Re: Re: Cimzia Approved for Rheumatoid Arthritis

[Guest guest]

Doreen,

Some researchers have concluded that people with RA have a greater

risk of developing lymphoma because of the disease itself, not because

of the medications/biologics which are used to treat it. It may be

that uncontrolled, severe inflammation is linked with lymphoma risk.

Not an MD

On Sat, May 16, 2009 at 6:03 AM, Mimi <mimi212@...> wrote:

>

>

> Hi Arshad - all DMARDS and Biologics carry similar risks. All medications on

> the market carry their own risks and benefits as well. It is important to

> remember that the manufacturers are required to report any and all side

> effects that a particular medication may carry - even the most remote of

> possibilities. That does not mean that we will definitely contract a

> lymphoma if we take a particular medication - it just means the risk is

> there. Sometimes the risks outweigh the benefits.

>

> This was just an article that I received via email and I thought I'd share.

> There are many people out there who have run out of options to help control

> their RA. This represents just another option that has recently been

> approved.

>

> Wishing everyone a beautiful and pain free day.....Doreen

[Guest guest]

Hi guys, well if you look at FDA website for biological dmards, you will see the

same information I posted. FDA has listed lymphomas for young adults and even

kids for patients who take these biologic dmard drugs. I never look at drug

company data anymore because so many of them are are distorted. They are finding

out every day how big pharma is distorting data. Just google and

research.  Please also look at website askapatient.com for enbrel and related

drugs. There are lots of problems for biologic dmards. Even my rheumy admitted

that I could develop shingles and lymphomas using biologics. He also stated they

give biologics as a last resort(Just think carefully why this the last

resort:)) after trying other safer dmards since biologics have a tendency for

very serious side effects. If there is a need and nothing can stop the

progression then by all means one has to take the drug no matter what the

consequences.

 

Arshad

[Guest guest]

I understand, Doreen. I was just adding that there is a possiblity

that lymphoma may not be a side effect of the TNF blockers.

Not an MD

On Sun, May 17, 2009 at 10:58 AM, Mimi <mimi212@...> wrote:

>

>

> - I agree. It was just that Arshad said that Cimzia and " all biologic

> DMARDS " can cause lymphoma. I was just trying to clarify for him.....Doreen

>

[Guest guest]

Arshad,

The causal relationship between the TNF blockers and lymphoma is not proven.

Lymphoma in RA patients was an issue before the development of the biologics.

The anti-TNF biologics are not agents of last resort.

The biologic rituximab is used to treat both certain types of lymphoma

and rheumatoid arthritis.

Not an MD

On Sun, May 17, 2009 at 8:26 PM, Arshad Amdani <a_amdani2000@...> wrote:

>

>

>

> Hi guys, well if you look at FDA website for biological dmards, you will see

> the same information I posted. FDA has listed lymphomas for young adults and

> even kids for patients who take these biologic dmard drugs. I never look at

> drug company data anymore because so many of them are are distorted. They

> are finding out every day how big pharma is distorting data. Just google and

> research.  Please also look at website askapatient.com for enbrel and

> related drugs. There are lots of problems for biologic dmards. Even my

> rheumy admitted that I could develop shingles and lymphomas using biologics.

> He also stated they give biologics as a last resort(Just think carefully why

> this the last resort:)) after trying other safer dmards since biologics have

> a tendency for very serious side effects. If there is a need and nothing can

> stop the progression then by all means one has to take the drug no matter

> what the consequences.

>

> Arshad

[Guest guest]

I personally know 2 people, 1 an RA patient and the other psoriatic arthritis

patient, who had lymphoma before going on an anti-TNF medication. Both their

doctors told them that there appears to be a higher risk of lymphoma in patients

with RA/PA/certain autoimmune diseases. Both are now on anti-TNF medications,

one on Enbrel, the other Humira.

*~ Kami ~*

Re: [ ] Re: Cimzia Approved for Rheumatoid Arthritis

Arshad,

The causal relationship between the TNF blockers and lymphoma is not proven.

