Prokarin and CCSVI compatibility

[Guest guest]

by Elaine DeLack

After learning about CCSVI and Dr. Zamboni's Liberation treatment, I found a

very interesting fact that connected the benefits seen with Prokarin and the

CCSVI which explains why the veins are stenosing (narrowing) and twisting and

how this can be prevented. Let me explain. Prior to developing Prokarin, I used

injections of vitamin B12 (cyanocobalamin) and adenosine monophosphate. Then I

switched to Prokarin and I was able to resolve all of my MS symptoms. Prokarin's

active ingredients are histamine diphosphate and caffeine citrate. Histamine

diphosphate is a histamine 2 (H2) agonist (meaning it stimulates H2 receptors).

H2 receptor stimulation stimulates production of cyclic adenosine monophosphate

(cAMP) in the body. Caffeine inhibits the breakdown of cAMP.

So here is the interesting fact that explains why Prokarin and the Liberation

Treatment could have great potential together. Dr. Zamboni found that the

internal jugular vein is often narrowed and twisted in MS patients resulting in

decreased blood flow. Dr. Zamboni has hypothesized that iron deposits are

causing these veins to varicose (narrowing and twisting). An FDA recognized

treatment for varicose veins was adenosine monophosphate. Adenosine

monophosphate like cAMP stimulates the cells to stop growing and to mature into

working cells (called differentiation). If you don't have enough cAMP activity,

the cells of the blood vessels called endothelial cells will just keep

proliferating resulting in too much cell growth which causes crowding in the

lumen (opening of the vein that allows blood to flow through) and this crowding

causes the veins to twist. This results in a varicose vein which is what is seen

in CCSVI. Research using the umbilical cord has shown that the veins will

varicose if transferrin, transferrin receptor binding protein, or monoamine

oxidase-A (MAO-A) is deficient. MAO-A is the mitochondrial enzyme that converts

histamine into H2 and MAO-A also is involved in the production of transferrin

and transferrin receptor binding protein. Transferrin and transferrin receptor

binding protein is needed for to prevent iron deposits. Dr. Zamboni has found

iron deposits in the area of the veins that are narrowing and twisting. These

iron deposits cause free radical damage in the veins and this results in cell

damage. This causes new cell growth of the cells lining the inside of the veins.

If you have deficient cAMP activity, the cell growth will go unchecked causing

the stenosis and twisting of the veins.

The Liberation treatment involves angioplasty which uses a balloon type

mechanism to open the lumen of the vein or placing a stent in the vein to hold

it open. The problem is that often the vein will restenose, requiring the

procedure to be repeated. Also if the veins are stenosing in one area, they

probalby are stenosing in other areas as well that can't be accessed.

So I believe that the rate of restenosis could be greatly reduced and greater

improvements may be seen with the Liberation treatment if Prokarin were used in

conjunction with the placement of a stent or angioplasty.