Guest guest Posted January 3, 2008 Report Share Posted January 3, 2008 This can't happen any too soon! New Method To Take Insulin Orally Diabetes treatment could get a whole lot easier to swallow. Dr. Doyle, assistant professor of chemistry at Syracuse University has designed, tested, reproduced and patented a system for delivering insulin through an oral pill. The system could potentially be used by humans battling diabetes. With Doyle's method, they could simply swallow a vitamin pill. More than 21 million individuals in the United States have diabetes, yet taking insulin orally has not been possible because it must go through the gastrointestinal tract, which prevents it from reaching the bloodstream. Being able to orally receive insulin would drastically change the lives of diabetics and the scope of the diseases' treatment, researchers said. The innovation in Doyle's research is that they have found a way to attach the insulin to vitamin B-12. The vitamin protects the insulin as it journeys through the gastrointestinal tract in a " Trojan horse " strategy. " It's really like the holy grail of diabetes research.in terms of treatable things, " said Tony Vortherms, a graduate student who worked on the project. Now the team will determine whether they can attach more insulin to the vitamin so that it can remain in the bloodstream for 12 hours. The ultimate goal would be for a diabetic to take two insulin pills a day - one in the morning and one at night - which would help them to maintain their metabolic control throughout the day, according to a news release announcing the discovery. " This would be a way to minimize the roller coaster of blood sugar levels the best we can, " Vortherms said. " We still have a long way to go. " The ultimate question is if and when this strategy can be used in humans. It will probably take at least five years before a pharmaceutical company will take interest in the project - which has great commercial possibilities - and test it, Petrus said. The first stage would be a more elaborate test on rats and then trials to determine its effect in humans. Petrus is optimistic. " From what I've seen so far, " she said, " I do believe it's possible. " " The goal of this project would be to give people who are not able to produce insulin on their own at least a base level of insulin in their blood, " Vortherms said. He added that one of the biggest problems currently is the drastic swings in blood sugar levels that diabetics go through daily. The sugar highs and lows over the long term lead to wear and tear on the individuals. Vortherms said he is very interested in the other fields in which oral delivery like this could work and added there was a " decent to good chance " of it being used in humans in the future. In the news release, Doyle said he was pleased because of the rare payoff in scientific research, where results must be tested and re-tested to ensure reproduction. " In the case of insulin, we had a hypothesis, we set about testing our hypothesis and we were rewarded for the effort, " he said. " Having things go your way doesn't happen in science often enough, so when it does it's very rewarding. " Fairchild sees the benefit of removing needles from the equation of diabetic treatment. " The possibility of having an oral insulin medication has tremendous feasibility, particularly with children and in less-developed countries where sterile needles and adequate training - for injection site and frequency, as well as needle disposal - may not always be available, " he said. He added that there is a lot of research being conducted in the field of diabetes treatment and other teams are looking at their own means for getting insulin into the bloodstream without the pain of injections. Article Options Print Print Send to Friend Send to friend This article is part of the following Newsletter This article is also part of the following Category See Diabetes In Control latest newsletter visit our home page. Search Diabetes In Control table with 2 columns and 2 rows Article Title: Article Description: table end Search Browse our other news categories below. A. Lee Dellon, MD | Beverly Price | Birgitta I. Rice, MS | Did You Know | Dr. Bernstein | Dr. Jakes, Jr. | Dr. Varon, DDS | Dr. Fred Pescatore | Dr. Walter Willett | Education | S. Freedland | Evan D. Rosen | Facts | Features | Ginger Kanzer- | Items for the Week | , MD | ph M. Caporusso | a Sandstedt | Plunkett | Leonard Lipson, M.A. | Lester A. Packer | Diane | New Products | Newsflash | Chous, M.A., OD | Philip