Re: RESEARCH - Immune-mediated skin lesions in patients treated with TNF inhibitors

[Guest guest]

What is weird for me is that I have a skin lesion on my stomach that cleared up

when I started Enbrel. Now that I have discontinued it for almost 3 weeks due to

being sick, it is coming back.

>

> Scand J Rheumatol. 2009;38(5):328-31.

>

>

> Immune-mediated skin lesions in patients treated with anti-tumour

> necrosis factor alpha inhibitors.

>

>

> Exarchou SA, Voulgari PV, Markatseli TE, Zioga A, Drosos AA.

> Rheumatology Clinic, Department of Internal Medicine, Medical School,

> University of Ioannina, Ioannina, Greece.

>

>

> Abstract

>

> OBJECTIVE: To describe immune-mediated skin lesion (IMSL) development

> in patients during anti-tumour necrosis factor (TNF) therapy.

>

> METHODS: Two hundred and fifty-two patients with rheumatoid arthritis

> (RA) and 183 with spondyloarthropathies (SpA) treated with anti-TNF

> inhibitors were analysed to identify IMSLs.

>

> RESULTS: Of the 252 patients with RA (146 treated with infliximab, 72

> with adalimumab, and 34 with etanercept), 32 developed IMSLs. Eleven

> patients developed psoriatic skin lesions, 10 presented with granuloma

> annulare (GA), five had skin vasculitis, two alopecia areata, two

> discoid lupus erythematosus, one lichenoid eruption (lichen planus),

> and one vitiligo. Of the 183 patients with SpA (138 treated with

> infliximab, 37 with etanercept, and eight with adalimumab), 10 cases

> with IMSLs were identified. All were treated with infliximab. More

> specifically, six patients with ankylosing spondylitis (AS) developed

> psoriatic skin lesions, one developed GA, one lichen planus, and one

> alopecia areata. In addition, one patient with psoriatic arthritis

> (PsA) developed skin vasculitis. The occurrence of these IMSLs ranged

> from 3 to 36 months with a median of 20 months. Of all the patients

> with IMSL development, two with psoriatic skin lesions, two with GA,

> and one with vasculitis stopped anti-TNF therapy because of the extent

> and severity of the skin lesions.

>

> CONCLUSIONS: Our results on patients treated with TNF antagonists

> strongly support a link between TNF inhibition and IMSL development.

> Although these clinical complications are rare, clinicians should be

> aware of their occurrence and should recognize them.

>

>

> PMID: 19579151

>

> http://www.ncbi.nlm.nih.gov/pubmed/19579151

>

>

>

> Not an MD

>

[Guest guest]

Could it be a psoriasis plaque? You would expect them to lessen with Enbrel.

Kate f

Sent from my iPhone

On Jan 12, 2011, at 2:07 PM, " ktandtm " <ktandtm@...> wrote:

> What is weird for me is that I have a skin lesion on my stomach that cleared

up when I started Enbrel. Now that I have discontinued it for almost 3 weeks due

to being sick, it is coming back.

>

>

>

> ---

>

>

[Guest guest]

I showed it to a dermatologist and I can't remember what he called it but it

wasn't psoriasis. Who knows. LOL

>

> Could it be a psoriasis plaque? You would expect them to lessen with Enbrel.