a rather crowded power point slide, and it may work well as a

> summary, but you might (if you haven't already planned to do so) want

> to break it down into smaller sections as you talk about each one.

> You could, for example, go back to this slide before each section,

> then highlight the area you are talking about, then go to a slide that

> shows a closeup of that area in a more simple diagram.

>

> Chris

>

[Guest guest]

The simplest answer to your question is that the WAPF virtually eliminates the

primary

dietary risk factors listed at the top of the chart. Assuming your husband

isn't smoking, is

exercising regularly (to whatever extend appropriate for his particular

condition) and is

managing his stress, then the WAPF diet takes care of the other major risk

factor.

Of course the WAPF diet doesn't just remove harmful substances from the diet, it

adds

many macro and micronutrients that would be beneficial for heart disease: k2,

vitamin a,

vitamin d, antioxidants/polyphenols, etc. etc.

One thing to note is that stress can cause oxidative damage, rho activation, NO

inhibition,

increased blood clotting and endothelial injury (all major causes of CHD)

entirely on its

own with no help from any other risk factors. I think this continues to be the

untold story

in heart disease.

After all, it's much easier for most people to change their diet than it is to

change their

basic way of relating to themselves and to life. Also, there's not much money

to be made

in stress reduction (the drug-free way, at least) by drug companies.

Perhaps I'll get around to doing a version of the chart you suggest before my

presentation, but I doubt it.

Best,

Chris

--- In , " Marcelle A. Kinney, Ph.D. "

<drkinney@...>

wrote:

>

> I like it. It helps me to understand the situation much better. However, I'd

love to see a

companion diagram that shows how the WAPF diet improves the situation.

>

> We've been WAPF for about 6 years due to my husbands extreme cardiovascular

disease.

Although he still has the disease, I truly believe that our diet is improving

his health and

will lengthen his life. Nevertheless, even though he goes along with the diet

since I am

the food grower/food buyer/food maker, I love to show him things to keep trying

to

convince him. Having a companion chart that shows how traditional diets improve

the

situation would be valuable.

>

> Thanks.

> Marcie Kinney Adkins

> Adkins Family Farm, Brevard County, Florida

> Risk factors for heart disease

>

>

> I put together a diagram for an upcoming presentation on cholesterol and

heart

disease. Feel

> free to take a look. Feedback and suggestions for improvement welcome!

>

> K.

>

> http://farm3.static.flickr.com/2149/2284154228_d1e3c60fc6_b.jpg

>

>

>

>

>

>

[Guest guest]

Thanks! I'm loving hearing all this. It's also helping me put it all together.

I'm a bit of a layman on all this but only have personal experience to guide

me. I just know that the WAPF lifestyle makes sense.

Like you say, I also know that

" One thing to note is that stress can cause oxidative damage, rho activation, NO

inhibition,

increased blood clotting and endothelial injury (all major causes of CHD)

entirely on its

own with no help from any other risk factors. I think this continues to be the

untold story

in heart disease. "

Actually, I wouldn't put it so eloquently. But, genetics also have to play a

big role in this, too.

Thanks

Marcie Kinney Adkins

Adkins Family Farm, Brevard Cty, FL

PS My husband's personal story is that he's never smoked or been overweight

and has always exercized. He doesn't exercize much now (but does walk and go to

the gym) but, he was a marathon runner at the time of his heart attack/stroke.

(Age 38). He's 60 now and has seen more heart blockages and another stroke

since that time.

I'd have to say that stress has been his big problem. And a SAD and AHA diet

until about 6 years ago.

When he had bypass surgery 11 years ago, doctors predicted he'd need another in

8-10 years. Well, a cath 9 months ago showed his arteries to be pretty good

though one they never mentioned before and I didn't even know we had (the remus

(sp?)) needed a stent. That was awesome validation for me that our WAPF diet is

a success.

Wanna 'nother glass of milk, honey?

[Guest guest]

--- In , " Marcelle A. Kinney, Ph.D. "

<drkinney@...>

wrote:

> When he had bypass surgery 11 years ago, doctors predicted he'd need another

in 8-10

years. Well, a cath 9 months ago showed his arteries to be pretty good though

one they

never mentioned before and I didn't even know we had (the remus (sp?)) needed a

stent.

That was awesome validation for me that our WAPF diet is a success.

Marcie

That's great news! Good work keeping your husband healthy. You deserve a round

of

applause.