A. Wood PhD | R. | Sheri R. Colberg PhD | Sherri Shafer | Steve Pohlit | Studies | Test Your Knowledge | Theresa L. Garnero | Tools | Vickie R. Driver | M. Volpone | Looking for a particular Newsletter Issue? Click Here Special Offers aserver/adview Free Newsletter Not Subscribed? Get the FREE Diabetes In Control Newsletter today. Click Here Special Offers aserver/adview New Product Visit our New Products Section Special Offers aserver/adview Free CE Available CE Programs On Diabetes Available Special Offers aserver/adview Jump To: Home | Advertising | All News Categories | Classifieds | Downloads | Education | Features | Feedback | Items of the Week | Links | Most Recent Additions | New Products | NewsFeed | Past Newsletters | Recommend Us | Search | Studies | Subscribe | Test Your Knowledge | This Week's Newsletter | Tools For Your Practice | Writers Archives | Go Way Back Privacy / About DIC / Advertising With Us / Contact DIC Click Here Copyright @ 1999-2006 Diabetes In Control, Inc.. All rights reserved. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 4, 2008 Report Share Posted January 4, 2008 Hi,, do you know Why I am getting two messages from you? regards, Claude Everett American by chance, Californian by choice. Everyone has a disability, some are more aware of it than others. _____ From: blind-diabetics [mailto:blind-diabetics ] On Behalf Of LaFrance-Wolf Sent: Thursday, January 03, 2008 2:10 PM To: Blind-DiabeticsYahoogroups (DOT) Com; Acb-DiabeticsAcb (DOT) Org; Doc Mahaber Dr. (Doc Mahaber Dr.); rayann Myers Subject: article This can't happen any too soon! New Method To Take Insulin Orally Diabetes treatment could get a whole lot easier to swallow. Dr. Doyle, assistant professor of chemistry at Syracuse University has designed, tested, reproduced and patented a system for delivering insulin through an oral pill. The system could potentially be used by humans battling diabetes. With Doyle's method, they could simply swallow a vitamin pill. More than 21 million individuals in the United States have diabetes, yet taking insulin orally has not been possible because it must go through the gastrointestinal tract, which prevents it from reaching the bloodstream. Being able to orally receive insulin would drastically change the lives of diabetics and the scope of the diseases' treatment, researchers said. The innovation in Doyle's research is that they have found a way to attach the insulin to vitamin B-12. The vitamin protects the insulin as it journeys through the gastrointestinal tract in a " Trojan horse " strategy. " It's really like the holy grail of diabetes research.in terms of treatable things, " said Tony Vortherms, a graduate student who worked on the project. Now the team will determine whether they can attach more insulin to the vitamin so that it can remain in the bloodstream for 12 hours. The ultimate goal would be for a diabetic to take two insulin pills a day - one in the morning and one at night - which would help them to maintain their metabolic control throughout the day, according to a news release announcing the discovery. " This would be a way to minimize the roller coaster of blood sugar levels the best we can, " Vortherms said. " We still have a long way to go. " The ultimate question is if and when this strategy can be used in humans. It will probably take at least five years before a pharmaceutical company will take interest in the project - which has great commercial possibilities - and test it, Petrus said. The first stage would be a more elaborate test on rats and then trials to determine its effect in humans. Petrus is optimistic. " From what I've seen so far, " she said, " I do believe it's possible. " " The goal of this project would be to give people who are not able to produce insulin on their own at least a base level of insulin in their blood, " Vortherms said. He added that one of the biggest problems currently is the drastic swings in blood sugar levels that diabetics go through daily. The sugar highs and lows over the long term lead to wear and tear on the individuals. Vortherms said he is very interested in the other fields in which oral delivery like this could work and added there was a " decent to good chance " of it being used in humans in the future. In the news release, Doyle said he was pleased because of the rare payoff in scientific research, where results must be tested and re-tested to ensure reproduction. " In the case of insulin, we had a hypothesis, we set about testing our hypothesis and we were rewarded for the effort, " he