Re: New Study Results Cast Doubt on Theory that CCSVI Causes MS

[Guest guest]

A betaseron deficiency didn't cause it either.

>

> This was recently posted and I haven't seen it discussed on MScured. It

> shows that CCSVI MAY BE A RESULT OF MS but not cause MS.

[Guest guest]

I tend to agree, I have never thought that CCSVI was the cause.

Too many other contributing risk factors dont fit into CCSVI and since

people

have symptom relief from have the procedure but not a full blown cure as a

result of the procedure also supports this.

So while I think everyone should probably look into CCSVI procedure when

the risk to possible reward ratio is right for you.

It isnt the easy way out, meaning it doesnt mean that you can just go under

the

knife with ccsvi procedure and dont have to change your diet, and do all the

other

things that can help MS and think your problems are over.

Case in point: I saw someone on youtube talking about getting CCSVI

procedure while drinking diet coke !

On Wed, Apr 20, 2011 at 7:16 AM, wrote:

>

>

> This was recently posted and I haven't seen it discussed on MScured. It

> shows that CCSVI MAY BE A RESULT OF MS but not cause MS..In my own

> s

>

[Guest guest]

What are IVIG infusions? thank you.

________________________________

To: mscured

Sent: Wed, April 20, 2011 10:16:39 AM

Subject: New Study Results Cast Doubt on Theory that CCSVI Causes MS

 

This was recently posted and I haven't seen it discussed on MScured. It

shows that CCSVI MAY BE A RESULT OF MS but not cause MS..In my own

situation, I also have several congenital blood clotting disorders and am on

blood thinners (heparin injections 2x daily) for 15 months and get IVIG

[Guest guest]

what is your caffeine ingestion level ? it decreases brain blood

flow by up to 32% with dose 250mg

W dniu 2011-04-20 16:16, pisze:

>

> This was recently posted and I haven't seen it discussed on MScured. It

> shows that CCSVI MAY BE A RESULT OF MS but not cause MS..In my own

> situation, I also have several congenital blood clotting disorders and

> am on

> blood thinners (heparin injections 2x daily) for 15 months and get IVIG

> infusions every 3 weeks for the past 16 months. Since that time, I have

> finally had no recurrent relapses since Jan 2010 and no new lesions

> based on

> 3 separate brain MRIs in 2010 and 2011. I also have significantly less

> symptoms in many areas. My MRV showed a congenital defect in the circle of

> Willis but it was not a Hubbard Foundation approved MRV; and Venous

> Doppler

> evaluation in Jan of 2010.

>

> Source " http://www.msfocus.org/news-details.aspx?newsID=93

>

> New Study Results Cast Doubt on Theory that CCSVI Causes MS

>

> 4/13/2011

>

> A just-released study on the relationship between MS and chronic cerebral

> venous insufficiency (CCSVI) found that CCSVI may be a result of MS, not a

> cause, according to researchers.

>

> A narrowing of the extracranial veins that restricts the normal outflow of

> blood from the brain, CCSVI has been a much-discussed topic in the MS

> community and among healthcare providers since it was first publicly

> described as a possible cause of the disease in October 2009.

>

> The study, conducted by University at Buffalo (UB) researchers, appears in

> the current issue of Neurology, the journal of the American Academy of

> Neurology. Zivadinov, M.D., PhD, associate professor of

> neurology in

> the UB School of Medicine and Biomedical Sciences and president of the

> International Society for Neurovascular Disease, is first author on the

> paper.

>

> " Our results indicate that only 56.1 percent of MS patients and 38.1

> percent

> of patients with a condition known as clinically isolated syndrome

> (CIS), an

> individual's first neurological episode, had CCSVI.

>

> " While this may suggest an association between the MS and CCSVI,

> association

> does not imply causality. In fact, 42.3 percent of participants classified

> as having other neurological diseases (OND), as well as 22.7 percent of

> healthy controls involved in the study, also presented with CCSVI.

>

> " These findings indicate that CCSVI does not have a primary role in

> causing

> MS, " says Zivadinov. " Our findings are consistent with increased

> prevalence

> of CCSVI in MS, but substantially lower than the sensitivity and

> specificity

> rates in MS reported originally by the Italian investigators. "

>

> CCSVI is a complex vascular condition discovered and described by Paolo

> Zamboni, MD, from Italy's University of Ferrara. It is characterized by

> narrowing of vessels draining blood from the cranium. Zamboni hypothesized

> that this narrowing restricts the normal outflow of blood from the brain,

> resulting in alterations in the blood flow patterns within the brain that

> eventually cause injury to brain tissue and degeneration of neurons,

> leading

> to MS.

