The Cure Autism Now Foundation, Areas for Investigation - Mercury/Mito

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Dear List Members:

In our autism research, there has been a current article published on

the role of mercury toxification and autism. In this paper there is

mention of mercury's affect on mitochondria. Here is an excerpt and the

entire paper can be read from the link below. It would be my

suggestion that anyone with an autistic spectrum and mito dysfunction

child should read this paper. Beth

" Mitochondria: Disturbances of brain energy metabolism have prompted

autism to be

hypothesized as a mitochondrial disorder (Lombard, 1998). There is a

frequent

association of lactic acidosis and carnitine deficiency in autistic

patients, which

suggests excessive nitric oxide production in mitochondria (Lombard,

1998; Chugani et

al, 1999), and again, mercury may be a participant. Methylmercury

accumulates in

mitochondria, where it inhibits several mitochondrial enzymes, reduces

ATP production

and Ca2+ buffering capacity, and disrupts mitochondrial respiration and

oxidative

phosphorylation (Atchison & Hare, 1994; Rajanna and Hobson, 1985; Faro

et al, 1998).

Neurons have increased numbers of mitochondria (Fuchs et al, 1997), and

since Hg

accumulates in neurons of the CNS, an Hg effect upon neuronal

mitochondria function

seems likely - especially in children having substandard mercury

detoxification. "

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FORUM

Theories, Studies, and Correlative Data Reviews For Further Investigation

Autism and Mercury

A paper prepared by Sallie Bernard, Albert Enayati, B.S., Ch.E., M.S.M.E., Heidi , Binstock, Lyn Redwood, R.N., M.S.N., C.R.N.P., Woody McGinnis, M.D.

->download rtf formatted document (447 KB)

->download abstract and tables (88 KB)

contact Sallie Bernard at