RESEARCH - Population-based study of autoimmune conditions and the risk of lymphoid malignancies

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Int J Cancer. 2009 Jan 22;125(2):398-405.

Population-based study of autoimmune conditions and the risk of

specific lymphoid malignancies.

LA, Gadalla S, Morton LM, Landgren O, Pfeiffer R, Warren JL,

Berndt SI, Ricker W, Parsons R, Engels EA.

Division of Cancer Epidemiology and Genetics, National Cancer

Institute, Bethesda, MD.

Some autoimmune conditions are associated with increased risk of

lymphoid malignancies, but information on specific malignancy subtypes

is limited. From the U.S. Surveillance Epidemiology and End

Results-Medicare database, we selected 44,350 lymphoid malignancy

cases (>/=67 years) and 122,531 population-based controls. Logistic

regression was used to derive odds ratios (ORs) comparing the

prevalence of autoimmune conditions in cases and controls, by lymphoid

malignancy subtype, adjusted for gender, age at malignancy/selection,

year of malignancy/selection, race and number of physician claims. The

strongest associations observed by non-Hodgkin lymphoma (NHL) subtypes

were diffuse large B-cell lymphoma with rheumatoid arthritis (OR 1.4,

95%CI 1.2-1.5) and Sjögren syndrome (2.0, 1.5-2.8); T-cell lymphoma

with hemolytic anemia (9.7, 4.3-22), psoriasis (3.1, 2.5-4.0), discoid

lupus erythematosus (4.4, 2.3-8.4) and celiac disease (5.0, 2.4-14.);

and marginal zone lymphoma with Sjögren syndrome (6.6, 4.6-9.5),

systemic lupus erythematosus (2.8, 1.7-4.7) and hemolytic anemia (7.4,

3.1-18). Hodgkin lymphoma was associated with systemic lupus

erythematosus (3.5, 1.9-6.7). Multiple myeloma was associated only

with pernicious anemia (1.5, 1.3-1.7). Several autoimmune conditions

were associated with increased risk of lymphoid neoplasms, especially

NHLs of diffuse large B-cell, marginal zone and T-cell subtypes. These

results support a mechanism whereby chronic antigenic stimulation

leads to lymphoid malignancy. Published 2009 UICC.

PMID: 19365835

http://www.ncbi.nlm.nih.gov/pubmed/19365835

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