Guest guest Posted August 21, 2002 Report Share Posted August 21, 2002 Writing again, having trouble with my O.E. editing, Now, I take Metforman but not the other mentioned drug: Does this mean that I'm out of danger? Ken B scarey article read more... This article is part of the following Newsletter , and this Category Combo of Diabetes Drugs Increases Mortality Combination treatment for type 2 diabetes using two classes of drugs -- metformin and sulfonylureas -- may increase the risk of hospitalization for cardiovascular disease and mortality, according to a new report. Researchers came to this conclusion after an analysis of pooled data from nine large observational studies. Senior investigator Dr. Vivian A. Fonseca stated that,? " The paper highlights a real dilemma we have today in diabetes treatment. " " We have drugs that lower glucose but we seem to run into problems over time with improving outcomes -- particularly cardiovascular outcomes. " " A big question, " he added, " is whether it is due to the disease or the drugs increasing cardiovascular risk. " To help answer that question, Fonseca, and colleagues performed a review of data from more than 101,000 study participants, about one quarter of whom received combination therapy with metformin and sulfonylurea. The other patients were treated with one of these agents or diet therapy. In the combination group, the risk of mortality from any cause was increased by 19 percent and by 29 percent for cardiovascular mortality. There were no statistically significant differences, however, when compared with the mortality rates in the other groups. However, the combined end-point of death or hospitalization due to cardiovascular disease was increased by 43 percent in the group on combination therapy, which was significantly greater than in the other groups. " So it appears, " continued Fonseca, " that there is some increased risk with this combination that is the most widely used diabetes treatment of two drugs that are cheap and generic. " Our findings, he concluded, " clearly demonstrate that further studies are needed not only to assess the association of combination therapy of metformin and sulfonylurea with all-cause and/or cardiovascular mortality, but also to understand the potential underlying mechanism of its effects. " Diabetes Care, August 2008 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 21, 2002 Report Share Posted August 21, 2002 Writing again, having trouble with my O.E. editing, Now, I take Metforman but not the other mentioned drug: Does this mean that I'm out of danger? Ken B scarey article read more... This article is part of the following Newsletter , and this Category Combo of Diabetes Drugs Increases Mortality Combination treatment for type 2 diabetes using two classes of drugs -- metformin and sulfonylureas -- may increase the risk of hospitalization for cardiovascular disease and mortality, according to a new report. Researchers came to this conclusion after an analysis of pooled data from nine large observational studies. Senior investigator Dr. Vivian A. Fonseca stated that,? " The paper highlights a real dilemma we have today in diabetes treatment. " " We have drugs that lower glucose but we seem to run into problems over time with improving outcomes -- particularly cardiovascular outcomes. " " A big question, " he added, " is whether it is due to the disease or the drugs increasing cardiovascular risk. " To help answer that question, Fonseca, and colleagues performed a review of data from more than 101,000 study participants, about one quarter of whom received combination therapy with metformin and sulfonylurea. The other patients were treated with one of these agents or diet therapy. In the combination group, the risk of mortality from any cause was increased by 19 percent and by 29 percent for cardiovascular mortality. There were no statistically significant differences, however, when compared with the mortality rates in the other groups. However, the combined end-point of death or hospitalization due to cardiovascular disease was increased by 43 percent in the group on combination therapy, which was significantly greater than in the other groups. " So it appears, " continued Fonseca, " that there is some increased risk with this combination that is the most widely used diabetes treatment of two drugs that are cheap and generic. " Our findings, he concluded, " clearly demonstrate that further studies are needed not only to assess the association of combination therapy of metformin and sulfonylurea with all-cause and/or cardiovascular mortality, but also to understand the potential underlying mechanism of its effects. " Diabetes Care, August 2008 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 20, 2008 Report Share Posted August 20, 2008 Wow, this is scary. I take Metformin and Glyburide. Is Glyburide another name for sulfonylurea? Becky _____ From: blind-diabetics [mailto:blind-diabetics ] On Behalf Of LaFrance-Wolf Sent: Wednesday, August 20, 2008 12:43 PM To: Blind-DiabeticsYahoogroups (DOT) Com; Acb-DiabeticsAcb (DOT) Org; Doc Mahaber Dr. (Doc Mahaber Dr.); diabetesworld Subject: scarey article read more... This article is part of the following Newsletter , and this Category Combo of Diabetes Drugs Increases Mortality Combination treatment for type 2 diabetes using two classes of drugs -- metformin and sulfonylureas -- may increase the risk of hospitalization for cardiovascular disease and mortality, according to a new report. Researchers came to this conclusion after an analysis of pooled data from nine large observational studies. Senior investigator Dr. Vivian A. Fonseca stated that,? " The paper highlights a real dilemma we have today in diabetes treatment. " " We have drugs that lower glucose but we seem to run into problems over time