cancer drugs seem to stop type 1 diabetes

November 27, 2008

Two Cancer Drugs Show Promise For Preventing and Reversing Type 1 Diabetes

Researchers at the University of California, San Francisco have reported

that two common cancer drugs have been used to block and reverse type 1

diabetes.

" The findings suggest that kinase inhibitors - successfully used in cancer -

may provide an important new therapeutic approach for treatment of new onset

type 1 diabetes and potentially other autoimmune disorders, " said JDRF

Director of Immunology Teodora Staeva, Ph.D.

The drugs - Imatinib and Sunitnib, sold as Gleevec and Sutent, respectively

- are used to treat cancer by blocking tyrosine kinases, an enzyme that

modify

cells' signaling proteins through a simple biochemical change. Kinases

trigger cell growth, and it is widely believed that tyrosine kinases are a

contributing

factor to autoimmune diseases and cancer. The researchers hypothesized that

tyrosine kinases may also serve as a trigger to the body's attack on the

immune

system.

" There are very few drugs to treat type 1 diabetes, especially after disease

onset, so this benefit, with a drug already proven to be safe and effective

in cancer patients, is very promising, " Bluestone of the University

of California, San Francisco, said in a statement.

" The fact that the treated mice maintained normal blood glucose levels for

some time after the drug treatment was stopped suggests that imatinib and

sunitinib

may be 'reprogramming' their immune systems in a permanent way, " said

Bluestone.

Type-1 diabetes affects an estimated 5 to 10 percent of the 20 million

Americans with diabetes. Also called juvenile diabetes, it has different

causes

from the more common type-2 diabetes that is linked with obesity, poor diet

and a lack of exercise. Type 1 diabetes is an autoimmune disease caused by

the destruction of insulin-producing cells in the pancreas.

Both Gleevec and Sutent inhibit tyrosine kinases, enzymes that are needed

for cell communication and growth and are linked with inflammation and

immunity.

Bluestone and colleagues wondered if these drugs could block some of the

same tyrosine kinases involved in the development of type 1 diabetes.

They tested the drugs in mice predisposed to type 1 diabetes and found that

the drugs kept the mice from developing diabetes.

They also tested them in mice with the disease and showed the drugs put the

disease in remission in 80 percent of the animals after only eight to 10

weeks

of treatment.

They said the drugs appear to block receptors of a tyrosine kinase not known

to be involved in diabetes. This enzyme, known as platelet-derived growth

factor

receptor, or PDGFR, regulates cell growth and division, and also plays a key

role in inflammation.

" This study opens up a new area of research in the field of type 1 diabetes,

and importantly, opens up exciting opportunities for developing new

therapies

to treat this disease and other autoimmune diseases, " Dr. Arthur Weiss of

University of California, San Francisco, who worked on the research, said in

a statement.

The JDRF-funded study,was led by Bluestone, Ph.D., director of the

Diabetes Center at UCSF and an expert in the field of autoimmunity.

The Proceedings of the National Academy of Sciences, Nov, 2008

=============================

Steps to Health Walking Program

The only program that is in use with over 200,000 patients. Reduce your

blood sugars for less then 25 dollars and you don't have to swallow

anything. $24.95

with discounts for 2 or more...

http://www.rx4betterhealth.com/ccp51/cgi-bin/cp-app.cgi?pg=prod & ref=sthp & cat

=sth & catstr=HOME:sth

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This article originally posted November 25, 2008 and appeared in

Issue 444

Past five issues:

Issue 444 |

Issue 443 |

Issue 442 |

Issue 441 |

Have a comment?

Post it here.

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Click Here!

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This article originally posted

November 25, 2008

and appeared in

Issue 444

Two Cancer Drugs Show Promise For Preventing and Reversing Type 1 Diabetes

Researchers at the University of California, San Francisco have reported

that two common cancer drugs have been used to block and reverse type 1

diabetes.

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This article originally posted

November 25, 2008

and appeared in

Issue 444

Two Cancer Drugs Show Promise For Preventing and Reversing Type 1 Diabetes

Researchers at the University of California, San Francisco have reported

that two common cancer drugs have been used to block and reverse type 1

diabetes.

Diabetes In Control Sponsors

http://www.diabetesincontrol.com/aserver/adclick.php?n=a8e6d6c1

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November 27, 2008

I heard this podcast about three weeks ago and was thrilled at the prospect.

