REVIEW - Molecular therapies for SLE: clinical trials and future prospects

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Molecular Therapies for Systemic Lupus Erythematosus: Clinical Trials

and Future Prospects

Fanny Monneaux; Sylviane Muller

Posted: 29 Jan 2010; Arthritis Research & Therapy. 2009;11(3) © 2009

BioMed Central, Ltd.

Abstract

The prognosis of patients with systemic lupus erythematosus has

greatly improved since treatment regimens combining corticosteroids

and immunosuppressive medications have been widely adopted in

therapeutic strategies given to these patients. Immune suppression is

evidently efficient but also leads to higher susceptibility to

infectious and malignant diseases. Toxic effects and sometimes

unexpectedly dramatic complications of current therapies have been

progressively reported. Identifying novel molecular targets therefore

remains an important issue in the treatment of lupus. The aim of this

review article is to highlight emerging pharmacological options and

new therapeutic avenues for lupus with a particular focus on

non-antibody molecular strategies.

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Read the full review here:

http://www.medscape.com/viewarticle/715153

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