with improving outcomes -- particularly cardiovascular outcomes. " " A big question, " he added, " is whether it is due to the disease or the drugs increasing cardiovascular risk. " To help answer that question, Fonseca, and colleagues performed a review of data from more than 101,000 study participants, about one quarter of whom received combination therapy with metformin and sulfonylurea. The other patients were treated with one of these agents or diet therapy. In the combination group, the risk of mortality from any cause was increased by 19 percent and by 29 percent for cardiovascular mortality. There were no statistically significant differences, however, when compared with the mortality rates in the other groups. However, the combined end-point of death or hospitalization due to cardiovascular disease was increased by 43 percent in the group on combination therapy, which was significantly greater than in the other groups. " So it appears, " continued Fonseca, " that there is some increased risk with this combination that is the most widely used diabetes treatment of two drugs that are cheap and generic. " Our findings, he concluded, " clearly demonstrate that further studies are needed not only to assess the association of combination therapy of metformin and sulfonylurea with all-cause and/or cardiovascular mortality, but also to understand the potential underlying mechanism of its effects. " Diabetes Care, August 2008 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 20, 2008 Report Share Posted August 20, 2008 Wow, this is scary. I take Metformin and Glyburide. Is Glyburide another name for sulfonylurea? Becky _____ From: blind-diabetics [mailto:blind-diabetics ] On Behalf Of LaFrance-Wolf Sent: Wednesday, August 20, 2008 12:43 PM To: Blind-DiabeticsYahoogroups (DOT) Com; Acb-DiabeticsAcb (DOT) Org; Doc Mahaber Dr. (Doc Mahaber Dr.); diabetesworld Subject: scarey article read more... This article is part of the following Newsletter , and this Category Combo of Diabetes Drugs Increases Mortality Combination treatment for type 2 diabetes using two classes of drugs -- metformin and sulfonylureas -- may increase the risk of hospitalization for cardiovascular disease and mortality, according to a new report. Researchers came to this conclusion after an analysis of pooled data from nine large observational studies. Senior investigator Dr. Vivian A. Fonseca stated that,? " The paper highlights a real dilemma we have today in diabetes treatment. " " We have drugs that lower glucose but we seem to run into problems over time with improving outcomes -- particularly cardiovascular outcomes. " " A big question, " he added, " is whether it is due to the disease or the drugs increasing cardiovascular risk. " To help answer that question, Fonseca, and colleagues performed a review of data from more than 101,000 study participants, about one quarter of whom received combination therapy with metformin and sulfonylurea. The other patients were treated with one of these agents or diet therapy. In the combination group, the risk of mortality from any cause was increased by 19 percent and by 29 percent for cardiovascular mortality. There were no statistically significant differences, however, when compared with the mortality rates in the other groups. However, the combined end-point of death or hospitalization due to cardiovascular disease was increased by 43 percent in the group on combination therapy, which was significantly greater than in the other groups. " So it appears, " continued Fonseca, " that there is some increased risk with this combination that is the most widely used diabetes treatment of two drugs that are cheap and generic. " Our findings, he concluded, " clearly demonstrate that further studies are needed not only to assess the association of combination therapy of metformin and sulfonylurea with all-cause and/or cardiovascular mortality, but also to understand the potential underlying mechanism of its effects. " Diabetes Care, August 2008 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 21, 2008 Report Share Posted August 21, 2008 Here are the drugs taht apply: There are many sulfonylurea pills available. Four, known as " first-generation " drugs, have been in use for many years. Three, called " second-generation " drugs, have been developed more recently. They are sometimes stronger than first-generation drugs, but mainly have fewer side effects. Each type of pill is sold under two names: one is the generic name as listed by the US Food and Drug Administration; the other is the brand name given by the manufacturer. Some pills are available as lower-priced generics, others are only available as the branded version. They are: First-Generation Agents: Generic Name: acetohexamide Brand Name: Dymelor Generic Name: chlorpropamide Brand Name: Diabinese Generic Name: tolazamide Brand Name: Tolinase Generic Name: tolbutamide Brand Name: Orinase Second-Generation Agents: Generic Name: glimepiride Brand Name: Amaryl Generic Name: glipizide Brand Names: Glucotrol, Glucotrol XL Generic Name: glyburide Brand Names: DiaBeta, Micronase, Glynase Combination Agents: Combination of glyburide plus metformin Brand Name: GlucoVance Combination of glipizide plus metformin Brand name: Metaglip Combination of rosiglitazone plus metformin Brand name: Avandamet Combination of rosiglitazone plus Amaryl Brand name: Avandaryl _____ From: blind-diabetics [mailto:blind-diabetics ] On Behalf Of Kenbu Sent: Tuesday, August 20, 2002 10:46 PM To: blind-diabetics Subject: Re: scarey article Writing again, having trouble with my O.E. editing, Now, I take Metforman but not the other mentioned drug: Does this mean that I'm out of danger? Ken B scarey article read more... This article is part of the following Newsletter , and this Category Combo of Diabetes Drugs