_____

From: blind-diabetics

[mailto:blind-diabetics ] On Behalf Of LaFrance-Wolf

Sent: Thursday, November 27, 2008 11:38 AM

To: Blind-DiabeticsYahoogroups (DOT) Com; Acb-DiabeticsAcb (DOT) Org;

diabetesworld ; Doc Mahaber Dr. (Doc Mahaber Dr.); sandra

(sandra); 'Rayanne Myers'

Subject: cancer drugs seem to stop type 1 diabetes

Two Cancer Drugs Show Promise For Preventing and Reversing Type 1 Diabetes

Researchers at the University of California, San Francisco have reported

that two common cancer drugs have been used to block and reverse type 1

diabetes.

" The findings suggest that kinase inhibitors - successfully used in cancer -

may provide an important new therapeutic approach for treatment of new onset

type 1 diabetes and potentially other autoimmune disorders, " said JDRF

Director of Immunology Teodora Staeva, Ph.D.

The drugs - Imatinib and Sunitnib, sold as Gleevec and Sutent, respectively

- are used to treat cancer by blocking tyrosine kinases, an enzyme that

modify

cells' signaling proteins through a simple biochemical change. Kinases

trigger cell growth, and it is widely believed that tyrosine kinases are a

contributing

factor to autoimmune diseases and cancer. The researchers hypothesized that

tyrosine kinases may also serve as a trigger to the body's attack on the

immune

system.

" There are very few drugs to treat type 1 diabetes, especially after disease

onset, so this benefit, with a drug already proven to be safe and effective

in cancer patients, is very promising, " Bluestone of the University

of California, San Francisco, said in a statement.

" The fact that the treated mice maintained normal blood glucose levels for

some time after the drug treatment was stopped suggests that imatinib and

sunitinib

may be 'reprogramming' their immune systems in a permanent way, " said

Bluestone.

Type-1 diabetes affects an estimated 5 to 10 percent of the 20 million

Americans with diabetes. Also called juvenile diabetes, it has different

causes

from the more common type-2 diabetes that is linked with obesity, poor diet

and a lack of exercise. Type 1 diabetes is an autoimmune disease caused by

the destruction of insulin-producing cells in the pancreas.

Both Gleevec and Sutent inhibit tyrosine kinases, enzymes that are needed

for cell communication and growth and are linked with inflammation and

immunity.

Bluestone and colleagues wondered if these drugs could block some of the

same tyrosine kinases involved in the development of type 1 diabetes.

They tested the drugs in mice predisposed to type 1 diabetes and found that

the drugs kept the mice from developing diabetes.

They also tested them in mice with the disease and showed the drugs put the

disease in remission in 80 percent of the animals after only eight to 10

weeks

of treatment.

They said the drugs appear to block receptors of a tyrosine kinase not known

to be involved in diabetes. This enzyme, known as platelet-derived growth

factor

receptor, or PDGFR, regulates cell growth and division, and also plays a key

role in inflammation.

" This study opens up a new area of research in the field of type 1 diabetes,

and importantly, opens up exciting opportunities for developing new

therapies

to treat this disease and other autoimmune diseases, " Dr. Arthur Weiss of

University of California, San Francisco, who worked on the research, said in

a statement.

The JDRF-funded study,was led by Bluestone, Ph.D., director of the

Diabetes Center at UCSF and an expert in the field of autoimmunity.

The Proceedings of the National Academy of Sciences, Nov, 2008

=============================

Steps to Health Walking Program

The only program that is in use with over 200,000 patients. Reduce your

blood sugars for less then 25 dollars and you don't have to swallow

anything. $24.95

with discounts for 2 or more...

http://www.rx4bette

<http://www.rx4betterhealth.com/ccp51/cgi-bin/cp-app.cgi?pg=prod & ref=sthp & ca

t> rhealth.com/ccp51/cgi-bin/cp-app.cgi?pg=prod & ref=sthp & cat

=sth & catstr=HOME:sth

Send to Friend

| Share |

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Category |

Home

This article originally posted November 25, 2008 and appeared in

Issue 444

Past five issues:

Issue 444 |

Issue 443 |

Issue 442 |

Issue 441 |

Have a comment?

Post it here.

Visit the NEW Diabetes In Control Blog.

Click Here!

There are no comments to this article at this time.

Be the first!

Top Ten Most Read Articles:

A Spoonful of Vinegar Helps the Sugar Go Down

Read: 40056 Times

5 Sample Meal Plans, from 1200 to 2200 calories, in English and Spanish

Read: 18835 Times

Diabetes 101

Read: 16058 Times

New Type 3 Diabetes Discovered

Read: 14845 Times

Oral Insulin Spray (Oral-lyn) for Type 1 and 2 Diabetes in Ecuador

Read: 14434 Times

It's not just another glargine LevemirR

Read: 11878 Times

The GlucoBand-New Non-Invasive Continuous Blood Glucose Monitor-

Read: 11653 Times

Chili Extract A Possible Cure for Diabetes

Read: 11159 Times

Weight Training and Diabetes

Read: 9599 Times

Drugs in Development

Read: 9395 Times

See more most read...

