Re: RESEARCH - Association between the aggrecan gene and RA

[Guest guest]

;

 

I just need to know.  Is this about RA gene?  Also does it say anything about

getting RA from family that had RA? Thanks

 

Clora

 

******************************************

 

--- On Mon, 11/17/08, <Rheumatoid.Arthritis.Support@...>

wrote:

From: <Rheumatoid.Arthritis.Support@...>

Subject: [ ] RESEARCH - Association between the aggrecan gene and RA

" " < >

Date: Monday, November 17, 2008, 9:08 AM

J Rheumatol. 2008 Nov 1. [Epub ahead of print]

Association Between the Aggrecan Gene and Rheumatoid Arthritis.

De Souza TB, Mentz EF, Brenol CV, Xavier RM, Brenol JC, Chies JA, Simon D.

From the Curso de Biologia and Programa de Pós-Graduação em

Diagnóstico Genético e Molecular, Universidade Luterana do Brasil,

Canoas, Brazil; Serviço de Reumatologia, Hospital de Clínicas de Porto

Alegre, Porto Alegre, Brazil; and Departamento de Genética,

Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

OBJECTIVE: Genetic and environmental factors seem to be involved in

the onset of rheumatoid arthritis (RA). We analyzed whether a variable

number of tandem repeats (VNTR) polymorphism in the aggrecan gene was

associated to RA.

METHODS: The study population comprised 170 European-derived Brazilian

patients with diagnosis of RA. The control group comprised 148

European-derived Brazilian healthy blood donors. The aggrecan VNTR

polymorphism was genotyped by DNA amplification by polymerase chain

reaction, followed by electrophoresis in polyacrylamide gel. RESULTS:

There was a statistically significant higher frequency of alleles of

shorter length in the patient group compared to controls (p = 0.001),

suggesting that individuals carrying short alleles are more likely to

develop RA. There was no association between short alleles and

clinical characteristics of RA.

CONCLUSION: Our results provide evidence of an association between the

aggrecan gene VNTR polymorphism and RA.

PMID: 19004047

http://www.ncbi. nlm.nih.gov/ pubmed/19004047

Not an MD

[Guest guest]

In a message dated 11/17/2008 9:36:04 P.M. Central Standard Time,

Rheumatoid.Arthritis.Support@... writes:

We know that both genes and environment are important.

In this study, the researchers found that a certain genetic variation

is associated with RA.

This one didn't deal with the issue of inheritance; however, RA isn't

inherited directly from our parents or other ancestors.

In the video I watched on Youtube yesterday (from Shirley), they injected

the RA gene into mice, but they didn't get RA unless certain things happened in

the environment. One of the biggest was smoking.

dd

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[Guest guest]

Hi, Clora,

There are several genes associated with RA, but probably more will be

discovered. The exact cause of the disease is still unknown.

We know that both genes and environment are important.

In this study, the researchers found that a certain genetic variation

is associated with RA.

This one didn't deal with the issue of inheritance; however, RA isn't

inherited directly from our parents or other ancestors.

Not an MD

On Mon, Nov 17, 2008 at 9:16 AM, Clora <clora4jesus@...> wrote:

> ;

>

> I just need to know. Is this about RA gene? Also does it say anything

> about getting RA from family that had RA? Thanks

>

> Clora

[Guest guest]

and group;

 

My grandfather on my moms side had RA

My grandmother on my dads side had RA

Fortunately my mom and dad or my 9 brothers

and sisters don't have RA.

 

I have RA.  I guesss my parents parents sent it down to me from their mom and

dad.  I am so glad my family don't have RA.

At least that gene missed my family.  That is strange how RA gene will attack

only certain members of families.  Like the luck of the draw or Unlucky draw.  

 

 

Thanks .  How did my family escape it do you know?   Could my daughters

develope it?  THey are in their 30s.  How can people avoid RA or is it possible

to avoid it?  Sorry for all the questions.

 

hugs Clora

 

> ;

>

> I just need to know. Is this about RA gene? Also does it say anything

> about getting RA from family that had RA? Thanks

>

> Clora

[Guest guest]

Clora,

As I said, the exact cause of RA is unknown. It's thought to be due to

a combination of several genes and environmental influences - a

multifactorial disease. We can't predict with certainty who will

develop it.

In only approximately 20% (depending on the study - it could be lower)

of identical twin sets will both in the pair have RA. So there's much

more to it than just genes.

Women are more likely to develop RA than men (about 3:1), so hormonal

contributions are probably important.

You don't have to have an ancestor who had it. You could just wind up

with an unlucky combination of genes and environmental exposures.

Even if some of your ancestors did have RA, you won't necessarily

develop it. It's not passed down to offspring as something like eye

color is.

