Guest guest Posted June 26, 2009 Report Share Posted June 26, 2009 I haven't been following this thread very closely so don't know if this has been talked about or not. Accidently found this when I was searcing for something else on the Linus ing Institute site. Thought it was really interesting. Pellagra – Niacin Deficiency The late stage of severe niacin deficiency is known as pellagra. Early records of pellagra followed the widespread cultivation of corn in Europe in the 1700's (1). The disease was generally associated with poorer social classes whose chief dietary staple consisted of cereals like corn or sorghum. Pellagra was also common in the southern United States during the early 1900's where income was low and corn products were a major dietary staple (5). Interestingly, pellagra was not known in Mexico, where corn was also an important dietary staple and much of the population was also poor. In fact, corn contains appreciable amounts of niacin, but it is present in a bound form that is not nutritionally available to humans. The traditional preparation of corn tortillas in Mexico involves soaking the corn in a lime (calcium oxide) solution, prior to cooking. Heating the corn in an alkaline solution results in the release of bound niacin, increasing its bioavailability (6). The most common symptoms of niacin deficiency involve the skin, digestive system, and the nervous system (2). The symptoms of pellagra were commonly referred to as the four D's: dermatitis, diarrhea, dementia, and death. In the skin, a thick, scaly, darkly pigmented rash develops symmetrically in areas exposed to sunlight. In fact, the word " pellagra " comes from the Italian phrase for rough or raw skin. Symptoms related to the digestive system include a bright red tongue, vomiting, and diarrhea. Neurologic symptoms include headache, apathy, fatigue, depression, disorientation, and memory loss. If untreated, pellagra is ultimately fatal (3). Laree _________________________________________________________________ Windows Live™: Keep your life in sync. http://windowslive.com/explore?ocid=TXT_TAGLM_WL_BR_life_in_synch_062009 Quote Link to comment Share on other sites More sharing options...
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