Browse by Feature Writer & Article Category

A. Lee Dellon, MD |

Beverly Price |

Birgitta I. Rice, MS |

Did You Know |

Dr. Bernstein |

Dr. Jakes, Jr. |

Dr. Varon, DDS |

Dr. Fred Pescatore |

Dr. Walter Willett |

Education |

S. Freedland |

Evan D. Rosen |

Facts |

Features |

Ginger Kanzer- |

Items for the Week |

, MD |

ph M. Caporusso |

a Sandstedt |

Plunkett |

Leonard Lipson, M.A. |

Lester A. Packer |

Diane |

New Products |

Newsflash |

Chous, M.A., OD |

Philip A. Wood PhD |

R. |

Sheri R. Colberg PhD |

Sherri Shafer |

Steve Pohlit |

Studies |

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This article originally posted

November 25, 2008

and appeared in

Issue 444

Two Cancer Drugs Show Promise For Preventing and Reversing Type 1 Diabetes

Researchers at the University of California, San Francisco have reported

that two common cancer drugs have been used to block and reverse type 1

diabetes.

Diabetes In Control Sponsors

http://www.diabetes

<http://www.diabetesincontrol.com/aserver/adclick.php?n=a8e6d6c1>

incontrol.com/aserver/adclick.php?n=a8e6d6c1

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This article originally posted

November 25, 2008

and appeared in

Issue 444

Two Cancer Drugs Show Promise For Preventing and Reversing Type 1 Diabetes

Researchers at the University of California, San Francisco have reported

that two common cancer drugs have been used to block and reverse type 1

diabetes.

Diabetes In Control Sponsors

http://www.diabetes

<http://www.diabetesincontrol.com/aserver/adclick.php?n=a8e6d6c1>

incontrol.com/aserver/adclick.php?n=a8e6d6c1

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November 27, 2008

I heard this podcast about three weeks ago and was thrilled at the prospect.

_____

From: blind-diabetics

[mailto:blind-diabetics ] On Behalf Of LaFrance-Wolf

Sent: Thursday, November 27, 2008 11:38 AM

To: Blind-DiabeticsYahoogroups (DOT) Com; Acb-DiabeticsAcb (DOT) Org;

diabetesworld ; Doc Mahaber Dr. (Doc Mahaber Dr.); sandra

(sandra); 'Rayanne Myers'

Subject: cancer drugs seem to stop type 1 diabetes

Two Cancer Drugs Show Promise For Preventing and Reversing Type 1 Diabetes

Researchers at the University of California, San Francisco have reported

that two common cancer drugs have been used to block and reverse type 1

diabetes.

" The findings suggest that kinase inhibitors - successfully used in cancer -

may provide an important new therapeutic approach for treatment of new onset

type 1 diabetes and potentially other autoimmune disorders, " said JDRF

Director of Immunology Teodora Staeva, Ph.D.

The drugs - Imatinib and Sunitnib, sold as Gleevec and Sutent, respectively

- are used to treat cancer by blocking tyrosine kinases, an enzyme that

modify

cells' signaling proteins through a simple biochemical change. Kinases

trigger cell growth, and it is widely believed that tyrosine kinases are a

contributing

factor to autoimmune diseases and cancer. The researchers hypothesized that

tyrosine kinases may also serve as a trigger to the body's attack on the

immune

system.

" There are very few drugs to treat type 1 diabetes, especially after disease

onset, so this benefit, with a drug already proven to be safe and effective

in cancer patients, is very promising, " Bluestone of the University

of California, San Francisco, said in a statement.

" The fact that the treated mice maintained normal blood glucose levels for

some time after the drug treatment was stopped suggests that imatinib and

sunitinib

may be 'reprogramming' their immune systems in a permanent way, " said

Bluestone.

Type-1 diabetes affects an estimated 5 to 10 percent of the 20 million

Americans with diabetes. Also called juvenile diabetes, it has different

causes

from the more common type-2 diabetes that is linked with obesity, poor diet

and a lack of exercise. Type 1 diabetes is an autoimmune disease caused by

the destruction of insulin-producing cells in the pancreas.

Both Gleevec and Sutent inhibit tyrosine kinases, enzymes that are needed

for cell communication and growth and are linked with inflammation and

immunity.

