low dose benadryl

[Guest guest]

I'm going to start with the background that led to my trying benadryl at low

doses:

I was researching a question on another yahoo group and came across the

following that showed an antihistimine being tested for alzhimers prevention:

http://www.ehow.com/way_5594690_antihistamines-alzheimer-prevention.html

My responce to the question included the following:

" Do let us know if you get any perceved benifit in unexpected areas,

specifically any improvement in cognative areas. "

I got these two responces:

" My father's doctor had him take Benadryl when he had Parkinson's (which

seems to be mito related in our family). My dad didn't have any

allergies, but it seemed to help with cognitive issues. I have started using a

very small amount of Benadryl (a few drops from the dye-free capsules) and so

far am fine. It really helped me with my constant sleepiness which is the

opposite of what you would expect from Benadryl

and

" My son has had WONDERFUL results with both natural and over the counter

histamine blockers. He has had seizures for 9 years that were never controlled

by medicine and most medicines made him 100% worse. We tried the histamine

blockers that the neuro's had always told us to stay away from. The 2 that has

made the biggest difference is dye free benedryl and atarax. YOU DO NOT TAKE

THESE 2 Together. Both these do cross the blood brain barrier and for my son

this is what HE NEEDED. HE IS NOW SEIZURE FREE first time in 9 years!!! The

medical world has had no clue what happened to my son. "

So I started 1 drop from the dye free benadryl (approximately 5 mg) every three

hours looking for cognative improvement.

what I got was way more than cognative improvement. This is where it gets

complicated. I'm going to do this in short points.

MS is the result of premature or excessive apoptosis (cell death) of cells

involved in remylination, see here:

http://www.ncbi.nlm.nih.gov/pubmed/10928289

My disorder also causes excessive apoptosis of skelatal muscle cells and causes

major symptoms when the body tries to rid itself of the debris.....Those

symptoms have disappeared unless I increase my activity level and effort level

to twice what I was able to sustain before....and when I do crash, recovery is

days rather than weeks.

My observations and more detail are posted here:

http://www.spacedoc.com/board/viewtopic.php?t=1961

OK now on to what I have found to explain this:

First Apoptosis is a process and one of the steps is mitochondrial swelling, see

here:

http://www.google.com/#sclient=psy-ab & hl=en & q=mitochondrial+swelling+and+apoptos\

is & oq=apoptosis+and+mitochondrial+swelling & aq=0bK & aqi=g-bK1 & aql= & gs_l=serp.1.0.0\

i8i30.13579.38813.0.44094.30.23.0.0.0.1.2000.15251.2-6j2j3j4j1j1j3j1.21.0...0.0.\

vjn6CDKwwUQ & pbx=1 & bav=on.2,or.r_gc.r_pw.,cf.osb & fp=eb732e148e99a4bb & biw=1005 & bih\

=540

Now here is the important study showing that some antihistimines inhibit

mitochondrial swelling and therefor inhibit cell death by apoptosis.

http://www.sciencedirect.com/science/article/pii/0006300261904498

and the stanford study of antihistimines and MS

http://www.ctsaip.org/create-pdf.cfm?id=5893

That's it in a nutshell....I do have more on antihistimines in cancer and other

diseases that provide more detail but google works well....