Re: RESEARCH - Cumulative childhood stress and autoimmune diseases in adults

[Guest guest]

Ok , I'm going to have to sign up for more stats to fight this one

How about this-

Out of the 15k+ subjects the majority of them would be expected to report at

least 1 ACR given how broadly ACE was defined (eg divorce). Then the occurance

of autoimmune diseases was defined by having any of 21 conditions. I need more

technical help but can I object by saying the number of subjects with 0 ACE is

too low?help! Kate f

Sent from my iPhone

On Jul 10, 2009, at 3:20 PM,

<Rheumatoid.Arthritis.Support@...> wrote:

Psychosom Med. 2009 Feb;71(2):243-50. Epub 2009 Feb 2.

Cumulative childhood stress and autoimmune diseases in adults.

Dube SR, Fairweather D, Pearson WS, Felitti VJ, Anda RF, Croft JB.

Centers for Disease Control and Prevention, National Center for

Chronic Disease Prevention and Health Promotion, Division of Adult and

Community Health, 4770 Buford Highway, N.E., MS K-50, Atlanta, GA

30341-3717, USA.

OBJECTIVE: To examine whether childhood traumatic stress increased the

risk of developing autoimmune diseases as an adult.

METHODS: Retrospective cohort study of 15,357 adult health maintenance

organization members enrolled in the Adverse Childhood Experiences

(ACEs) Study from 1995 to 1997 in San Diego, California, and eligible

for follow-up through 2005. ACEs included childhood physical,

emotional, or sexual abuse; witnessing domestic violence; growing up

with household substance abuse, mental illness, parental divorce,

and/or an incarcerated household member. The total number of ACEs (ACE

Score range = 0-8) was used as a measure of cumulative childhood

stress. The outcome was hospitalizations for any of 21 selected

autoimmune diseases and 4 immunopathology groupings: T- helper 1 (Th1)

(e.g., idiopathic myocarditis); T-helper 2 (Th2) (e.g., myasthenia

gravis); Th2 rheumatic (e.g., rheumatoid arthritis); and mixed Th1/Th2

(e.g., autoimmune hemolytic anemia).

RESULTS: Sixty-four percent reported at least one ACE. The event rate

(per 10,000 person-years) for a first hospitalization with any

autoimmune disease was 31.4 in women and 34.4 in men. First

hospitalizations for any autoimmune disease increased with increasing

number of ACEs (p < .05). Compared with persons with no ACEs, persons

with >or=2 ACEs were at a 70% increased risk for hospitalizations with

Th1, 80% increased risk for Th2, and 100% increased risk for rheumatic

diseases (p < .05).

CONCLUSIONS: Childhood traumatic stress increased the likelihood of

hospitalization with a diagnosed autoimmune disease decades into

adulthood. These findings are consistent with recent biological

studies on the impact of early life stress on subsequent inflammatory

responses.

PMID: 19188532

http://www.ncbi.nlm.nih.gov/pubmed/19188532

Not an MD

[Guest guest]

Go ahead and object, Kate. LOL.

I'm not sure it's a terrific study. I couldn't find much recent

research on the topic.

Not an MD

On Fri, Jul 10, 2009 at 3:40 PM, Kate Fair<kalfoley@...> wrote:

> Ok , I'm going to have to sign up for more stats to fight this one

> How about this-

> Out of the 15k+ subjects the majority of them would be expected to report at

least 1 ACR given how broadly ACE was defined (eg divorce). Then the occurance

of autoimmune diseases was defined by having any of 21 conditions. I need more

technical help but can I object by saying the number of subjects with 0 ACE is

too low?help! Kate f

[Guest guest]

Oooh I have another idea, people who are sick are mire likely to wonder how they

came to have a given disease and would be more likely to recall negative life

events and even attribute those life events to the origins of their disease

state. Plus sick people are more likely to be depressed and depressed people

tend to recount higher negative life events bc of the way depression Affects

memory ie negative memories are more eAsily accessed in a sad mood state.

Kate f

Sent from my iPhone

On Jul 10, 2009, at 3:45 PM,

<Rheumatoid.Arthritis.Support@...> wrote:

Go ahead and object, Kate. LOL.

I'm not sure it's a terrific study. I couldn't find much recent

research on the topic.

Not an MD

On Fri, Jul 10, 2009 at 3:40 PM, Kate Fair<kalfoley@...> wrote:

> Ok , I'm going to have to sign up for more stats to fight this one

> How about this-

> Out of the 15k+ subjects the majority of them would be expected to report at

least 1 ACR given how broadly ACE was defined (eg divorce). Then the occurance

of autoimmune diseases was defined by having any of 21 conditions. I need more

technical help but can I object by saying the number of subjects with 0 ACE is

too low?help! Kate f

[Guest guest]

Perhaps a autiimmune disease is more likely to be identified based on an

increased level of seeing medical professionals.

