RESEARCH - High-dose chemotherapy followed by autologous stem cell transplantation in the treatment of severe refractory multisystem autoimmune diseases

[Guest guest]

Orv Hetil. 2008 Jul 27;149(30):1405-12.

[High-dose chemotherapy followed by autologous CD34+ stem cell

transplantation in the treatment of severe refractory multisystem

autoimmune diseases of adults--first experiences in Hungary][Article

in Hungarian]

Váróczy L, Illés A, Kiss E, Szekanecz Z, Soltész P, Sipka S, Kiss A,

Udvardy M, Szegedi G, Zeher M.

Debreceni Egyetem, Orvos- és Egészségtudományi Centrum, Altalános

Orvostudományi Kar, Belgyógyászati III. Belgyógyászati Klinika,

Belgyógyászati Intézet Debrecen.

High dose chemotherapy followed by autologous stem cell support is a

promising therapeutical approach in the treatment of severe refractory

multisystem autoimmune diseases. The aim of this study was to perform

the authors' first experiences in this field. Results: Between August

2006 and November 2007 autologous stem cell transplantation was

performed for seven patients: two of them had systemic lupus

erythematosus, four of them had rheumatoid arthritis and one of them

had systemic sclerosis. Cyclophosphamide plus colony stimulating

factor were administered to mobilize stem cells. The conditioning

protocol included high dose cyclophosphamide (200 mg/kg) and

anti-thymocyte globulin (9 mg/kg). The re-infused stem cells were

successfully engrafted by all patients. One of the lupus patients died

on the 46th day due to a lethal cytomegalovirus infection, but the

rest of them had no severe complications. Complete remission of their

diseases and significant improvement in their quality of life were

observed during a mean follow-up period of 10 months.

Conclusions: Autologous stem cell therapy can be effectively

administered in special cases of severe autoimmune disorders.

PMID: 18621599

http://www.ncbi.nlm.nih.gov/pubmed/18621599

Not an MD

[Guest guest]

This is amazing and could be awesome!! MicheleBB

>

> Orv Hetil. 2008 Jul 27;149(30):1405-12.

>

>

> [High-dose chemotherapy followed by autologous CD34+ stem cell

> transplantation in the treatment of severe refractory multisystem

> autoimmune diseases of adults--first experiences in Hungary][Article

> in Hungarian]

>

>

> Váróczy L, Illés A, Kiss E, Szekanecz Z, Soltész P, Sipka S, Kiss A,

> Udvardy M, Szegedi G, Zeher M.

> Debreceni Egyetem, Orvos- és Egészségtudományi Centrum, Altalános

> Orvostudományi Kar, Belgyógyászati III. Belgyógyászati Klinika,

> Belgyógyászati Intézet Debrecen.

>

>

> High dose chemotherapy followed by autologous stem cell support is a

> promising therapeutical approach in the treatment of severe refractory

> multisystem autoimmune diseases. The aim of this study was to perform

> the authors' first experiences in this field. Results: Between August

> 2006 and November 2007 autologous stem cell transplantation was

> performed for seven patients: two of them had systemic lupus

> erythematosus, four of them had rheumatoid arthritis and one of them

> had systemic sclerosis. Cyclophosphamide plus colony stimulating

> factor were administered to mobilize stem cells. The conditioning

> protocol included high dose cyclophosphamide (200 mg/kg) and

> anti-thymocyte globulin (9 mg/kg). The re-infused stem cells were

> successfully engrafted by all patients. One of the lupus patients died

> on the 46th day due to a lethal cytomegalovirus infection, but the

> rest of them had no severe complications. Complete remission of their

> diseases and significant improvement in their quality of life were

> observed during a mean follow-up period of 10 months.

>

> Conclusions: Autologous stem cell therapy can be effectively

> administered in special cases of severe autoimmune disorders.

>

>

> PMID: 18621599

>

> http://www.ncbi.nlm.nih.gov/pubmed/18621599

>

>

>

> Not an MD

>