Increases Mortality Combination treatment for type 2 diabetes using two classes of drugs -- metformin and sulfonylureas -- may increase the risk of hospitalization for cardiovascular disease and mortality, according to a new report. Researchers came to this conclusion after an analysis of pooled data from nine large observational studies. Senior investigator Dr. Vivian A. Fonseca stated that,? " The paper highlights a real dilemma we have today in diabetes treatment. " " We have drugs that lower glucose but we seem to run into problems over time with improving outcomes -- particularly cardiovascular outcomes. " " A big question, " he added, " is whether it is due to the disease or the drugs increasing cardiovascular risk. " To help answer that question, Fonseca, and colleagues performed a review of data from more than 101,000 study participants, about one quarter of whom received combination therapy with metformin and sulfonylurea. The other patients were treated with one of these agents or diet therapy. In the combination group, the risk of mortality from any cause was increased by 19 percent and by 29 percent for cardiovascular mortality. There were no statistically significant differences, however, when compared with the mortality rates in the other groups. However, the combined end-point of death or hospitalization due to cardiovascular disease was increased by 43 percent in the group on combination therapy, which was significantly greater than in the other groups. " So it appears, " continued Fonseca, " that there is some increased risk with this combination that is the most widely used diabetes treatment of two drugs that are cheap and generic. " Our findings, he concluded, " clearly demonstrate that further studies are needed not only to assess the association of combination therapy of metformin and sulfonylurea with all-cause and/or cardiovascular mortality, but also to understand the potential underlying mechanism of its effects. " Diabetes Care, August 2008 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 21, 2008 Report Share Posted August 21, 2008 Here are the drugs taht apply: There are many sulfonylurea pills available. Four, known as " first-generation " drugs, have been in use for many years. Three, called " second-generation " drugs, have been developed more recently. They are sometimes stronger than first-generation drugs, but mainly have fewer side effects. Each type of pill is sold under two names: one is the generic name as listed by the US Food and Drug Administration; the other is the brand name given by the manufacturer. Some pills are available as lower-priced generics, others are only available as the branded version. They are: First-Generation Agents: Generic Name: acetohexamide Brand Name: Dymelor Generic Name: chlorpropamide Brand Name: Diabinese Generic Name: tolazamide Brand Name: Tolinase Generic Name: tolbutamide Brand Name: Orinase Second-Generation Agents: Generic Name: glimepiride Brand Name: Amaryl Generic Name: glipizide Brand Names: Glucotrol, Glucotrol XL Generic Name: glyburide Brand Names: DiaBeta, Micronase, Glynase Combination Agents: Combination of glyburide plus metformin Brand Name: GlucoVance Combination of glipizide plus metformin Brand name: Metaglip Combination of rosiglitazone plus metformin Brand name: Avandamet Combination of rosiglitazone plus Amaryl Brand name: Avandaryl _____ From: blind-diabetics [mailto:blind-diabetics ] On Behalf Of Kenbu Sent: Tuesday, August 20, 2002 10:46 PM To: blind-diabetics Subject: Re: scarey article Writing again, having trouble with my O.E. editing, Now, I take Metforman but not the other mentioned drug: Does this mean that I'm out of danger? Ken B scarey article read more... This article is part of the following Newsletter , and this Category Combo of Diabetes Drugs Increases Mortality Combination treatment for type 2 diabetes using two classes of drugs -- metformin and sulfonylureas -- may increase the risk of hospitalization for cardiovascular disease and mortality, according to a new report. Researchers came to this conclusion after an analysis of pooled data from nine large observational studies. Senior investigator Dr. Vivian A. Fonseca stated that,? " The paper highlights a real dilemma we have today in diabetes treatment. " " We have drugs that lower glucose but we seem to run into problems over time with improving outcomes -- particularly cardiovascular outcomes. " " A big question, " he added, " is whether it is due to the disease or the drugs increasing cardiovascular risk. " To help answer that question, Fonseca, and colleagues performed a review of data from more than 101,000 study participants, about one quarter of whom received combination therapy with metformin and sulfonylurea. The other patients were treated with one of these agents or diet therapy. In the combination group, the risk of mortality from any cause was increased by 19 percent and by 29 percent for cardiovascular mortality. There were no statistically significant differences, however, when compared with the mortality rates in the other groups. However, the combined end-point of death or hospitalization due to cardiovascular disease was increased by 43 percent in the group on combination therapy, which was significantly greater than in the other groups. " So it appears, " continued Fonseca, " that there is some increased risk with this combination that is the most widely used diabetes treatment of two drugs that are cheap and generic. " Our findings, he concluded, " clearly demonstrate that further studies are needed not only to assess the association of combination therapy of metformin and sulfonylurea with all-cause and/or cardiovascular mortality, but also to understand the potential underlying mechanism of its effects. " Diabetes Care, August 2008 