said. " Having things go your way doesn't happen in science often enough, so when it does it's very rewarding. " Fairchild sees the benefit of removing needles from the equation of diabetic treatment. " The possibility of having an oral insulin medication has tremendous feasibility, particularly with children and in less-developed countries where sterile needles and adequate training - for injection site and frequency, as well as needle disposal - may not always be available, " he said. He added that there is a lot of research being conducted in the field of diabetes treatment and other teams are looking at their own means for getting insulin into the bloodstream without the pain of injections. Article Options Print Print Send to Friend Send to friend This article is part of the following Newsletter This article is also part of the following Category See Diabetes In Control latest newsletter visit our home page. Search Diabetes In Control table with 2 columns and 2 rows Article Title: Article Description: table end Search Browse our other news categories below. A. Lee Dellon, MD | Beverly Price | Birgitta I. Rice, MS | Did You Know | Dr. Bernstein | Dr. Jakes, Jr. | Dr. Varon, DDS | Dr. Fred Pescatore | Dr. Walter Willett | Education | S. Freedland | Evan D. Rosen | Facts | Features | Ginger Kanzer- | Items for the Week | , MD | ph M. Caporusso | a Sandstedt | Plunkett | Leonard Lipson, M.A. | Lester A. Packer | Diane | New Products | Newsflash | Chous, M.A., OD | Philip A. Wood PhD | R. | Sheri R. Colberg PhD | Sherri Shafer | Steve Pohlit | Studies | Test Your Knowledge | Theresa L. Garnero | Tools | Vickie R. Driver | M. Volpone | Looking for a particular Newsletter Issue? Click Here Special Offers aserver/adview Free Newsletter Not Subscribed? Get the FREE Diabetes In Control Newsletter today. Click Here Special Offers aserver/adview New Product Visit our New Products Section Special Offers aserver/adview Free CE Available CE Programs On Diabetes Available Special Offers aserver/adview Jump To: Home | Advertising | All News Categories | Classifieds | Downloads | Education | Features | Feedback | Items of the Week | Links | Most Recent Additions | New Products | NewsFeed | Past Newsletters | Recommend Us | Search | Studies | Subscribe | Test Your Knowledge | This Week's Newsletter | Tools For Your Practice | Writers Archives | Go Way Back Privacy / About DIC / Advertising With Us / Contact DIC Click Here Copyright @ 1999-2006 Diabetes In Control, Inc.. All rights reserved. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 4, 2008 Report Share Posted January 4, 2008 The thing you are not getting is the ADA American Diabetes Association has become an extension of the AMA American Medical Association, which deplores supplements since they are not classified as a drug, which they get a cut of whenever they prescribe a drug. Doctors do not get rewarrded for recommending or prescribing a vitamin or mineral. The only time you hear from them is when you get all kinds of falacious warnings about the dangers of supplements causing deaths and disabilities, which is almost non-existent by using supplements. In other cases you hear about wasting your money by enriching your urine with vitamins and mineerals with supplements. Afterall that water soluable niacin costs you ten to twenty cents per day. Just leave that stuff alone, and the doctors can treat you for a stroke or heart attack, which is much more rewarding for the doctors, nurses and hospitals. article 2008 ADA Guidelines for Medical Nutrition Therapy The American Diabetes Association (ADA) has updated its guidelines regarding medical nutrition therapy (MNT), including the use of low-carbohydrate diets to prevent diabetes, manage existing diabetes, and prevent or slow the rate of development of diabetes complications. The revised position statement, which is published in the January issue of Diabetes Care, updates those from 2002 and 2004, presenting evidence-based data published since 2000 and grading of recommendations according to the level of evidence available, based on the ADA evidence-grading system. P. Bantle, and colleagues from the ADA.write, " The goal of these recommendations is to make people with diabetes and health care providers aware of beneficial nutrition interventions. " " This requires the use of the best available scientific evidence while taking into account treatment goals, strategies to attain such goals, and changes individuals with diabetes are willing and able to make. Achieving nutrition-related goals