Re: Re: RESEARCH - The influence of cigarette smoking on autoantibodies in SLE

[Guest guest]

Clora,

Hang in there, believe me it is the best gift you can give yourself. I

stopped Feb 28. 1991 after smoking for 20+ years.I will be pulling for ya

Heidi M

On Tue, Nov 11, 2008 at 5:55 PM, CLORA <clora4jesus@...> wrote:

> GRoup

>

> I am quitting November 20. I have cut down a lot. No smoking

> anymore nov 20. I was lighing up one right after the other. I am

> really ready to quit. Also Novermber 20 is smoke out day. and my

> 55th birthday. My birthday present to me is quiting smoking.

> Shirley looked up the no smoking day and said since I am quitting

> that day that is a present to me. lol.

>

> Clora

>

> ********************************************************

> >

> > ACR/AHRP 2008 Scientific Meeting

> >

> > Session: SLE: Clinical Aspects III

> > Tuesday, Oct 28, 2008, 9:00 AM - 6:00 PM

> >

> >

> > Presentation: 1736 - The Influence of Cigarette Smoking on

> > Autoantibodies in SLE

> >

> >

> > Author(s): F. Brandt, Schmitz, Melinda Drum, Tammy O.

> > Utset. University of Chicago, Chicago, IL

> >

> >

> > Abstract:

> >

> > Purpose: How cigarette smoking in SLE patients influences SLE

> > associated autoantibodies is largely unknown. Sparse data suggests

> > that smoking is correlated with anti-dsDNA. We evaluated the impact

> of

> > current smoking, ever smoking, and never smoking on SLE serologies.

> >

> > Methods: Ambulatory patients fulfilling ACR criteria for SLE were

> > enrolled in a clinical database during visits at the University of

> > Chicago Rheumatology Clinic. SLE medical history and demographic

> data

> > were obtained by standardized questionnaires. Smoking status was

> > defined as current, past, or never-smoker. Ever-smokers were defined

> > as either past or current smokers. Serologic data was obtained from

> > chart review. DsDNA, Sm, RNP, SSA and SSB assays (Inova Diagnostics)

> > were performed at the University of Chicago Laboratories in nearly

> all

> > cases. The enrollment anti-dsDNA titer was defined as the dsDNA

> titer

> > nearest to time of enrollment if performed within 6 months. Data was

> > entered into a Microsoft Access Database and analyzed using Stata

> > 10.0. Associations between smoking status (current/past/never and

> > ever/never) and autoantibodies were determined by using Fisher's

> exact

> > test, ANOVAs, t tests, Kruskal-Wallis rank tests and Wilcoxon rank

> sum

> > tests where appropriate.

> >

> > Results: 219 SLE subjects enrolled in the cross-sectional database.

> > 207 subjects had data on both smoking status and enrollment anti-

> dsDNA

> > available. Ever-positive status for anti-RNP, anti-, anti-SSA

> and

> > anti-SSB and smoking status was available in 138 to 164 patients.

> Mean

> > enrollment anti-dsDNA titer in never-smokers was higher compared to

> > ever-smokers (p = 0.007). While ever-positive anti-dsDNA did not

> vary

> > in ever-smokers relative to never-smokers, current non-smokers were

> > significantly more likely than current smokers to have had

> > ever-positive anti-dsDNA (p=.02). Additionally, the highest observed

> > past anti-dsDNA titer was significantly higher in never-smokers

> > compared to ever-smokers (p=0.04). Compared to ever-smokers,

> > never-smokers had a higher frequency positivity of anti-RNP

> (p=0.05),

> > anti-SSA (p=0.03) and a trend towards anti- (p=0.07). The value

> > of the highest observed anti-RNP (p=0.03) and anti-SSA (p=0.03) was

> > also higher in never-smokers. Interestingly, never-smokers had an

> > earlier mean age of SLE onset compared to ever-smokers of almost 5

> > years (p=0.003).

> >

> > Conclusion: In many diseases, including RA, smoking contributes to

> > disease and is not protective. However, a protective effect in

> > ulcerative colitis in terms of disease activity and age of onset has

> > been seen. Our data suggests that a history of smoking in SLE

> patients

> > is protective against the development as well as the titer of SLE

> > autoantibodies. In addition, current smokers appear protected

> against

> > the development of anti-dsDNA. As in ulcerative colitis, our data

> > suggests a history of smoking may also delay age of SLE onset.