Lymphoma in RA patients was an issue before the development of the biologics.

The anti-TNF biologics are not agents of last resort.

The biologic rituximab is used to treat both certain types of lymphoma

and rheumatoid arthritis.

Not an MD

On Sun, May 17, 2009 at 8:26 PM, Arshad Amdani <a_amdani2000@...> wrote:

>

>

>

> Hi guys, well if you look at FDA website for biological dmards, you will see

> the same information I posted. FDA has listed lymphomas for young adults and

> even kids for patients who take these biologic dmard drugs. I never look at

> drug company data anymore because so many of them are are distorted. They

> are finding out every day how big pharma is distorting data. Just google and

> research. Please also look at website askapatient.com for enbrel and

> related drugs. There are lots of problems for biologic dmards. Even my

> rheumy admitted that I could develop shingles and lymphomas using biologics.

> He also stated they give biologics as a last resort(Just think carefully why

> this the last resort:)) after trying other safer dmards since biologics have

> a tendency for very serious side effects. If there is a need and nothing can

> stop the progression then by all means one has to take the drug no matter

> what the consequences.

>

> Arshad

[Guest guest]

I think I've said this before to the group: " For me to stop Enbrel,

they would have to pry it from my cold, dead hands. "

I have been on Enbrel for over five years, and have no adverse side

effects, except an occasional mild injection site reaction. Nor do I

get frequent infections. It works wonders for me; I can hardly even

tell that I have RA.

I had shingles and breast cancer after my RA symptoms started, but way

before I started Enbrel. We have to weigh the risks and benefits. I

fear the RA much more than I do the Enbrel. I like it so well that I

even bought a little stock in the company.

Sue

On May 17, 2009, at 9:26 PM, Arshad Amdani wrote:

>

> Hi guys, well if you look at FDA website for biological dmards, you

> will see the same information I posted. FDA has listed lymphomas for

> young adults and even kids for patients who take these biologic

> dmard drugs. I never look at drug company data anymore because so

> many of them are are distorted. They are finding out every day how

> big pharma is distorting data. Just google and research. Please

> also look at website askapatient.com for enbrel and related drugs.

> There are lots of problems for biologic dmards. Even my rheumy

> admitted that I could develop shingles and lymphomas using

> biologics. He also stated they give biologics as a last resort(Just

> think carefully why this the last resort:)) after trying other safer

> dmards since biologics have a tendency for very serious side

> effects. If there is a need and nothing can stop the progression

> then by all means one has to take the drug no matter what the

> consequences.

[Guest guest]

Sue, you have said that before. Your new nickname is now " Charlton Heston. "

I know Stan will have fun with that.

Not an MD

On Mon, May 18, 2009 at 2:56 PM, marysue <marysue@...> wrote:

>

>

> I think I've said this before to the group: " For me to stop Enbrel,

> they would have to pry it from my cold, dead hands. "

>

> I have been on Enbrel for over five years, and have no adverse side

> effects, except an occasional mild injection site reaction. Nor do I

> get frequent infections. It works wonders for me; I can hardly even

> tell that I have RA.

>

> I had shingles and breast cancer after my RA symptoms started, but way

> before I started Enbrel. We have to weigh the risks and benefits. I

> fear the RA much more than I do the Enbrel. I like it so well that I

> even bought a little stock in the company.

>

> Sue

[Guest guest]

LOL, .

Sue

On May 19, 2009, at 11:57 AM, wrote:

> Sue, you have said that before. Your new nickname is now " Charlton

> Heston. "

>

> I know Stan will have fun with that.

>

[Guest guest]

Do you you know how much pressure that puts on me? Now if I don't come up with

something funny everyone's gonna think I can't do it, then we're both screwed

and you're gonna blame me.

1. Charlton Heston on the mountain, stone tablets in hand, one reads " ENBREL "

the other reads " DIRECTIONS FOR USE " .