Bluestone and colleagues wondered if these drugs could block some of the

same tyrosine kinases involved in the development of type 1 diabetes.

They tested the drugs in mice predisposed to type 1 diabetes and found that

the drugs kept the mice from developing diabetes.

They also tested them in mice with the disease and showed the drugs put the

disease in remission in 80 percent of the animals after only eight to 10

weeks

of treatment.

They said the drugs appear to block receptors of a tyrosine kinase not known

to be involved in diabetes. This enzyme, known as platelet-derived growth

factor

receptor, or PDGFR, regulates cell growth and division, and also plays a key

role in inflammation.

" This study opens up a new area of research in the field of type 1 diabetes,

and importantly, opens up exciting opportunities for developing new

therapies

to treat this disease and other autoimmune diseases, " Dr. Arthur Weiss of

University of California, San Francisco, who worked on the research, said in

a statement.

The JDRF-funded study,was led by Bluestone, Ph.D., director of the

Diabetes Center at UCSF and an expert in the field of autoimmunity.

The Proceedings of the National Academy of Sciences, Nov, 2008

=============================

Steps to Health Walking Program

The only program that is in use with over 200,000 patients. Reduce your

blood sugars for less then 25 dollars and you don't have to swallow

anything. $24.95

with discounts for 2 or more...

http://www.rx4bette

<http://www.rx4betterhealth.com/ccp51/cgi-bin/cp-app.cgi?pg=prod & ref=sthp & ca

t> rhealth.com/ccp51/cgi-bin/cp-app.cgi?pg=prod & ref=sthp & cat

=sth & catstr=HOME:sth

Send to Friend

| Share |

Print |

Category |

Home

This article originally posted November 25, 2008 and appeared in

Issue 444

Past five issues:

Issue 444 |

Issue 443 |

Issue 442 |

Issue 441 |

Have a comment?

Post it here.

Visit the NEW Diabetes In Control Blog.

Click Here!

There are no comments to this article at this time.

Be the first!

Top Ten Most Read Articles:

A Spoonful of Vinegar Helps the Sugar Go Down

Read: 40056 Times

5 Sample Meal Plans, from 1200 to 2200 calories, in English and Spanish

Read: 18835 Times

Diabetes 101

Read: 16058 Times

New Type 3 Diabetes Discovered

Read: 14845 Times

Oral Insulin Spray (Oral-lyn) for Type 1 and 2 Diabetes in Ecuador

Read: 14434 Times

It's not just another glargine LevemirR

Read: 11878 Times

The GlucoBand-New Non-Invasive Continuous Blood Glucose Monitor-

Read: 11653 Times

Chili Extract A Possible Cure for Diabetes

Read: 11159 Times

Weight Training and Diabetes

Read: 9599 Times

Drugs in Development

Read: 9395 Times

See more most read...

Browse by Feature Writer & Article Category

A. Lee Dellon, MD |

Beverly Price |

Birgitta I. Rice, MS |

Did You Know |

Dr. Bernstein |

Dr. Jakes, Jr. |

Dr. Varon, DDS |

Dr. Fred Pescatore |

Dr. Walter Willett |

Education |

S. Freedland |

Evan D. Rosen |

Facts |

Features |

Ginger Kanzer- |

Items for the Week |

, MD |

ph M. Caporusso |

a Sandstedt |

Plunkett |

Leonard Lipson, M.A. |

Lester A. Packer |

Diane |

New Products |

Newsflash |

Chous, M.A., OD |

Philip A. Wood PhD |

R. |

Sheri R. Colberg PhD |

Sherri Shafer |

Steve Pohlit |

Studies |

Test Your Knowledge |

Theresa L. Garnero |

Tools |

Vickie R. Driver |

M. Volpone |

This Week's Blog |

Press Releases |

Search Articles On Diabetes In Control

Article Title:

and/or Description:

imageField

Diabetes In Control Sponsors

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This article originally posted

November 25, 2008

and appeared in

Issue 444

Two Cancer Drugs Show Promise For Preventing and Reversing Type 1 Diabetes

Researchers at the University of California, San Francisco have reported

that two common cancer drugs have been used to block and reverse type 1

diabetes.

Diabetes In Control Sponsors

http://www.diabetes

<http://www.diabetesincontrol.com/aserver/adclick.php?n=a8e6d6c1>

incontrol.com/aserver/adclick.php?n=a8e6d6c1

Flash movie end

Print This Week's Newsletter

Download This Week's Newsletter

Newsletter is in Adobe format

If you don't have Adobe Acrobat Reader, you can download it for Free

here.

