REVIEW - Unraveling the genetics of complex diseases. Susceptibility genes for RA and psoriasis

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Semin Immunol. 2009 May 13.

Unraveling the genetics of complex diseases: Susceptibility genes for

rheumatoid arthritis and psoriasis.

Li Y, Begovich AB.

Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA.

Talk of numerous genetic risk factors for rheumatoid arthritis (RA)

and psoriasis has been percolating for years, but with the exception

of the human leukocyte antigen (HLA) region, none have been

definitively identified. Recently the results of multiple, well

powered, genetic case-control studies have begun to appear providing

convincing statistical evidence for at least ten non-HLA related risk

genes or loci (C5/TRAF1, CD40, CTLA4, KIF5A/PIP4K2C, MMEL1/TNFRSF14,

PADI4, PRKCQ, PTPN22, STAT4, and TNFAIP3/OLIG3) for RA and six (IL12B,

IL13, IL23R, STAT2/IL23A, TNFAIP3, and TNIP1) for psoriasis. These

initial, novel findings are beginning to shed light on the molecular

pathways pertinent to the individual diseases and highlight the

pleiotropic effects of several risk factors as well as the allelic

heterogeneity underlying susceptibility to these and other autoimmune

diseases.

PMID: 19446472

http://www.ncbi.nlm.nih.gov/pubmed/19446472

Not an MD