Re: RESEARCH - The influence of cigarette smoking on autoantibodies in SLE

[Guest guest]

GRoup

I am quitting November 20. I have cut down a lot. No smoking

anymore nov 20. I was lighing up one right after the other. I am

really ready to quit. Also Novermber 20 is smoke out day. and my

55th birthday. My birthday present to me is quiting smoking.

Shirley looked up the no smoking day and said since I am quitting

that day that is a present to me. lol.

Clora

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>

> ACR/AHRP 2008 Scientific Meeting

>

> Session: SLE: Clinical Aspects III

> Tuesday, Oct 28, 2008, 9:00 AM - 6:00 PM

>

>

> Presentation: 1736 - The Influence of Cigarette Smoking on

> Autoantibodies in SLE

>

>

> Author(s): F. Brandt, Schmitz, Melinda Drum, Tammy O.

> Utset. University of Chicago, Chicago, IL

>

>

> Abstract:

>

> Purpose: How cigarette smoking in SLE patients influences SLE

> associated autoantibodies is largely unknown. Sparse data suggests

> that smoking is correlated with anti-dsDNA. We evaluated the impact

of

> current smoking, ever smoking, and never smoking on SLE serologies.

>

> Methods: Ambulatory patients fulfilling ACR criteria for SLE were

> enrolled in a clinical database during visits at the University of

> Chicago Rheumatology Clinic. SLE medical history and demographic

data

> were obtained by standardized questionnaires. Smoking status was

> defined as current, past, or never-smoker. Ever-smokers were defined

> as either past or current smokers. Serologic data was obtained from

> chart review. DsDNA, Sm, RNP, SSA and SSB assays (Inova Diagnostics)

> were performed at the University of Chicago Laboratories in nearly

all

> cases. The enrollment anti-dsDNA titer was defined as the dsDNA

titer

> nearest to time of enrollment if performed within 6 months. Data was

> entered into a Microsoft Access Database and analyzed using Stata

> 10.0. Associations between smoking status (current/past/never and

> ever/never) and autoantibodies were determined by using Fisher's

exact

> test, ANOVAs, t tests, Kruskal-Wallis rank tests and Wilcoxon rank

sum

> tests where appropriate.

>

> Results: 219 SLE subjects enrolled in the cross-sectional database.

> 207 subjects had data on both smoking status and enrollment anti-

dsDNA

> available. Ever-positive status for anti-RNP, anti-, anti-SSA

and

> anti-SSB and smoking status was available in 138 to 164 patients.

Mean

> enrollment anti-dsDNA titer in never-smokers was higher compared to

> ever-smokers (p = 0.007). While ever-positive anti-dsDNA did not

vary

> in ever-smokers relative to never-smokers, current non-smokers were

> significantly more likely than current smokers to have had

> ever-positive anti-dsDNA (p=.02). Additionally, the highest observed

> past anti-dsDNA titer was significantly higher in never-smokers

> compared to ever-smokers (p=0.04). Compared to ever-smokers,

> never-smokers had a higher frequency positivity of anti-RNP

(p=0.05),

> anti-SSA (p=0.03) and a trend towards anti- (p=0.07). The value

> of the highest observed anti-RNP (p=0.03) and anti-SSA (p=0.03) was

> also higher in never-smokers. Interestingly, never-smokers had an

> earlier mean age of SLE onset compared to ever-smokers of almost 5

> years (p=0.003).

>

> Conclusion: In many diseases, including RA, smoking contributes to

> disease and is not protective. However, a protective effect in

> ulcerative colitis in terms of disease activity and age of onset has

> been seen. Our data suggests that a history of smoking in SLE

patients

> is protective against the development as well as the titer of SLE

> autoantibodies. In addition, current smokers appear protected

against

> the development of anti-dsDNA. As in ulcerative colitis, our data

> suggests a history of smoking may also delay age of SLE onset.

> Although smoking is harmful in many other respects in SLE, this data

> suggests there may be a possible novel immunomodulatory effect on

> disease that is worth further study.

>

>

> http://www.abstractsonline.com/plan/start.aspx?mkey={5880E483-F47E-

4EFF-A557-2EF143592815}

>

>

>

> Not an MD

>

[Guest guest]

Heidi and group;

Thanks so much Heidi. Woo hoo Heidi you're a quitter. I will let the

group know 3 days after I start how I am doing. I do think the first

3 days is the hardest. Unless Shirley don't want smoking mentioned

cause she is quiting the 20 also.

I am already down to 1 pack a day. I was smoking 2 packs a day. I

just want a head start on quitting. I am so glad that everyone is

rooting for us to quit. I can't wait to be an ex smoker.

gentle hugs

clora

*************************************************************

>

> Clora,

> Hang in there, believe me it is the best gift you can give

yourself. I

> stopped Feb 28. 1991 after smoking for 20+ years.I will be pulling

for ya

> Heidi M

>

[Guest guest]

Clora,

Shirley don't care. If she doesn't like it she can just not read!

Shirley

>

> Heidi and group;

>

> Thanks so much Heidi. Woo hoo Heidi you're a quitter. I will let

the

> group know 3 days after I start how I am doing. I do think the

first

> 3 days is the hardest. Unless Shirley don't want smoking

mentioned

> cause she is quiting the 20 also.

>

> I am already down to 1 pack a day. I was smoking 2 packs a day.

I

> just want a head start on quitting. I am so glad that everyone is

> rooting for us to quit. I can't wait to be an ex smoker.

>

> gentle hugs

> clora

>