Re: RESEARCH - Relationship between pack-year history of smoking and response to TNF antagonists in patients with RA

[Guest guest]

I guess I'm very lucky that I have responded so well to Enbrel,

because with my history of smoking, I have a lot of pack years.

When filling out a questionnaire recently, there was a question about

the number of pack years in my smoking history. It was impossible to

calculate, because I smoked for 34-35 years and started out smoking

just a few cigarettes, but ending up smoking at least three packs a

day. If I hadn't quit on March 6, 1994, I think I'd probably be dead

now.

Sue

On May 28, 2009, at 9:27 AM, wrote:

>

> CONCLUSION: RA patients with a history of smoking were more likely to

> show a poor response to TNF antagonists. Response failure was

> associated with the intensity of previous smoking, irrespective of

> smoking status at initiation of anti-TNF therapy.

>

[Guest guest]

Well, that sucks! I have been smoke free for over 3 years now. I pray I have

good results with the Enbrel in spite of my past history of smoking.....Doreen

>

> J Rheumatol. 2009 May 15.

>

>

> Relationship Between Pack-year History of Smoking and Response to

> Tumor Necrosis Factor Antagonists in Patients with Rheumatoid

> Arthritis.

>

>

> Mattey DL, Brownfield A, Dawes PT.

> From the Staffordshire Rheumatology Centre, University Hospital of

> North Staffordshire; and Institute of Science and Technology in

> Medicine, Keele University, Keele, Staffordshire, England.

>

>

> OBJECTIVE: To determine whether there is a quantitative relationship

> between smoking history and response to therapy with tumor necrosis

> factor (TNF) antagonists.

>

> METHODS: A history of cigarette smoking was obtained from a

> questionnaire completed by each patient starting therapy with TNF

> antagonists since 2002 (n = 154). A core set of demographic and

> clinical variables was recorded at baseline and at 3 and 12 months.

> The extent of smoking was quantified in pack-years (py), with 1 py

> equivalent to 20 cigarettes per day for 1 year. The association

> between smoking intensity and response was assessed using

> contingency tables and logistic regression analysis. Response to

> therapy was defined according to the European League Against

> Rheumatism improvement criteria.

>

> RESULTS: There was an increasing trend of no response at 3 and 12

> months with increasing py history [p (trend) = 0.008 and 0.003,

> respectively]. The change in Disease Activity Score (DAS)28 over the

> first 3 months was inversely associated with the number of py (r =

> -0.28, p = 0.002). The association of py history with response

> failure was independent of age, sex, disease duration, baseline

> disease activity score (DAS28), Health Assessment Questionnaire

> (HAQ) score, IgM rheumatoid factor, and smoking at baseline. The

> most significant effect was seen in patients treated with

> infliximab.

>

> CONCLUSION: RA patients with a history of smoking were more likely

> to show a poor response to TNF antagonists. Response failure was

> associated with the intensity of previous smoking, irrespective of

> smoking status at initiation of anti-TNF therapy.

>

>

> PMID: 19447930

>

> http://www.ncbi.nlm.nih.gov/pubmed/19447930

>

>

>

> Not an MD

>

[Guest guest]

Congratulations on your smoke freedom, Sue - and for sticking with it for all

these years! I've been smoke free since April 17, 2006. I just hope my pack

years won't affect how the Enbrel works for me - although during those smoking

years, I rarely went over 1½ packs per day.....Doreen

>

> I guess I'm very lucky that I have responded so well to Enbrel,

> because with my history of smoking, I have a lot of pack years.

>

> When filling out a questionnaire recently, there was a question

> about the number of pack years in my smoking history. It was

> impossible to calculate, because I smoked for 34-35 years and

> started out smoking just a few cigarettes, but ending up smoking at

> least three packs a day. If I hadn't quit on March 6, 1994, I think

> I'd probably be dead now.

>

> Sue

[Guest guest]

I certainly have had good results with Enbrel, Doreen, and I'm sure I

smoked way more than you did. So good luck, and think positive

thoughts. LOL.

Sue

On May 29, 2009, at 7:59 AM, Mimi wrote:

> Well, that sucks! I have been smoke free for over 3 years now. I

> pray I have good results with the Enbrel in spite of my past history

> of smoking.....Doreen

>

[Guest guest]

I am certainly an exception to this finding. I was a very heavy

smoker, had smoked for 34 years and was up to at least three packs a

day. But I have a wonderful response to Enbrel, which of course is one

of the TNF antagonists. I am very lucky!

Sue

On Jan 29, 2010, at 5:27 PM, wrote:

>

> CONCLUSION: RA patients with a history of smoking were more likely to

> show a poor response to TNF antagonists. Response failure was

> associated with the intensity of previous smoking, irrespective of

> smoking status at initiation of anti-TNF therapy.

[Guest guest]

,

Maybe they are going to junk mail/spam? Check to see if my address is

in your contact list.

Not an MD

On Fri, Jan 29, 2010 at 6:43 PM, <ltdavis_jrdavis@...> wrote:

> Can anyone tell me why I'm not getting 's original posts??

>

> Thx -- in Sc