requires a coordinated team effort that includes the person with diabetes and involves him or her in the decision-making process. " In addition to listing major nutritional recommendations and interventions for diabetes, the updated position statement stresses the importance of monitoring metabolic parameters, including glucose and glycated hemoglobin levels, lipids, blood pressure, body weight, and renal function, during therapy. Such monitoring will help evaluate the need for changes in MNT and thereby optimize outcomes. The authors note that many aspects of MNT require additional research. Some of the specific recommendations include the following: list of 18 items . Individuals with prediabetes or diabetes should receive individualized MNT, preferably administered by a registered dietitian knowledgeable about the components of diabetes MNT (. . Nutrition counseling should be tailored to the personal needs of the individual with prediabetes or diabetes and his or her willingness and ability to make changes (E). . Modest weight loss in overweight and obese insulin-resistant individuals has been shown to improve insulin resistance and is therefore recommended for all such individuals who have or are at risk for diabetes (A). . In the short-term (up to 1 year), either low-carbohydrate or low-fat, energy-restricted diets may be effective for weight loss (A). . Patients receiving low-carbohydrate diets should undergo monitoring of lipid profiles, renal function, and protein intake (in patients with nephropathy), and have adjustment of hypoglycemic therapy as needed (E). . Physical activity and behavior modification aid in weight loss and are most helpful in maintaining weight loss (. . When combined with lifestyle modification, weight loss medications may help achieve a 5% to 10% weight loss and may be considered for overweight and obese individuals with type 2 diabetes (. . For some patients with type 2 diabetes and a body mass index of 35 kg/m2 or more, bariatric surgery can markedly improve glycemia (. . Primary prevention for individuals at high risk of developing type 2 diabetes should include structured programs targeting lifestyle changes, with dietary strategies of decreasing energy and dietary fat intakes. Goals should include moderate weight loss (7% body weight), regular physical activity (150 minutes/week) (A), dietary fiber intake of 14 g/1000 kcal, and whole grains comprising half of total grain intake (. . Intake of low-glycemic index foods that are rich in fiber and other vital nutrients should be encouraged (E), both for the general population and for those with diabetes. . Data do not support recommending alcohol consumption to individuals at risk for diabetes (. . Secondary prevention, or controlling diabetes, should include a healthy dietary pattern emphasizing carbohydrate from fruits, vegetables, whole grains, legumes, and low-fat milk (. . A key strategy for achieving glycemic control is to monitor carbohydrate by counting, exchanges, or experienced-based estimation (A). Use of glycemic index and load may be modestly beneficial vs considering only total carbohydrate (. . Sucrose-containing foods should be limited but can be substituted for other carbohydrates or covered with insulin or other glucose-lowering medications (A). Glucose alcohols and nonnutritive sweeteners are safe within daily US Food and Drug Administration intake levels (A). . Saturated fat should be limited to less than 7% of total energy (A), and trans fat should be minimized (E). In individuals with diabetes, dietary cholesterol should not exceed 200 mg/day (E). . At least 2 servings of fish per week (except for commercially fried fish) are recommended for n-3 polyunsaturated fatty acids (. . Protein should not be used to treat acute or prevent nighttime hypoglycemia (A). High-protein diets are not recommended for weight loss (E). . If adults with diabetes choose to use alcohol, intake should be restricted to 1 drink per day or less for women and 2 drinks per day or less for men (E) and consumed with food (E). list end Practice Pearls list of 2 items . Previous research has suggested that MNT can reduce glycated hemoglobin levels by approximately 1% for patients with type 1 diabetes and 1% to 2% for patients with type 2 diabetes. . The current guidelines do not recommend low-glycemic index or high-protein diets for the routine treatment of patients with diabetes. Moreover, most patients with diabetes should not routinely receive supplements or vitamins. list end The ADA has issued practice guidelines