Matija - Nasalcrom

[Guest guest]

Hi Matija,

Concerning the effect of nasalcrom on decreasing redness and flushing of your

nose. cea is quite complex. There can be literally hundreds of

instigators. Sympathetic nerves, sensory nerves, mast cells, immune cells,

damaged vessels, increased number of vessels, damaged skin barrier.........

However, it seems that mast cells may be slightly abnormal in some rosacea

patients -- they are finding increased numbers of cells in some biopsies as well

as increased activity of mast cells in others (via tryptase analysis). Mast

cells are one of the most potent sources of inflammatory mediators in the facial

skin. Futhermore, they are intimately involved in most nasal problems and

allergic reactions. In addition, the substances that they release can activate

nerves which can then release other inflammatory mediators -- it can be a

viscous cycle. If you block mast cell release of these substances, you may

decrease the overall inflammatory response.

Nasalcrom only stabilizes mast cells in your nasal passages and not on the

external portion of your nose. However, sometimes the instigating factor begins

inside the nasal passage. If the inflammation is severe enough within the nasal

passage, it may affect parts of the external nose (due to conducted vasodilation

and recruitment of different nerve types). Thus, if you are able to stop the

'nasal flare', you might lessen the 'red nose'. I think that you have mentioned

that nasalcrom is indeed helping your nose -- great!

But, this should have no effect on your cheeks -- too far away (different

branches of blood vessels and different segments of nerves).

Got to run,

Hope this helps some?

Geoffrey

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Dr. Geoffrey Nase, PhD

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