RE: Fw: Daily pill could or even reverse Multiple Sclerosis

[Guest guest]

It's interesting isn't it?This was posted last week and whilst it's interesting,

I'll just be interested to find out what side effects etc come with this

one.

'What we do in life, echoes through eternity.'

MARCUS AURELIUS (121 - 180 A.D.)

To: MSnaturally@...; MSersLife ; mscured ;

MSChristian ; MS_Community ; Josbyz@...;

chris@...

From: tbayuk@...

Date: Tue, 11 Oct 2011 12:10:49 -0400

Subject: Fw: Daily pill could or even reverse Multiple Sclerosis

Subject: Daily pill could or even reverse Multiple Sclerosis

Daily pill 'could stop or even REVERSE multiple sclerosis'

Researchers in Canada discover low levels of brain chemicals in sufferers

Trials are already underway and could speed the drug's release for general use

By Daily Mail Reporter

Last updated at 3:49 PM on 23rd September 2011

Comments (25)

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Breakthrough: An effective treatment could be available within six years

Doctors have made an 'exciting' breakthrough that could lead to a new treatment

to stop - or even reverse the symptoms - of multiple sclerosis.

Researchers have discovered that people with MS have significantly lower levels

of brain chemicals called neuro-steroids.

Neuro-steroids help build brain cells and maintain their function, connecting

different areas of activity in the brain.

Scientists and neurologists at the University of Alberta in Edmonton, Canada

believe that it would be possible to replace the missing chemical with a daily

pill that would represent a completely different way of dealing with the disease

that affects more than 85,000 people in the UK.

Dr Power announced the discovery in a research paper in the latest issue

of Brain.

He said: 'This frankly is an exciting breakthrough and has huge potential. The

role of neurosteroids in the brain has been known for some time but no one

thought - until now - that they might play a role in MS.'

The link with the disease was made when his team tested the brains of 16

patients from Alberta - which has the highest levels of MS in the world - and

discovered that they had significant lower levels of a particular neuro-steroid

allopregnanolone compared to a group of patients who had died from other

diseases.

Dr Power's team were excited because trials using allopregnanolone - which is

derived from cholesterol and is linked to vitamin D - are already underway in

epilepsy and depression.

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'The chemical is already available which speeds up the process that could

eventually get this into humans with MS,' he said.

Researchers are interested in the vitamin D link because it has been established

that there are higher levels of MS in Northern areas of the world such as

Scotland where reduced levels of the vitamin have been linked to less exposure

to sunlight.

When mice with MS were treated with allopregnanolone it had a significant

effect, reducing inflammation levels in the brain and repairing nerve fibres.

In MS the myelin sheath around nerves is destroyed by the disease which is

triggered by the immune system 'over reacting' and attacking healthy cells

rather than invading infections and diseases.

MULTIPLE SCLEROSIS

Multiple Sclerosis is a complex condition which can be difficult to diagnose

because it presents in many different forms.

Symptoms can include problems with vision, balance and dizziness, fatigue as

well as bladder, speech and swallowing difficulties.

The condition can also affect memory and thinking and impact on a sufferer's

emotions.

In severe cases a person with MS will be unable to walk.

Most people will not suffer the same symptoms and they will not suffer all of

them at the same time.

MS is usually diagnosed in adults between 20 and 40 years old and is more

prevalent in women.

Treatments up until now have included drug, exercise and physiotherapy alongside

diet and alternative therapies.

MS is an inflammatory disease which damages the tissue around the brain and the

spinal cord, this affects the ability of cells to communicate leaving the body

unable to respond to instructions from the brain.

MS in its severest form can cause loss of mobility but the Canadian researchers

found that the mice given the steroid were found to have increased levels of

mobility over a 30 day period following the start of treatment.

Dr Power said: 'Overall we found that the mice showed a 50 per cent reduction in

MS disease severity in the brain.'

At present there a number of drugs that slow the progression of MS but after a

period of time many patients 'fail' on the treatments and their disease

continues to progress.

Dr Power believes that regular treatment with allopregnanolone - and possibly

other neurosteroids halt the disease and can reverse some of the symptoms.

He said: 'We were surprised by our initial discovery that this neurosteroid was

present in reduced levels in MS patients and then amazed to discover that when

we used it as treatment it had such significant effects.'

Funding for the research came from the Canadian Government and the country's MS

Society.

Dr Power is now hoping to get Government or drug funding to

start the first stages of human

trials with allopregnanolone within the next couple of years.

He said: 'Initially we will be looking that it is safe to take. But to some

extent that work has been done because of the trials in other disease areas. Our

research on mice showed no toxicity.

'If we overcome that hurdle - which we should then we would be onto stage two

trials to establish that it works as a treatment.

