Loss of Enzyme Reduces Neural Activity in Angelman Syndrome

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During the first few years of life, brain activity is " rewired " by external

stimuli . This tweaking of neuronal connections is critical to establish normal

neurological function, and is thought to go awry in a number of developmental

disorders that lead to mental retardation or other cognitive problems. The new

work suggests that Ube3A is a key regulator in this process, and ties the loss

of Ube3A to a specific change in synaptic function.

More: http://www.sciencedaily.com/releases/2010/03/100304121538.htm