for screening, diagnostic, and treatment interventions that are known or believed to improve health outcomes of patients with diabetes. Each recommendation is graded by the ADA as A, B, C, or E to indicate the level of supporting evidence. Diabetes Care. 2008;31(Suppl 1):S61-S78. Article Options Print Print Send to Friend Send to friend This article is part of the following Newsletter This article is also part of the following Category See Diabetes In Control latest newsletter visit our home page. Search Diabetes In Control table with 2 columns and 2 rows Article Title: Article Description: table end Search Browse our other news categories below. A. Lee Dellon, MD | Beverly Price | Birgitta I. Rice, MS | Did You Know | Dr. Bernstein | Dr. Jakes, Jr. | Dr. Varon, DDS | Dr. Fred Pescatore | Dr. Walter Willett | Education | S. Freedland | Evan D. Rosen | Facts | Features | Ginger Kanzer- | Items for the Week | , MD | ph M. Caporusso | a Sandstedt | Plunkett | Leonard Lipson, M.A. | Lester A. Packer | Diane | New Products | Newsflash | Chous, M.A., OD | Philip A. Wood PhD | R. | Sheri R. Colberg PhD | Sherri Shafer | Steve Pohlit | Studies | Test Your Knowledge | Theresa L. Garnero | Tools | Vickie R. Driver | M. Volpone | Looking for a particular Newsletter Issue? Click Here Special Offers aserver/adview Free Newsletter Not Subscribed? Get the FREE Diabetes In Control Newsletter today. Click Here Special Offers aserver/adview New Product Visit our New Products Section Special Offers aserver/adview Free CE Available CE Programs On Diabetes Available Special Offers aserver/adview Jump To: Home | Advertising | All News Categories | Classifieds | Downloads | Education | Features | Feedback | Items of the Week | Links | Most Recent Additions | New Products | NewsFeed | Past Newsletters | Recommend Us | Search | Studies | Subscribe | Test Your Knowledge | This Week's Newsletter | Tools For Your Practice | Writers Archives | Go Way Back Privacy / About DIC / Advertising With Us / Contact DIC Flash movie start Special Offers http://www.diabetesincontrol.com/aserver/adclick.php?n=aa2c37b8 Tools Visit our Tools for your Practice Section Special Offers http://www.diabetesincontrol.com/aserver/adclick.php?n=a6afe5dc Test Your Knowledge View our Test Your Knowledge Section This article is part of the following Newsletter , and this Category 2008 ADA Guidelines for Medical Nutrition Therapy The American Diabetes Association (ADA) has updated its guidelines regarding medical nutrition therapy (MNT), including the use of low-carbohydrate diets to prevent diabetes, manage existing diabetes, and prevent or slow the rate of development of diabetes complications. The revised position statement, which is published in the January issue of Diabetes Care , updates those from 2002 and 2004, presenting evidence-based data published since 2000 and grading of recommendations according to the level of evidence available, based on the ADA evidence-grading system. P. Bantle, and colleagues from the ADA.write, " The goal of these recommendations is to make people with diabetes and health care providers aware of beneficial nutrition interventions. " " This requires the use of the best available scientific evidence while taking into account treatment goals, strategies to attain such goals, and changes individuals with diabetes are willing and able to make. Achieving nutrition-related goals requires a coordinated team effort that includes the person with diabetes and involves him or her in the decision-making process. " In addition to listing major nutritional recommendations and interventions for diabetes, the updated position statement stresses the importance of monitoring metabolic parameters, including glucose and glycated hemoglobin levels, lipids, blood pressure, body weight, and renal function, during therapy. Such monitoring will help evaluate the need for changes in MNT and thereby optimize outcomes. The authors note that many aspects of MNT require additional research. Some of the specific recommendations include the following: Individuals with prediabetes or diabetes should receive individualized MNT, preferably administered by a registered dietitian knowledgeable about the components of diabetes MNT (. Nutrition counseling should be tailored to the personal needs of the individual with prediabetes or diabetes and his or her willingness and ability to make changes (E). Modest weight loss in overweight and obese insulin-resistant individuals has been shown to improve insulin resistance and is therefore