Re: Is RA an inherited disease?

[Guest guest]

Hi : I don't know that either. But I had a Great Aunt who was so

crippled with it, back then they called it " Rheumitisum. " I think she

really had RA. Back then no one talked about stuff like that.

Wishing you pain free days ahead.

Hugs,

Barbara

--- In , " ldydewinter04 " <ldydewinter@...>

wrote:

>

> I know has probably posted several articles on this before, but

my brain fogs up. Has RA been proven to be genetic and passed down from

parents to kids or grandparents to grandkids? Neither of my parents have

RA (but neither have they been tested) but my paternal grandfather,

grandmother and her siblings did. I just found this out this past family

reunion. My great uncle apparently had 'lockjaw' like I do from his RA.

I'm just worried about my children who are 2 and 7. I didn't show RA

signs until after the birth of my first, but I thought I was just doing

something wrong mechanically at work. Now I know it was probably the

first signs of RA.

>

>

[Guest guest]

I don't know how correct I am on this but it's my belief that autoimmune

diseases, of which RA is one, are hereditary. My mother had vasculitus, my

sister has Raynards and my son has been diagnosed with the markers for

autoimmune inner ear disease, AIED, I'm just praying that sleeps forever.

in PA

[ ] Is RA an inherited disease?

I know has probably posted several articles on this before, but my brain

fogs up. Has RA been proven to be genetic and passed down from parents to kids

or grandparents to grandkids? Neither of my parents have RA (but neither have

they been tested) but my paternal grandfather, grandmother and her siblings did.

I just found this out this past family reunion. My great uncle apparently had

'lockjaw' like I do from his RA. I'm just worried about my children who are 2

and 7. I didn't show RA signs until after the birth of my first, but I thought I

was just doing something wrong mechanically at work. Now I know it was probably

the first signs of RA.

[Guest guest]

Because we have RA, an autoimmune disorder, our children are more likely to

develop an autoimmune disorder.  I have RA, my husband has MS, and I am sure

this played a role in my so developing type 1 diabetes, an autoimmune disease, a

few years ago.

So yes, having RA increases your children's chances of developing RA or another

autoimmune disorder.  It is something to be aware of, to look for, but not stay

up at night worrying about it.

Shandi

[Guest guest]

,

It's believed that there is a genetic prerequisite for RA, but it

isn't inherited in the usual sense. It's not just one gene, but

several genes. One individual may have one unlucky combination of

genes, and a different individual may have another unlucky

combination. The genes responsible are still under investigation.

In studies of identical twins, the concordance rate hasn't been

demonstrated to be over 20%. So, you don't have to worry too much

about your children. They are at higher risk than other children, but

the absolute risk is not high.

In addition to the genes, one or more environmental triggers come

along and, eventually, the genetically susceptible immune system

begins to behave abnormally. All of the possible triggers are unknown.

Not an MD

On Sun, May 31, 2009 at 9:58 AM, ldydewinter04 <ldydewinter@...> wrote:

>

>

> I know has probably posted several articles on this before, but my

> brain fogs up. Has RA been proven to be genetic and passed down from parents

> to kids or grandparents to grandkids? Neither of my parents have RA (but

> neither have they been tested) but my paternal grandfather, grandmother and

> her siblings did. I just found this out this past family reunion. My great

> uncle apparently had 'lockjaw' like I do from his RA. I'm just worried about

> my children who are 2 and 7. I didn't show RA signs until after the birth of

> my first, but I thought I was just doing something wrong mechanically at

> work. Now I know it was probably the first signs of RA.

>

[Guest guest]

Hi- I have to wonder at times if all my problems started with me being an

enviromental chemist and catching Hep. A and then losing my gallbladder- in

1993-1994. All my problems started after that craziness. Could the combination

of chemcial exposure and illness have kicked this all off? No history of

autoimmune in the family before me. Hmmm. I 'retired' when I had my first kid

in 1999. SAHM, try to substitue at the school, but I get tired. I am good for

maybe 2 days then need 3 days to recover. Would I qualify of Disability? Thank

you- D. in south Louisiana

>

>

>

> So what you're saying is that if you had a genetic predisposition for RA

there's absolutely no chemical compound that could trigger it? One that the 20%

twin probably would have avoided. I ask because I've had a lot of unique

chemical exposure in my career working as a graphic artist and printer. Also,

should I have washed my genes more often?

>

>

>

> Stan,

>

> Steattle , Cloudy -clearing.

[Guest guest]

Only if those genes were standing up on their own, Stan. ROFLMAO.....Doreen

>

> So what you're saying is that if you had a genetic predisposition for RA

there's absolutely no chemical compound that could trigger it? One that the 20%

twin probably would have avoided. I ask because I've had a lot of unique

chemical exposure in my career working as a graphic artist and printer. Also,

should I have washed my genes more often?

>

> Stan,

>

> Steattle , Cloudy -clearing.