Guest guest Posted December 4, 2009 Report Share Posted December 4, 2009 The drug does work. I have been on it for over 10 years and although I do not stay in remission as some say the pain does get way better than without the methotrexate. I am due another round of rituxin in January and hopefully it will last longer this time and leave me in less pain. The cold weather does me in every time and I try and deal with it. My hands and feet/knees and hip joints are what is bothering me the most now and am looking forward to at least be in less pain as I am now. So in my opinion the side effects are worth not being in so much pain. Irish Quote Link to comment Share on other sites More sharing options...
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