RESEARCH - The elaboration of the preliminary RA Impact of Disease (RAID) score: a EULAR initiative

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Ann Rheum Dis. Published Online First: 3 December 2008.

doi:10.1136/ard.2008.100271

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Extended Report

The elaboration of the preliminary Rheumatoid Arthritis Impact of

Disease (RAID) score: a EULAR initiative

Laure Gossec 1*, Maxime Dougados 1, Nathalie Rincheval 2, Andra

Balanescu 3, Dimitrios T Boumpas 4, Canadelo 5, Loreto Carmona

6, Jean-Pierre Daurès 2, Marten de Wit 5, Ben A C Dijkmans 7, Matthias

Englbrecht 8, Zafer Gunendi 9, Turid Heiberg 10, Kirwan 11,

Emilio Mola 12, Marco Matucci Cerinic 13, Kati Otsa 14, Georg

Schett 8, Tuulikki Sokka 15, A Wells 16, Gerd Aanerud 10,

Antonella Celano 13, Aiki Dudkin 14, Cristina 12, Katerina

Koutsogianni 4, F Nilgun Akca 9, Ana- Petre 3, Pamela s

11, Marieke Scholte-Voshaar 7, le von Krause 1 and Tore K Kvien

17

1 Paris Descartes University, Medicine Faculty; UPRES-EA 4058 ; APHP,

Rheumatology B, Cochin, France

2 Epidemiology and Statistics Department, Montpellier Medicine

Faculty, Montpellier, France

3 Research Center of Rheumatic Diseases, " Sf. " Hospital,

University of Bucharest, Romania

4 Rheumatology, Clinical Immunology and Allergy, University of Crete,

Faculty of Medicine, Heraklion, Greece

5 EULAR standing committee of People with Arthritis/Rheumatism in

Europe (PARE), Zurich, Switzerland

6 Research Unit, Spanish Foundation of Rheumatology, Madrid, Spain

7 Rheumatology, VU University medical center and Jan van Breemen

Institute, Netherlands

8 Department of Internal Medicine 3, University of Erlangen-Nuremberg,

Erlangen, Germany

9 University of Gazi, Department of Physical Medicine and

Rehabilitation, Division of Rheumatology, Turkey

10 Dept for Research and Education Ulleval University Hospital, Oslo, Norway

11 University of Bristol, Academic Rheumatology Unit, Bristol Royal

Infirmary, Bristol, United Kingdom

12 Rheumatology Department, Hospital Universitario La Paz, Madrid, Spain

13 Dept of Medicine, Division of Rheumatology AOUC, Denothe Centre,

University of Florence, Firenze, Italy

14 Rheumatology Department, Tallinn Central Hospital, Estonia

15 Jyväskylä Central Hospital, Jyväskylä, Finland

16 University of Ottawa Heart Institute, Ottawa, Ontario, Canada

17 Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway

Abstract

Background: Current response criteria in rheumatoid arthritis (RA)

usually assess only 3 patient-reported outcomes (PROs): pain,

functional disability and patient global assessment. Other important

PROs, such as fatigue, are not included.

Objective: To elaborate a patient-derived composite response index for

use in clinical trials in RA, the RA Impact of Disease (RAID) score.

Methods: Ten patients identified 17 domains or areas of health

relevant for inclusion into the score, then 96 patients (10 per

country in 10 European countries) ranked these domains in order of

decreasing importance. The 7 most important domains were selected.

Instruments were chosen for each domain, after extensive literature

research of psychometric properties and expert opinion. Relative

weight of each of the domains was obtained from 505 patients who were

asked to " distribute 100 points " among the 7 domains. The average

ranks of importance of these domains were then computed.

Results: The preliminary RAID score includes 7 domains, with the

following relative weights: pain (21%), functional disability (16%),

fatigue (15%), emotional well-being (12%), sleep (12%), coping (12%),

and physical well-being (12%). Weights were similar across countries,

and across patient and disease characteristics. Proposed instruments

include the Health Assessment Questionnaire and numeric ratings

scales.

Conclusion: The RAID score is a patient-derived weighted score to

assess the impact of RA. An ongoing study will allow final choice of

questionnaires and assessment of validity. This score can be used in

clinical trials as a new composite index that captures information

relevant for the patients.

http://ard.bmj.com/cgi/content/abstract/ard.2008.100271v1?papetoc

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