Guest guest Posted February 19, 2008 Report Share Posted February 19, 2008 I've been reading the articles on your site and other resources on NO and Rho. Leaving statins and cholesterol-lowering drugs aside, I gather than inflammation activated Rho, which strongly inhibits NO. Ox-LDL also inhibits NO, and initiates inflammation (which would again inhibit NO). This is obviously a double-whammy against PUFAs, especially the pro-inflammatory n-6 FAs. I'm aware of other diet and lifestyle factors that lead to oxidative damage, but are there any particular factors that activate Rho? Would it be safe to assume that anything that promotes inflammation will activate Rho and inhibit NO, and thus increase the risk of CHD? Thanks, Chris Quote Link to comment Share on other sites More sharing options...
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