2. In Will Penny Charlton Heston lays in the back of a wagon on the virge of

death, the drivers are excited 'cause they're going into town when Charlton

Heston whispers, " you boys remember to get my Enbrel before ya start drinking. "

3. Charlton Heston in the future, he discovers how they make Enbrel, " they make

it out of people, " he screams, " they make it out of people! "

4. Charlton Heston alone in the world, he's surrounded by vampires. One of the

vamps breaks in, he looks horrible, all white with black eyes and broken bones.

Charlton Heston mummers, " that's what happens when you don't take you're

Enbrel. "

5. One of of his most famous lines, " take you damn arthritic paws off me you

stinking ape! "

And my favorite true story about Charlton Heston was when he told us about the

filming of Ben Hur. He went to the Stunt Director very concerned about the

chariot race sequence, it was a huge deal to film this thing and they only had a

limited window of opportunity to get it right. He very seriously told the Stunt

Director that he could drive the chariot but he wasn't really sure he could

" win " the race. The Stunt Director looked at him blankly (as though he were

developmentally disabled) then finally said sarcastically, " you just stay on the

### damn chariot, I guarantee you're win the ###ing race! "

Stan

Seattle, Sun breaks.

Sue, you have said that before. Your new nickname is now " Charlton Heston. "

I know Stan will have fun with that.

Not an MD

On Mon, May 18, 2009 at 2:56 PM, marysue <marysue@...> wrote:

>

>

> I think I've said this before to the group: " For me to stop Enbrel,

> they would have to pry it from my cold, dead hands. "

>

> I have been on Enbrel for over five years, and have no adverse side

> effects, except an occasional mild injection site reaction. Nor do I

> get frequent infections. It works wonders for me; I can hardly even

> tell that I have RA.

>

> I had shingles and breast cancer after my RA symptoms started, but way

> before I started Enbrel. We have to weigh the risks and benefits. I

> fear the RA much more than I do the Enbrel. I like it so well that I

> even bought a little stock in the company.

>

> Sue

[Guest guest]

I'm really happy that you felt compelled to write something this

hilarious, Stan! I think I'll pressure you daily.

Not an MD

On Tue, May 19, 2009 at 1:49 PM, <stanpfister@...> wrote:

>

>

>

>

> Do you you know how much pressure that puts on me? Now if I don't come up

> with something funny everyone's gonna think I can't do it, then we're both

> screwed and you're gonna blame me.

>

> 1. Charlton Heston on the mountain, stone tablets in hand, one reads

> " ENBREL " the other reads " DIRECTIONS FOR USE " .

>

> 2. In Will Penny Charlton Heston lays in the back of a wagon on the virge of

> death, the drivers are excited 'cause they're going into town when Charlton

> Heston whispers, " you boys remember to get my Enbrel before ya start

> drinking. "

>

> 3. Charlton Heston in the future, he discovers how they make Enbrel, " they

> make it out of people, " he screams, " they make it out of people! "

>

> 4. Charlton Heston alone in the world, he's surrounded by vampires. One of

> the vamps breaks in, he looks horrible, all white with black eyes and broken

> bones. Charlton Heston mummers, " that's what happens when you don't take

> you're Enbrel. "

>

> 5. One of of his most famous lines, " take you damn arthritic paws off me you

> stinking ape! "

>

> And my favorite true story about Charlton Heston was when he told us about

> the filming of Ben Hur. He went to the Stunt Director very concerned about

> the chariot race sequence, it was a huge deal to film this thing and they

> only had a limited window of opportunity to get it right. He very seriously

> told the Stunt Director that he could drive the chariot but he wasn't really

> sure he could " win " the race. The Stunt Director looked at him blankly (as

> though he were developmentally disabled) then finally said sarcastically,

> " you just stay on the ### damn chariot, I guarantee you're win the ###ing

> race! "

>

> Stan

[Guest guest]

whew!

Stan

I'm really happy that you felt compelled to write something this

hilarious, Stan! I think I'll pressure you daily.

Not an MD