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Vitamin D Level testing

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I have an apointment with a local RA specialist next week as I am working on a

location too far from my regular Rheumy to make an appt. This is considered a

specialist visit, and the blood work won't be covered under my copay as it will

be sent out to a lab. However, I am going to my PCP this week for various blood

tests (which are covered under my copay) and am asking him to include an ESR,

RF, ANA, CRP and Anti-ccp.

After reading in this blog for some time, I realize I should probably get a

Vitamin D level test, too. From what I can find, there are two - does anyone

have any recommendation as to which one (or both) I should ask for?

Thanks,

April

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April,

This is what osteoporosis expert Dr. Ott says about measuring

vitamin D status:

Measure 25(OH) vitamin D, NOT 1,25(OH)2 vitamin D

1,25(OH)2 vitamin D [1,25-D] is more difficult and expensive to

measure than 25(OH)D; moreover, it is not a good measure of vitamin D

status. When patients are vitamin D deficient, the parathyroid hormone

increases and drives the renal 1-alpha-hydroxylase, so that 1,25-D

levels increase. Only in severe deficiency, when substrate is

depleted, does the 1,25-D become low. Partially treated vitamin D

deficiency also results in marked elevations of 1,25-D levels.

Some doctors, thinking they are sophisticated because they know that

1,25-D is more active, order the wrong measurement. Do not fall into

this trap and waste money on this expensive but often misleading test!

There are only a few situations where you would actually want to know

the 1,25-D:

unexplained hypercalcemia (looking for granulomatous disease or lymphoma),

suspected genetic childhood rickets,

suspected tumor-induced osteomalacia,

some cases of nephrolithiasis or hypercalciuria.

Patients with stages 4-5 chronic kidney disease have decreased 1,25-D

levels but even in those patients the 25(OH) vitamin D is a better

test of the stores of vitamin D, and the PTH is a better indicator of

mineral abnormalities.

Finally, some cells generate intracellular 1,25-D to fight

tuberculosis, suppress cancer growth, or modify immune response. They

need adequate substrate, as measured by 25(OH) vitamin D.

http://courses.washington.edu/bonephys/opvitD.html

Not an MD

On Wed, Feb 16, 2011 at 9:42 AM, A <aftaylor5000@...> wrote:

> I have an apointment with a local RA specialist next week as I am working on a

location too far from my regular Rheumy to make an appt. This is considered a

specialist visit, and the blood work won't be covered under my copay as it will

be sent out to a lab.  However, I am going to my PCP this week for various blood

tests (which are covered under my copay) and am asking him to include an ESR,

RF, ANA, CRP and Anti-ccp.

> After reading in this blog for some time, I realize I should probably get a

Vitamin D level test, too.  From what I can find, there are two - does anyone

have any recommendation as to which one (or both) I should ask for?

>

> Thanks,

> April

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My PCP has always ordered simply " Vitamin D " test, and the lab report comes back

as 25 Hydroxy D3, 25 Hydroxy D2, and 25 Hydroxy D Total. Same thing when I had

the test done online by ZRT lab.

You might also ask for a test to measure homocysteine. High levels of

homocysteine are commonly found in patients with RA. The test determines if a

person has B12 or folate deficiency.

Jan

On Feb 16, 2011, at 10:42 AM, A wrote:

> I have an apointment with a local RA specialist next week as I am working on a

location too far from my regular Rheumy to make an appt. This is considered a

specialist visit, and the blood work won't be covered under my copay as it will

be sent out to a lab. However, I am going to my PCP this week for various blood

tests (which are covered under my copay) and am asking him to include an ESR,

RF, ANA, CRP and Anti-ccp.

> After reading in this blog for some time, I realize I should probably get a

Vitamin D level test, too. From what I can find, there are two - does anyone

have any recommendation as to which one (or both) I should ask for?

>

> Thanks,

> April

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