'We are talking about it being at least six or seven years away as a treatment

but I am optimistic about our chances even though there are a number of hurdles

to overcome.'

Explore more:

Places: Scotland, United Kingdom, Canada

Read more:

http://www.dailymail.co.uk/health/article-2040959/Daily-pill-stop-reverse-multip\

le-sclerosis.html#ixzz1YtbbeTbo

[Guest guest]

Interesting, is anyone taking pregnenolone? This could explain why the

link to low dhea levels and ms

You can get a blood test from lef to check your levels.

>

[Guest guest]

Side effects? Why would you think there would be side effects?

>

Restoring low levels of a naturally occurring compound should have the

lowest or no side effects at all.

[Guest guest]

,

I'm curious to learn more about your comment regarding DHEA and MS. I don't

recall hearing about DHEA before, but I'm always open to learning about new

tests. I found this reference on the web for DHEA and MS:

http://www.lef.org/protocols/neurological/multiple_sclerosis_01.htm

Do you have any other info? I would be glad to request the test from my

doctor (or do it myself) if I felt it was beneficial.

Thanks!

Larry

> **

>

>

> Interesting, is anyone taking pregnenolone? This could explain why the

> link to low dhea levels and ms

>

> You can get a blood test from lef to check your levels.

> >

>

>

--

" I ask God not for the grace to see what lies ahead but for the grace to

accept whatever comes. "

-- Merton

[Guest guest]

I have read several things, but it's been a while. Just spend some more time on

google.

It does make sense that ms usually shows up around age 30-40 and that is when

dhea levels plummet. May e it is the rise in inflammation from low dhea combined

with immune imbalance from low dhea.

But pregnenolone is the precursor to dhea. So low preg and low dhea starts to

make sense.

You can get a preg and dhea test from lef. I got mine tested and it was very

low, so I started taking it and feel 100 times better. I might start taking preg

too

>

[Guest guest]

It's a drug and is artificially made.....therefore (judging by previous

experiences and knowledge), I ask the question regarding the side effects.It

makes perfect sense to me to ask the question.

'What we do in life, echoes through eternity.'

MARCUS AURELIUS (121 - 180 A.D.)

To: mscured

From: ortcloud@...

Date: Tue, 11 Oct 2011 17:17:07 -0700

Subject: Re: Fw: Daily pill could or even reverse Multiple Sclerosis

Side effects? Why would you think there would be side effects?

>

Restoring low levels of a naturally occurring compound should have the

lowest or no side effects at all.

[Guest guest]

allopregnanolone? a drug? Why would you say that?

Do you consider insulin a drug? It is artificially made for diabetics and is

sold as a drug but I don't consider it a drug, it is naturally occurring in the

body and in diabetes is low, so restoring levels to normal would be very

different than some foreign synthetic drug that was never in the body.

allopregnanolone is the same thing, it is naturally occurring and they would be

supplementing to bring back levels, but to just lump that in with toxic foreign

synthetic drugs doesn't make sense to me.

>

[Guest guest]

oh wellwe'll just have to agree to disagree then - I just do not trust BIG

Pharma....and perhaps I've just had far worse outcomes and experiences from what

they insist is something which is good for us.Unless I've been misled, this

report (which I posted on my group site when it first came out last week),

apologies, but it is no supplement from what was written in the article.As I

said, agree to disagree - I truly am not in this to change anyone else's

viewpoint so would like to respectfully just end it here thanks.

'What we do in life, echoes through eternity.'

MARCUS AURELIUS (121 - 180 A.D.)

To: mscured

From: ortcloud@...

Date: Wed, 12 Oct 2011 16:42:16 -0700

Subject: Re: Fw: Daily pill could or even reverse Multiple Sclerosis

allopregnanolone? a drug? Why would you say that?

Do you consider insulin a drug? It is artificially made for diabetics and is

sold as a drug but I don't consider it a drug, it is naturally occurring in the

body and in diabetes is low, so restoring levels to normal would be very

different than some foreign synthetic drug that was never in the body.

allopregnanolone is the same thing, it is naturally occurring and they would be

supplementing to bring back levels, but to just lump that in with toxic foreign

synthetic drugs doesn't make sense to me.

[Guest guest]

So you would also consider coq10, glucosamine and Sam-e all drugs?

I don't trust big pharma either but if they made co-q10 or glucosamine I

wouldn't care.

>

[Guest guest]

I read this web site regularly and everytime I hear of a supplement that

could help MS, or one of my many symptoms I search the web and purchase it.

Sometimes I am overwelmed by all the supplements I am taking. Does anyone

feel the same?

[Guest guest]

I periodically have MRIs and it shows the same...Consistant with previous

MS Diagnosis, yet I am getting worse. I asked my neuro and he says that

there is damage that does not show on the MRI, it is deeper in the brain.

Tammy