RESEARCH - All NSAIDs have cardiovascular risks

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All Nonsteroidal Anti-Inflammatory Drugs Have Cardiovascular Risks

Gandey

Medscape

January 12, 2011 — New data showing nonsteroidal anti-inflammatory

drugs (NSAIDs) have cardiovascular risks are putting the well-known

pain relievers back in the headlines. Investigators evaluating

available evidence report they have found little to suggest that any

of the investigated options are safe.

Regulatory agencies have already pointed to cardiovascular signals

with NSAIDs, but these concerns are based mainly on observational

evidence. This new study provides a comprehensive analysis of all

randomized controlled trials of the drugs.

During an interview with Medscape Medical News, senior investigator

Jüni, MD, from the University of Bern in Switzerland, said his

team expected to see an increased risk but was surprised by the

magnitude of the signal. " We never thought we'd see 2- and 4-fold

increased risks, " he said. " The doses were admittedly high, " he

pointed out, " however, this is clearly clinically relevant. "

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Read the whole article here:

http://www.medscape.com/viewarticle/735672

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