REVIEW - Dietary antioxidants in inflammatory arthritis: do they have any role in etiology or therapy?

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Nat Clin Pract Rheumatol. 2008 Nov;4(11):590-6. Epub 2008 Sep 30.

Dietary antioxidants in inflammatory arthritis: do they have any role

in etiology or therapy?

Pattison DJ, Winyard PG.

Bone and Joint Health at the Royal Cornwall Hospitals NHS Trust,

Truro, Cornwall, UK.

Rheumatoid arthritis is an autoimmune-mediated inflammatory disease of

unknown etiology, and is characterized by joint pain and soft-tissue

swelling. The role of dietary antioxidants in the prevention and

amelioration of symptoms in inflammatory joint disease has been of

interest for many years. Epidemiological studies provide evidence of a

link between dietary antioxidant intake and the likelihood of

developing inflammatory arthritis. Interventional studies of

antioxidant supplementation in established disease have been

inconclusive overall; however, the quality of such studies has often

been poor. The pathways by which antioxidant compounds might act are

now better understood. In this Review, we explore not only some of the

accepted mechanisms of antioxidant function but also outline some

concepts that could aid further investigation of the potential

therapeutic role of dietary antioxidants in inflammatory arthritis.

PMID: 18825134

http://www.ncbi.nlm.nih.gov/pubmed/18825134

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