>

> Zamboni's original investigation in a group of 65 patients and 235

> controls

> showed that CCSVI appeared to be strongly associated with MS,

> increasing the

> risk of having MS by 43 fold.

>

> The results of the UB study are based on 499 participants in the Combined

> Transcranial and Extracranial Venous Doppler Evaluation (CTEVD) study,

> which

> began at the university in April 2009.

>

> The study group consisted of 289 persons with MS, 163 healthy controls, 26

> with OND and 21 with CIS.

>

> MS participants also were defined by disease type: relapsing-remitting

> (RR),

> secondary progressive (SP), primary-progressive (PP),

> progressive-relapsing

> (PR) and MS with neuromyelitis optical (NMO) - a type of MS that

> affects the

> optic nerves and spinal cord exclusively.

>

> All participants underwent transcranial and extracranial echo-Doppler

> scans

> of the head and neck. Persons were considered " CCSVI-positive " if they met

> two or more of five venous hemodynamic (VH) criteria.

>

> Prevalence rates were calculated in three groupings: only subjects with

> positive and negative CCSVI diagnoses; only borderline cases included

> in the

> negative group; and subjects who fulfilled any of the five criteria.

>

> When only positive and negative CCSVI cases were considered, results

> showed

> a CCSVI prevalence of 62.5 percent in MS patients, 45.8 percent in those

> with OND, 42.1 percent in CIS, and 25.5 percent in healthy controls.

>

> When borderline cases were included as negative for CCSVI, prevalence

> figures were 56.1 percent in MS patients, 42.3 percent in those with OND,

> 38.1 percent with CIS and 22.7 percent in healthy controls.

>

> When all cases that met at least one of the five VH criteria were included

> in the analysis, CCSVI prevalence was 81.3 percent in MS cases, 76.2

> percent

> in CIS patients, 65.4 percent in OND cases and 55.2 percent in healthy

> controls.

>

> The highest prevalence was seen in relapsing primary-progressive MS (89.4

> percent), followed by non-relapsing secondary-progressive MS (67.2

> percent),

> NMO (66.6 percent), primary-progressive MS (54.5 percent) and

> relapsing-remitting MS (49.2 percent). CCSVI prevalence was substantially

> higher in progressive MS than in non-progressive MS patients. In addition,

> patients with a progressive MS disease subtype had higher CCSVI prevalence

> than those with non-progressive MS.

>

> " The higher prevalence of CCSVI in progressive MS patients suggests that

> CCSVI may be a consequence, rather than a cause, of MS, " says Bianca

> Weinstock-Guttman, M.D., co-principal investigator of the study and UB

> professor of neurology. Therefore, the possibility that CCSVI may be a

> consequence of MS progression cannot be excluded and should be further

> investigated.

>

> " Several studies have reported that patients with progressive MS show

> decreased blood flow through the brain's neuronal tissue, indicating that

> CCSVI may be secondary to reduced perfusion, " says Weinstock-Guttman. " In

> addition, we recently showed an association between the severity of CCSVI

> and reduced cerebral blood flow in brain parenchyma of MS patients in an

> published pilot study. "

>

> E. Ann Yeh, MD, UB assistant professor of neurology and a major

> collaborator

> on the study, noted that of the 10 pediatric MS patients who

> participated in

> the study, five presented with CCSVI (50 percent), yielding prevalence

> similar to that in adult MS patients.

>

> " Although the sample size was too small to draw any firm conclusions,

> these

> results suggest that CCSVI is also present in children and is not the

> result

> of aging, " she says.

>

> Concludes Zivadinov: " The differences between our study, the original

> Italian CCSVI study and other recently published studies also

> emphasize the

> need for a multimodal approach for the assessment of CCSVI. In addition to

> Doppler sonography, use of selective venography, magnetic resonance

> venography and intraluminal Doppler methods can provide more evidence for

> the true prevalence of CCSVI in MS. "

>

> The study was supported by the Buffalo Neuroimaging Analysis Center, Baird

> MS Center and the s Neurological Institute, all from UB, as well

> as the

> Direct MS Foundation, the Jacquemin Family Foundation and more than 500

> individual donors.

>

> http://www.msfocus.org/news-details.aspx?newsID=93

>

>