RESEARCH - Regulation of BMD in morbidly obese women: a cross-sectional study in two cohorts before and after bypass surgery

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Obes Surg. 2008 Apr 29.

Regulation of Bone Mineral Density in Morbidly Obese Women: A

Cross-sectional Study in Two Cohorts Before and After Bypass Surgery.

Gómez JM, Vilarrasa N, Masdevall C, Pujol J, Solano E, Soler J, Elio

I, Gallart L, Vendrell J.

CIBERDEM, Endocrinology Service, Hospital Universitario de Bellvitge,

L'Hospitalet de Llobregat, Barcelona, Spain.

BACKGROUND: The mechanisms by which increased body weight influence

bone mass density (BMD) are still unknown. The aim of our study was to

analyze the relationship between anthropometric and body composition

variables, insulin growth factor-I (IGF-I), adiponectin and soluble

tumor necrosis factor-alpha receptors (sTNFR) 1 and 2 with BMD in two

cohorts of morbid obese patients, before and after bypass surgery.

METHODS: The first cohort included 25 women aged 48 +/- 7.6 years

studied before bypass surgery. The second included 41 women aged 46

+/- 9.2 years, 12 months after surgery. We studied anthropometric

variables obtained from whole body DEXA composition analysis. Serum

IGF-I, intact serum parathyroid hormone, 25-hydroxivitamin D(3),

plasma adiponectin concentrations, sTNFR1, sTNFR2 concentrations were

measured.

RESULTS: In the first cohort, the BMI was 44.5 +/- 3.6 kg/m(2),

parathyroid hormone, IGF-I, and adiponectin concentrations were lower,

and sTNFR1 concentrations were higher than in the second cohort. In

the multiple regression analysis, BMD remained significantly

associated with body fat percentage (beta -0.154, p = 0.01), lean mass

(beta 0.057, p = 0.016) and phosphate concentration (beta 0.225, p =

0.05). In the second cohort, BMI was 31 +/- 5.1 kg/m(2). In the

multiple regression analysis, BMD remained significantly associated

with lean mass (beta 0.006, p = 0.03).

CONCLUSION: The inverse correlation found between body fat and BMD in

the first cohort indicates morbid obesity increases the risk of

osteoporosis and we found a positive correlation with lean and fat

mass before bariatric surgery and with lean mass after bypass surgery.

PMID: 18443887

http://www.ncbi.nlm.nih.gov/pubmed/18443887

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