> > Although smoking is harmful in many other respects in SLE, this data

> > suggests there may be a possible novel immunomodulatory effect on

> > disease that is worth further study.

> >

> >

> > http://www.abstractsonline.com/plan/start.aspx?mkey={5880E483-F47E-

> 4EFF-A557-2EF143592815}

> >

> >

> >

> > Not an MD

> >

>

>

>

[Guest guest]

Shirley;

Ok

Clora

 

From: nana2livi <s.p5315@...>

Subject: [ ] Re: RESEARCH - The influence of cigarette smoking on

autoantibodies in SLE

Date: Wednesday, November 12, 2008, 6:34 PM

Clora,

Shirley don't care. If she doesn't like it she can just not read!

Shirley

>

> Heidi and group;

>

> Thanks so much Heidi. Woo hoo Heidi you're a quitter. I will let

the

> group know 3 days after I start how I am doing. I do think the

first

> 3 days is the hardest. Unless Shirley don't want smoking

mentioned

> cause she is quiting the 20 also.

>

> I am already down to 1 pack a day. I was smoking 2 packs a day.

I

> just want a head start on quitting. I am so glad that everyone is

> rooting for us to quit. I can't wait to be an ex smoker.

>

> gentle hugs

> clora

>

[Guest guest]

NOT TO B MEAN OR ANYTHING BUT HOW DID SMOKING GET INVOLVE WITH OUR TOPIC RA????

THIS IS AN RA SUPPORT GROUP NOT AN SMOKING GROUP!!!!!!!!! THAT'S NOT VERY NICE

CLORA TO TELL SHIRLEY NOT TO READ THE POSTS THEN!!!!!!!!!! LET'S JUST STICK TO

THE TOPIC

RA!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!\

!!!!!! I APOLOGIZE FOR CLORA SHIRLEY. GOD BLESS, MELYNDA 11/13/08 10A.M.CDT

________________________________

From: Clora <clora4jesus@...>

Sent: Wednesday, November 12, 2008 11:18:13 PM

Subject: Re: [ ] Re: RESEARCH - The influence of cigarette smoking on

autoantibodies in SLE

Shirley;

Ok

Clora

 

From: nana2livi <s.p5315@...>

Subject: [ ] Re: RESEARCH - The influence of cigarette smoking on

autoantibodies in SLE

Date: Wednesday, November 12, 2008, 6:34 PM

Clora,

Shirley don't care. If she doesn't like it she can just not read!

Shirley

>

> Heidi and group;

>

> Thanks so much Heidi. Woo hoo Heidi you're a quitter. I will let

the

> group know 3 days after I start how I am doing. I do think the

first

> 3 days is the hardest. Unless Shirley don't want smoking

mentioned

> cause she is quiting the 20 also.

>

> I am already down to 1 pack a day. I was smoking 2 packs a day.

I

> just want a head start on quitting. I am so glad that everyone is

> rooting for us to quit. I can't wait to be an ex smoker.

>

> gentle hugs

> clora

>

     

[Guest guest]

I feel the emhasis is our health.

The common denominator is RA

Smoking affects RA.

If we can support each other into improving our health, that is something to be

proud of.

I, personally do not see how anyone is harmed.

Perhaps a sub group should be started for RA and smokers.

 

I am sorry you feel anger. God Bless. 

Raniolo

From: nana2livi <s.p5315 (DOT) com>

Subject: [ ] Re: RESEARCH - The influence of cigarette smoking on

autoantibodies in SLE

@gro ups.com

Date: Wednesday, November 12, 2008, 6:34 PM

Clora,

Shirley don't care. If she doesn't like it she can just not read!

Shirley

>

> Heidi and group;

>

> Thanks so much Heidi. Woo hoo Heidi you're a quitter. I will let

the

> group know 3 days after I start how I am doing. I do think the

first

> 3 days is the hardest. Unless Shirley don't want smoking

mentioned

> cause she is quiting the 20 also.

>

> I am already down to 1 pack a day. I was smoking 2 packs a day.

