RESEARCH - Osteoporosis associated with the metabolic syndrome

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Clin Calcium. 2008 May;18(5):606-11.

[Osteoporosis associated with the metabolic syndrome][Article in Japanese]

Yamaguchi T.

Shimane University, Faculty of Medicine, Internal Medicine 1.

The metabolic syndrome is featured by the combination of obesity,

dyslipidemia, hyperglycemia, and hypertension. It is well documented

that obesity is positively linked to increased bone mineral density

(BMD) and reduced fracture risk through body weight increase.

Hyper-triglycemia and hypo-HDL-cholesterolemia, which are frequently

accompanied with obesity, might also protect against fracture. On the

other hand, clinical observations on diabetic patients suggest that

hyperglycemia per se tends to reduce BMD and to increase fracture risk

in contrast to the above factors. Thus, BMD and fracture risk in

patients with the metabolic syndrome may be determined by the balance

between beneficial effects of obesity and dyslipidemia versus

detrimental ones of hyperglycemia on bone.

PMID: 18445878

http://www.ncbi.nlm.nih.gov/pubmed/18445878

Not an MD