RESEARCH - Outcome of surgical management of bisphosphonate-related osteonecrosis of the jaws: review of 33 surgical cases

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J Oral Maxillofac Surg. 2009 May;67(5):943-50.

Outcome of surgical management of bisphosphonate-related osteonecrosis

of the jaws: review of 33 surgical cases.

Stanton DC, Balasanian E.

Department of Oral and Maxillofacial Surgery, University of

Pennsylvania Health System and School of Dental Medicine,

Philadelphia, PA 19104, USA.

PURPOSE: We describe our experience with surgical management of

bisphosphonate-related osteonecrosis of the jaws (BRONJ). MATERIALS

AND METHODS: The data included 33 BRONJ cases treated surgically by a

single surgeon at the Hospital of the University of Pennsylvania.

RESULTS: Of the 30 debridement patients, 25 (including 1

sequestrectomy patient who required formal debridement) healed

completely. Of the 30 patients who underwent surgical debridement, 18

healed following this initial treatment and remained healed. Of the 4

patients requiring sequestrectomy, 3 healed after the initial

treatment. Thus, 28 of 33 patients healed completely with complete

mucosal coverage and elimination of pain. Four patients developed

occurrence of BRONJ at a separate site. All 4 patients were treated

with our surgery protocol and remain healed. Thus, 32 of 37 BRONJ

occurrences have healed with our surgical debridement protocol or

sequestrectomy. The follow-up range was 1 to 40 months (average 10.7).

CONCLUSIONS: The results of our case series have shown that surgical

debridement can be successful in treating BRONJ.

PMID: 19375001

http://www.ncbi.nlm.nih.gov/pubmed/19375001

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