I

> just want a head start on quitting. I am so glad that everyone is

> rooting for us to quit. I can't wait to be an ex smoker.

>

> gentle hugs

> clora

>

     

[Guest guest]

catherine, i'm not ANGRY. i'm UPSET how some people can b RUDE to others.

there's no need for that!!!

yes the emphasis is our health(R.A.) SUFFERERS.. if people smoke that's their

business not ours. our's SUFFERING FROM R.A. NOT SMOKING!!!!!!!!!!!!!! THAT'S A

WHOLE DIFFERENT GROUP. once again i APOLOGIZE SHIRLEY. MELYNDA 11/13/08

10:20a.m.cdt

________________________________

From: CATHERINE RANIOLO <c.raniolo@...>

Sent: Thursday, November 13, 2008 10:10:24 AM

Subject: Re: [ ] Re: RESEARCH - The influence of cigarette smoking on

autoantibodies in SLE

I feel the emhasis is our health.

The common denominator is RA

Smoking affects RA.

If we can support each other into improving our health, that is something to be

proud of.

I, personally do not see how anyone is harmed.

Perhaps a sub group should be started for RA and smokers.

 

I am sorry you feel anger. God Bless. 

Raniolo

From: nana2livi <s.p5315 (DOT) com>

Subject: [ ] Re: RESEARCH - The influence of cigarette smoking on

autoantibodies in SLE

@gro ups.com

Date: Wednesday, November 12, 2008, 6:34 PM

Clora,

Shirley don't care. If she doesn't like it she can just not read!

Shirley

>

> Heidi and group;

>

> Thanks so much Heidi. Woo hoo Heidi you're a quitter. I will let

the

> group know 3 days after I start how I am doing. I do think the

first

> 3 days is the hardest.. Unless Shirley don't want smoking

mentioned

> cause she is quiting the 20 also.

>

> I am already down to 1 pack a day. I was smoking 2 packs a day.

I

> just want a head start on quitting. I am so glad that everyone is

> rooting for us to quit. I can't wait to be an ex smoker.

>

> gentle hugs

> clora

>

     

[Guest guest]

Melynda and group;

 

Melynda I apologize if smoking is a topic that is upsetting to you.  I only

wanted the support since smoking affects RA.  I didn't mean to make anyone to

feel bad.  Forgive me anyone whom may be upset by this topic. 

 

gentle hugs

Clora

 

From: nana2livi <s.p5315 (DOT) com>

Subject: [ ] Re: RESEARCH - The influence of cigarette smoking on

autoantibodies in SLE

@gro ups.com

Date: Wednesday, November 12, 2008, 6:34 PM

Clora,

Shirley don't care. If she doesn't like it she can just not read!

Shirley

>

> Heidi and group;

>

> Thanks so much Heidi. Woo hoo Heidi you're a quitter. I will let

the

> group know 3 days after I start how I am doing. I do think the

first

> 3 days is the hardest. Unless Shirley don't want smoking

mentioned

> cause she is quiting the 20 also.

>

> I am already down to 1 pack a day. I was smoking 2 packs a day.

I

> just want a head start on quitting. I am so glad that everyone is

> rooting for us to quit. I can't wait to be an ex smoker.

>

> gentle hugs

> clora

>

     

[Guest guest]

Melynda,

You just came in on the tail end of the conversation, so let me try to

explain. posted some articles on how smoking affects Ra. Clora and

Shirley decided to try to quit smoking, starting on I believe Nov. 20,

the big Smokeout Day.

Shirley and Clora were definitely not being rude to each other; neither

one has a rude bone in her body. They were joking around.

Sue

On Thursday, November 13, 2008, at 11:20 AM, Melynda Gamez wrote:

> catherine, i'm not ANGRY. i'm UPSET how some people can b RUDE to

> others. there's no need for that!!!

> yes the emphasis is our health(R.A.) SUFFERERS.. if people smoke

> that's their business not ours. our's SUFFERING FROM R.A. NOT

> SMOKING!!!!!!!!!!!!!! THAT'S A WHOLE DIFFERENT GROUP. once again i

> APOLOGIZE SHIRLEY. MELYNDA 11/13/08 10:20a.m.cdt