Re: [lowdosenaltrexone] Re: LDN +

[Guest guest]

In regard to daytime dosing, of all the clinical trials of LDN conducted with

humans, only one used daytime dosing--a German study with a group of MS

patients. While about a third of the group did experience limited benefit, this

is the comment made about the trial by Dr. Gluck, webmaster of

http://ldninfo.org:

Unfortunately, because of some early complaints of sleep disturbance, the

principal investigator of this trial switched all of the study group to taking

LDN at 9 am in the morning, a questionable dosage time. It is generally

recognized that the most effective time to take LDN is at bedtime, between 9 pm

and 3 am, due to the fact that the endorphins for each day are always produced

at their peak rate in the pre-dawn hours. A 9 am dosage time, as was used in

this trial, might conceivably suppress—rather than boost—a patient's immune

system.

In a presentation made by Dr. Bernard Bihari in 2002, he gave this perspective

on LDN dosing:

What we did was we measured the endorphin rises with different doses of

Naltrexone. We got the same rise with 50 mg, 10 mg, 5 mg, and 3 mg. What we were

looking for was the smallest dose that could produce a full naltrexone-induced

endorphin rise, if taken late at night. The reason the hour is important is that

90% of the endorphins are made in the middle of the night, between 2 and 4 in

the morning. If a small dose of naltrexone is taken in the late evening,

generally at bedtime, generally endorphin production is boosted as much as

threefold, 300%. The naltrexone itself is gone in about 3 hours, but the

endorphins remain elevated all the next day. So the naltrexone doesn't

significantly block the endorphins but does cause them to rise.