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 21, 2008 Report Share Posted August 21, 2008 Thanks Yolanda, Good list to take to the doc! Re: scarey article Writing again, having trouble with my O.E. editing, Now, I take Metforman but not the other mentioned drug: Does this mean that I'm out of danger? Ken B scarey article read more... This article is part of the following Newsletter , and this Category Combo of Diabetes Drugs Increases Mortality Combination treatment for type 2 diabetes using two classes of drugs -- metformin and sulfonylureas -- may increase the risk of hospitalization for cardiovascular disease and mortality, according to a new report. Researchers came to this conclusion after an analysis of pooled data from nine large observational studies. Senior investigator Dr. Vivian A. Fonseca stated that,? " The paper highlights a real dilemma we have today in diabetes treatment. " " We have drugs that lower glucose but we seem to run into problems over time with improving outcomes -- particularly cardiovascular outcomes. " " A big question, " he added, " is whether it is due to the disease or the drugs increasing cardiovascular risk. " To help answer that question, Fonseca, and colleagues performed a review of data from more than 101,000 study participants, about one quarter of whom received combination therapy with metformin and sulfonylurea. The other patients were treated with one of these agents or diet therapy. In the combination group, the risk of mortality from any cause was increased by 19 percent and by 29 percent for cardiovascular mortality. There were no statistically significant differences, however, when compared with the mortality rates in the other groups. However, the combined end-point of death or hospitalization due to cardiovascular disease was increased by 43 percent in the group on combination therapy, which was significantly greater than in the other groups. " So it appears, " continued Fonseca, " that there is some increased risk with this combination that is the most widely used diabetes treatment of two drugs that are cheap and generic. " Our findings, he concluded, " clearly demonstrate that further studies are needed not only to assess the association of combination therapy of metformin and sulfonylurea with all-cause and/or cardiovascular mortality, but also to understand the potential underlying mechanism of its effects. " Diabetes Care, August 2008 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 21, 2008 Report Share Posted August 21, 2008 The study suggests that this happens only when metformen is combined wit sulfs. Re: scarey article Writing again, having trouble with my O.E. editing, Now, I take Metforman but not the other mentioned drug: Does this mean that I'm out of danger? Ken B scarey article read more... This article is part of the following Newsletter , and this Category Combo of Diabetes Drugs Increases Mortality Combination treatment for type 2 diabetes using two classes of drugs -- metformin and sulfonylureas -- may increase the risk of hospitalization for cardiovascular disease and mortality, according to a new report. Researchers came to this conclusion after an analysis of pooled data from nine large observational studies. Senior investigator Dr. Vivian A. Fonseca stated that,? " The paper highlights a real dilemma we have today in diabetes treatment. " " We have drugs that lower glucose but we seem to run into problems over time with improving outcomes -- particularly cardiovascular outcomes. " " A big question, " he added, " is whether it is due to the disease or the drugs increasing cardiovascular risk. " To help answer that question, Fonseca, and colleagues performed a review of data from more than 101,000 study participants, about one quarter of whom received combination therapy with metformin and sulfonylurea. The other patients were treated with one of these agents or diet therapy. In the combination group, the risk of mortality from any cause was increased by 19 percent and by 29 percent for cardiovascular mortality. There were no statistically significant differences, however, when compared with the mortality rates in the other groups. However, the combined end-point of death or hospitalization due to cardiovascular disease was increased by 43 percent in the group on combination therapy, which was significantly greater than in the other groups. " So it appears, " continued Fonseca, " that there is some increased risk with this combination that is the most widely used diabetes treatment of two drugs that are cheap and generic. " Our findings, he concluded, " clearly demonstrate that further studies are needed not only to assess the association of combination therapy of metformin and sulfonylurea with all-cause and/or cardiovascular mortality, but also to understand the potential underlying mechanism of its effects. " Diabetes Care, August 2008 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 21, 2008 Report Share Posted August 21, 2008 Thanks very much for doing the research. This is helpful. I seem to be taking one of the dangerous combinations so might talk to my doctor about this. Becky No virus found in this incoming message. Checked by AVG - http://www.avg.com Version: 8.0.138 / Virus Database: 270.6.6/1624 - Release Date: 8/20/2008 7:11 PM Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 21, 2008 Report Share Posted August 21, 2008 Thanks very much for doing the research. This is helpful. I seem to be taking one of the dangerous combinations so might talk to my doctor about this. Becky No virus found in this incoming message. Checked by AVG - http://www.avg.com Version: 8.0.138 / Virus Database: 270.6.6/1624 - Release Date: 8/20/2008 7:11 PM Quote Link to comment Share on other sites More sharing options...
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