Re: REVIEW - Anti-TNF-induced lupus/

[Guest guest]

Well " to start the enbrel or not to start the enbrel, that is the question "

atleast in my particular case. I have till July to make my full decision but

because of articles like this I just don't know. Just don't want my MCTD to rear

up along with my RA.

Sucks to say the least.

>

> Rheumatology Advance Access published online on May 4, 2009

> Rheumatology, doi:10.1093/rheumatology/kep080

>

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> Review

>

>

> Anti-TNF-induced lupus

>

>

> Emma L. 1, Stephan Gadola1,2 and J. 1

> 1Department of Rheumatology, Southampton University Hospitals NHS

> Trust and 2Division of Infection, Inflammation and Repair, School of

> Medicine, Southampton University, Southampton, UK.

>

>

> Abstract

>

> The use of protein-based anti-TNF- therapies such as antibodies and

> soluble TNF- receptors is commonly associated with the induction of

> autoantibodies, whereas anti-TNF-induced lupus (ATIL) is rare. ATIL

> can occur with any of the available TNF inhibitors, but the frequency

> and clinical characteristics of ATIL vary between different drugs.

> Cutaneous, renal and cerebral involvement as well as dsDNA antibodies

> are more common in ATIL compared to classical drug-induced lupus

> (DIL), suggesting different pathogenic mechanisms of ATIL and DIL.

> True ATIL must be clinically differentiated from mixed CTD, SLE or

> overlap syndromes unmasked, but not induced, by anti-TNF- treatment of

> unclassified polyarthritis. The pathogenesis of ATIL is still unknown.

> Concomitant immunosuppression can reduce autoantibody formation in

> ATIL, and withdrawal of anti-TNF- therapy usually leads to resolution

> of symptoms. Steroids and/or immunosuppressive therapy may be required

> in severe cases.

>

>

> http://rheumatology.oxfordjournals.org/cgi/content/abstract/kep080v1?papetoc

>

>

>

> Not an MD

>

[Guest guest]

That is why I chose the Enbrel over the others. I'm pretty sure I will be

starting it in July but it is just a bit stressful.

> >

> >

> > Well " to start the enbrel or not to start the enbrel, that is the

> > question " atleast in my particular case. I have till July to make my full

> > decision but because of articles like this I just don't know. Just don't

> > want my MCTD to rear up along with my RA.

> >

> > Sucks to say the least.

> >

>