Free CE Available

CE Programs On Diabetes Available

here

alltop

Flash movie start

http://www.diabetes

<http://www.diabetesincontrol.com/aserver/adclick.php?bannerid=67 & zoneid=1 & s

o> incontrol.com/aserver/adclick.php?bannerid=67 & zoneid=1 & so

urce= & dest=http%3A%2F%2Fwww.disetronic-usa.com%2Fdstrnc_us%2Frewrite%2Fgener

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This article originally posted

November 25, 2008

and appeared in

Issue 444

Two Cancer Drugs Show Promise For Preventing and Reversing Type 1 Diabetes

Researchers at the University of California, San Francisco have reported

that two common cancer drugs have been used to block and reverse type 1

diabetes.

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November 27, 2008

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Subject: cancer drugs seem to stop type 1 diabetes

Two Cancer Drugs Show Promise For Preventing and Reversing Type 1 Diabetes

Researchers at the University of California, San Francisco have reported

that two common cancer drugs have been used to block and reverse type 1

diabetes.

" The findings suggest that kinase inhibitors - successfully used in cancer -

may provide an important new therapeutic approach for treatment of new onset

type 1 diabetes and potentially other autoimmune disorders, " said JDRF

Director of Immunology Teodora Staeva, Ph.D.

The drugs - Imatinib and Sunitnib, sold as Gleevec and Sutent, respectively

- are used to treat cancer by blocking tyrosine kinases, an enzyme that

modify

cells' signaling proteins through a simple biochemical change. Kinases

trigger cell growth, and it is widely believed that tyrosine kinases are a

contributing

factor to autoimmune diseases and cancer. The researchers hypothesized that

tyrosine kinases may also serve as a trigger to the body's attack on the

immune

system.

" There are very few drugs to treat type 1 diabetes, especially after disease

onset, so this benefit, with a drug already proven to be safe and effective

in cancer patients, is very promising, " Bluestone of the University

of California, San Francisco, said in a statement.

" The fact that the treated mice maintained normal blood glucose levels for

some time after the drug treatment was stopped suggests that imatinib and

sunitinib

may be 'reprogramming' their immune systems in a permanent way, " said

Bluestone.

Type-1 diabetes affects an estimated 5 to 10 percent of the 20 million

Americans with diabetes. Also called juvenile diabetes, it has different

causes

from the more common type-2 diabetes that is linked with obesity, poor diet

and a lack of exercise. Type 1 diabetes is an autoimmune disease caused by

the destruction of insulin-producing cells in the pancreas.

Both Gleevec and Sutent inhibit tyrosine kinases, enzymes that are needed

for cell communication and growth and are linked with inflammation and

immunity.

Bluestone and colleagues wondered if these drugs could block some of the

same tyrosine kinases involved in the development of type 1 diabetes.

They tested the drugs in mice predisposed to type 1 diabetes and found that

the drugs kept the mice from developing diabetes.

They also tested them in mice with the disease and showed the drugs put the

disease in remission in 80 percent of the animals after only eight to 10

weeks

of treatment.

They said the drugs appear to block receptors of a tyrosine kinase not known

to be involved in diabetes. This enzyme, known as platelet-derived growth

factor

receptor, or PDGFR, regulates cell growth and division, and also plays a key

role in inflammation.

" This study opens up a new area of research in the field of type 1 diabetes,

and importantly, opens up exciting opportunities for developing new

therapies

to treat this disease and other autoimmune diseases, " Dr. Arthur Weiss of

University of California, San Francisco, who worked on the research, said in

a statement.

The JDRF-funded study,was led by Bluestone, Ph.D., director of the

Diabetes Center at UCSF and an expert in the field of autoimmunity.

The Proceedings of the National Academy of Sciences, Nov, 2008

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This article originally posted November 25, 2008 and appeared in

Issue 444

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This article originally posted

November 25, 2008

and appeared in

Issue 444

Two Cancer Drugs Show Promise For Preventing and Reversing Type 1 Diabetes

Researchers at the University of California, San Francisco have reported

that two common cancer drugs have been used to block and reverse type 1

diabetes.

Diabetes In Control Sponsors

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This article originally posted

November 25, 2008

and appeared in

Issue 444

Two Cancer Drugs Show Promise For Preventing and Reversing Type 1 Diabetes

Researchers at the University of California, San Francisco have reported

that two common cancer drugs have been used to block and reverse type 1

diabetes.

Diabetes In Control Sponsors

http://www.diabetes

<http://www.diabetesincontrol.com/aserver/adclick.php?n=a8e6d6c1>

incontrol.com/aserver/adclick.php?n=a8e6d6c1

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