recommended for all such individuals who have or are at risk for diabetes (A). In the short-term (up to 1 year), either low-carbohydrate or low-fat, energy-restricted diets may be effective for weight loss (A). Patients receiving low-carbohydrate diets should undergo monitoring of lipid profiles, renal function, and protein intake (in patients with nephropathy), and have adjustment of hypoglycemic therapy as needed (E). Physical activity and behavior modification aid in weight loss and are most helpful in maintaining weight loss (. When combined with lifestyle modification, weight loss medications may help achieve a 5% to 10% weight loss and may be considered for overweight and obese individuals with type 2 diabetes (. For some patients with type 2 diabetes and a body mass index of 35 kg/m2 or more, bariatric surgery can markedly improve glycemia (. Primary prevention for individuals at high risk of developing type 2 diabetes should include structured programs targeting lifestyle changes, with dietary strategies of decreasing energy and dietary fat intakes. Goals should include moderate weight loss (7% body weight), regular physical activity (150 minutes/week) (A), dietary fiber intake of 14 g/1000 kcal, and whole grains comprising half of total grain intake (. Intake of low-glycemic index foods that are rich in fiber and other vital nutrients should be encouraged (E), both for the general population and for those with diabetes. Data do not support recommending alcohol consumption to individuals at risk for diabetes (. Secondary prevention, or controlling diabetes, should include a healthy dietary pattern emphasizing carbohydrate from fruits, vegetables, whole grains, legumes, and low-fat milk (. A key strategy for achieving glycemic control is to monitor carbohydrate by counting, exchanges, or experienced-based estimation (A). Use of glycemic index and load may be modestly beneficial vs considering only total carbohydrate (. Sucrose-containing foods should be limited but can be substituted for other carbohydrates or covered with insulin or other glucose-lowering medications (A). Glucose alcohols and nonnutritive sweeteners are safe within daily US Food and Drug Administration intake levels (A). Saturated fat should be limited to less than 7% of total energy (A), and trans fat should be minimized (E). In individuals with diabetes, dietary cholesterol should not exceed 200 mg/day (E). At least 2 servings of fish per week (except for commercially fried fish) are recommended for n-3 polyunsaturated fatty acids (. Protein should not be used to treat acute or prevent nighttime hypoglycemia (A). High-protein diets are not recommended for weight loss (E). If adults with diabetes choose to use alcohol, intake should be restricted to 1 drink per day or less for women and 2 drinks per day or less for men (E) and consumed with food (E). Practice Pearls Previous research has suggested that MNT can reduce glycated hemoglobin levels by approximately 1% for patients with type 1 diabetes and 1% to 2% for patients with type 2 diabetes. The current guidelines do not recommend low-glycemic index or high-protein diets for the routine treatment of patients with diabetes. Moreover, most patients with diabetes should not routinely receive supplements or vitamins. The ADA has issued practice guidelines for screening, diagnostic, and treatment interventions that are known or believed to improve health outcomes of patients with diabetes. Each recommendation is graded by the ADA as A, B, C, or E to indicate the level of supporting evidence. Diabetes Care. 2008;31(Suppl 1):S61-S78. See Diabetes In Control latest newsletter visit our Search Diabetes In Control Browse our other news categories below. | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | Special Offers http://www.diabetesincontrol.com/aserver/adclick.php?n=a929c42d Free Newsletter Not Subscribed? Get the FREE Diabetes In Control Newsletter today. Click Here / / / online clinical conference present global diabetes View over 200 multimedia lectures for FREE CME by the finest teachers in diabetes Enjoy the benefits of attending a live diabetes clinical conference without leaving your home or office FREE CME for time spent talking with your peers online + = An interdisciplinary online conference where the entire diabetes management team networks together. Flash movie end Copyright @ 1999-2006 Diabetes In Control, Inc.. All rights reserved. Quote Link to comment Share on other sites More sharing options...
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