RESEARCH - Vitamin D and serum cytokines

[Guest guest]

Int J Endocrinol. 2010; 2010: 305054.

Published online 2010 August 12. doi: 10.1155/2010/305054.

PMCID: PMC2943086

Vitamin D and Serum Cytokines in a Randomized Clinical Trial

Eleanor Yusupov,* Li-Ng, Simcha Pollack, K. Yeh, Mageda

Mikhail, and F. Aloia

Winthrop University Hospital, Bone Mineral Research Center, 222

Station Plaza North, Suite 350A, Mineola, NY 11501, USA

Abstract

Background. The role of vitamin D in the body's ability to fight

influenza and URI's may be dependent on regulation of specific

cytokines that participate in the host inflammatory response. The aim

of this study was to test the hypothesis that vitamin D can influence

intracellular signaling to regulate the production of cytokines.

Subjects and Methods. This study was a 3-month prospective

placebo-controlled trial of vitamin D3 supplementation in ambulatory

adults [Li-Ng et al., 2009]. 162 volunteers were randomized to receive

either 50ìg/d (2000 IU) of vitamin D3 or matching placebo. 25(OH)D and

the levels of 10 different cytokines (IL-2, 4, 5, 6, 8, 10, 13,

GM-CSF, IFN-ã, TNF-á) were measured in the serum of participants at

baseline and the final visit. There were 6 drop-outs from the active

vitamin D group and 8 from the placebo group.

Results. In the active vitamin D group, we found a significant median

percent decline in levels of GM-CSF (-62.9%, P < .0001), IFN-ã

(-38.9%, P < .0001), IL-4 (-50.8%, P = .001), IL-8 (-48.4%, P <

..0001), and IL-10 (-70.4%, P < .0001). In the placebo group, there

were significant declines for GM-CSF (-53.2%, P = .0007) and IFN-ã

(-34.4%, P = .0011). For each cytokine, there was no significant

difference in the rate of decline between the two groups. 25(OH)D

levels increased in the active vitamin D group from a mean of 64.3 ±

25.4nmol/L to 88.5 ± 23.2nmol/L.

Conclusions. The present study did not show that vitamin D3

supplementation changed circulating cytokine levels among healthy

adults.

Read the full article here:

http://www.ncbi.nlm.nih.gov/sites/ppmc/articles/PMC2943086/

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