Re: ReGeneration of nerve meylin with PPE

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Rusty, can you paraphrase the article? I cannot view it for some reason.

This is a very interesting subject to me.

Rusty

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Renerration of nerve meylin with PPE

http://www.sciencedirect.com/science?_ob=ArticleURL & _udi=B6TWB-4846HWP-5 & _user=1\

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43053405f8013c795968e8679879f

[Guest guest]

Peripheral nerve regeneration with sustained release of poly(phosphoester)

microencapsulated nerve growth factor within nerve guide conduits

References and further reading may be available for this article. To view

references and further reading you must purchase this article..

Xiaoyun Xua, Woon-Chee Yeeb, Y. K. Hwangb, Hanry Yua, C.. A. Wana,

Shujun Gaoa, Kum-Loong Boonb, Hai-Quan Maoc, Kam W. Leonga, c and Shu Wang, , a,

da Molecular and Biomaterials Lab., Institute of Materials Research and

Engineering, National University of Singapore, 3 Research Link, Singapore

117602, Singapore

b National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore 308433,

Singapore

c Department of Biomedical Engineering, s Hopkins University, Baltimore

21205-2196, USA

d Department of Biological Science, National University of Singapore, Singapore

117597, Singapore

Received 29 October 2002;  accepted 19 January 2003. ; Available online 12

March 2003.

Abstract

Prolonged delivery of neurotrophic proteins to the target tissue is valuable in

the treatment of various disorders of the nervous system. We have tested in this

study whether sustained release of nerve growth factor (NGF) within nerve guide

conduits (NGCs), a device used to repair injured nerves, would augment

peripheral nerve regeneration. NGF-containing polymeric microspheres fabricated

from a biodegradable poly(phosphoester) (PPE) polymer were loaded into silicone

or PPE conduits to provide for prolonged, site-specific delivery of NGF. The

conduits were used to bridge a 10 mm gap in a rat sciatic nerve model. Three

months after implantation, morphological analysis revealed higher values of

fiber diameter, fiber population and fiber density and lower G-ratio at the

distal end of regenerated nerve cables collected from NGF microsphere-loaded

silicone conduits, as compared with those from control conduits loaded with

either saline alone, BSA

microspheres, or NGF protein without microencapsulation. Beneficial effects on

fiber diameter, G-ratio and fiber density were also observed in the permeable

PPE NGCs. Thus, the results confirm a long-term promoting effect of exogenous

NGF on morphological regeneration of peripheral nerves. The tissue-engineering

approach reported in this study of incorporation of a microsphere protein

release system into NGCs holds potential for improved functional recovery in

patients whose injured nerves are reconstructed by entubulation.

________________________________

To: mscured@...

Sent: Thu, January 14, 2010 9:44:00 AM

Subject: Re: ReGeneration of nerve meylin with PPE

 

Rusty, can you paraphrase the article? I cannot view it for some reason.

This is a very interesting subject to me.

Rusty <rustypatterson79@ yahoo.com>

Sent by: mscured@yahoogroups .com

01/14/2010 08:01 AM

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mscured@yahoogroups .com

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Renerration of nerve meylin with PPE

http://www.sciencedirect.com/science?_ob=ArticleURL & _udi=B6TWB-4846HWP-5 & _user=1\

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43053405f8013c795968e8679879f