As dd mentioned, one known and significant trigger is smoking. So,

urge your daughters not to smoke. An excellent diet, plenty of

exercise, and other common sense healthy living will serve them well,

regardless of whether they are genetically predisposed to RA.

Not an MD

On Mon, Nov 17, 2008 at 11:16 PM, Clora <clora4jesus@...> wrote:

> and group;

>

> My grandfather on my moms side had RA

> My grandmother on my dads side had RA

> Fortunately my mom and dad or my 9 brothers

> and sisters don't have RA.

>

> I have RA. I guesss my parents parents sent it down to me from their mom

> and dad. I am so glad my family don't have RA.

> At least that gene missed my family. That is strange how RA gene will

> attack only certain members of families. Like the luck of the draw or

> Unlucky draw.

>

>

> Thanks . How did my family escape it do you know? Could my daughters

> develope it? THey are in their 30s. How can people avoid RA or is it

> possible to avoid it? Sorry for all the questions.

>

> hugs Clora

[Guest guest]

Hi Group,

 

It's funny that they have found a connection between smoking and RA. No one else

in my family (that we know of) has ever had RA, I'm the first. I'm also the only

one who quit smoking over 15 years ago, the rest of my family still does. I am

also the only one who has looked for a cleaner enviroment to live in and changed

my eating habits prior to my RA. Go figure!

 

Betsy

[Guest guest]

Hi , I know the concordance for identical twins is low, but have you heard

anything about what % have some kind of autoimmune issue?  For example, the twin

might not have RA, but maybe lupus or MS or something else? 

________________________________

From: <Rheumatoid.Arthritis.Support@...>

Sent: Tuesday, November 18, 2008 7:34:11 AM

Subject: Re: [ ] RESEARCH - Association between the aggrecan gene and

RA

Clora,

As I said, the exact cause of RA is unknown. It's thought to be due to

a combination of several genes and environmental influences - a

multifactorial disease. We can't predict with certainty who will

develop it.

In only approximately 20% (depending on the study - it could be lower)

of identical twin sets will both in the pair have RA. So there's much

more to it than just genes.

Women are more likely to develop RA than men (about 3:1), so hormonal

contributions are probably important.

You don't have to have an ancestor who had it. You could just wind up

with an unlucky combination of genes and environmental exposures.

Even if some of your ancestors did have RA, you won't necessarily

develop it. It's not passed down to offspring as something like eye

color is.

As dd mentioned, one known and significant trigger is smoking. So,

urge your daughters not to smoke. An excellent diet, plenty of

exercise, and other common sense healthy living will serve them well,

regardless of whether they are genetically predisposed to RA.

Not an MD

On Mon, Nov 17, 2008 at 11:16 PM, Clora <clora4jesus> wrote:

> and group;

>

> My grandfather on my moms side had RA

> My grandmother on my dads side had RA

> Fortunately my mom and dad or my 9 brothers

> and sisters don't have RA.

>

> I have RA. I guesss my parents parents sent it down to me from their mom

> and dad. I am so glad my family don't have RA.

> At least that gene missed my family. That is strange how RA gene will

> attack only certain members of families. Like the luck of the draw or

> Unlucky draw.

>

>

> Thanks . How did my family escape it do you know? Could my daughters

> develope it? THey are in their 30s. How can people avoid RA or is it

> possible to avoid it? Sorry for all the questions.

>

> hugs Clora

[Guest guest]

Betsy, maybe you had already messed up your genes by the previous

smoking. That's what I think about myself, anyway. I quit smoking

almost 15 years ago, but I had already done lots of damage to myself.

It is strange how things happen, though. I started exercising and

changed my eating habits and managed to lose some excess weight, and

then I got RA. Of course that was not the reason I got it.

Sue

On Tuesday, November 18, 2008, at 08:55 AM, Farchette wrote:

>

> It's funny that they have found a connection between smoking and RA.

> No one else in my family (that we know of) has ever had RA, I'm the

> first. I'm also the only one who quit smoking over 15 years ago, the

> rest of my family still does. I am also the only one who has looked

> for a cleaner enviroment to live in and changed my eating habits prior

> to my RA. Go figure!

[Guest guest]

Kate, that is an excellent question. I'm not 100% sure of the answer.

My sense of the situation is that, in the overwhelming majority of the

cases, the other twin remains free on any autoimmune disease. I think

his or her risk for developing a similar immune system problem would

be that of the other siblings in the family (which is far less than

the risk of developing the same disease as his or her twin).

I did find this weirdo case where one twin had RA and the other had AS:

http://cat.inist.fr/?aModele=afficheN & cpsidt=4870658

Not an MD

On Tue, Nov 18, 2008 at 8:07 AM, Fair <kalfoley@...> wrote:

> Hi , I know the concordance for identical twins is low, but have you

> heard anything about what % have some kind of autoimmune issue? For

> example, the twin might not have RA, but maybe lupus or MS or something

> else?