Stan

Subject: [ ] RESEARCH - Cumulative childhood stress and autoimmune

diseases in  adults

Psychosom Med. 2009 Feb;71(2):243-50. Epub 2009 Feb 2.

Cumulative childhood stress and autoimmune diseases in adults.

[Guest guest]

So you do not believe depression can result in poor health issues. DO NOT answer

from your iPhone (lol).

Stan

Subject: Re: [ ] RESEARCH - Cumulative childhood stress and

 autoimmune diseases in adults

Oooh I have another idea, people who are sick are mire likely to wonder how they

came to have a given disease and would be more likely to recall negative life

events and even attribute those life events to the origins of their disease

state. Plus sick people are more likely to be depressed and depressed people

tend to recount higher negative life events bc of the way depression Affects

memory ie negative memories are more eAsily accessed in a sad mood state.  

Kate f

Sent from my iPhone

On Jul 10, 2009, at 3:45 PM,

<Rheumatoid.Arthritis.Support@...> wrote:

Go ahead and object, Kate. LOL.

I'm not sure it's a terrific study. I couldn't find much recent

research on the topic.

Not an MD

On Fri, Jul 10, 2009 at 3:40 PM, Kate Fair<kalfoley@...> wrote:

> Ok , I'm going to have to sign up for more stats to fight this one

> How about this-

> Out of the 15k+ subjects the majority of them would be expected to report at

least 1 ACR given how broadly ACE was defined (eg divorce). Then the occurance

of autoimmune diseases was defined by having any of 21 conditions. I need more

technical help but can I object by saying the number of subjects with 0 ACE is

too low?help! Kate f

[Guest guest]

I have no choice Stan, it's implanted in my hand we r actually in chicago

this wknd for family stuff so lots of time in the car .

I grudgingly agree that depression can help compromise the immune system and

leave one more vulnerable to infectious disease. I Heartily agree that

depression has a physical component that might be headaches, body aches, neuro

sx etc. I just have issues with stress or trauma being some kind of causal agent

that made us sick. Even tho my childhood was a nightmare, I guess linking that

to my immune system dysfunction makes me feel like a victim and I'm way too mu h

of a tough cookie for that! Huggies, K

On Jul 10, 2009, at 5:42 PM, stanpfister@... wrote:

So you do not believe depression can result in poor health issues. DO NOT answer

from your iPhone (lol).

Stan

Subject: Re: [ ] RESEARCH - Cumulative childhood stress and autoimmune

diseases in adults

Oooh I have another idea, people who are sick are mire likely to wonder how they

came to have a given disease and would be more likely to recall negative life

events and even attribute those life events to the origins of their disease

state. Plus sick people are more likely to be depressed and depressed people

tend to recount higher negative life events bc of the way depression Affects

memory ie negative memories are more eAsily accessed in a sad mood state.

Kate f

Sent from my iPhone

On Jul 10, 2009, at 3:45 PM,

<Rheumatoid.Arthritis.Support@...> wrote:

Go ahead and object, Kate. LOL.

I'm not sure it's a terrific study. I couldn't find much recent

research on the topic.

Not an MD

On Fri, Jul 10, 2009 at 3:40 PM, Kate Fair<kalfoley@...> wrote:

> Ok , I'm going to have to sign up for more stats to fight this one

> How about this-

> Out of the 15k+ subjects the majority of them would be expected to report at

least 1 ACR given how broadly ACE was defined (eg divorce). Then the occurance

of autoimmune diseases was defined by having any of 21 conditions. I need more

technical help but can I object by saying the number of subjects with 0 ACE is

too low?help! Kate f

[Guest guest]

Kate, I think we all like to assign blame. For example, if I have a

symptom, I might blame the RA, when it in fact has nothing to do with

the symptom. But I like to know why.

Sue

On Jul 10, 2009, at 4:57 PM, Kate Fair wrote:

> Oooh I have another idea, people who are sick are mire likely to

> wonder how they came to have a given disease and would be more

> likely to recall negative life events and even attribute those life

> events to the origins of their disease state. Plus sick people are

> more likely to be depressed and depressed people tend to recount

> higher negative life events bc of the way depression Affects memory

> ie negative memories are more eAsily accessed in a sad mood state.

[Guest guest]

That's okay, I was just kidding. I'm not a gadget person. I have a primary desk

top, a secondary desk top, two lap top computers, an 80 gig iPod, a digital

camera, a playstation II, and I just got a new cell phone for my upcoming

birthday. Just got my wifi installed at my house and I'm considering the options

at the girlfriend's place. Xbod or playstation, both do use wifi. All these

things must be updated and maintained. Not that I'm a gadget person but have you

seen the new 7 " battery powered HD televisions? Not that the tlevisions I have

in front and behind me matter, I might need one of them new ones for my desk!

The point is that depression can lead to shopping, thank god, and I tied it all

together nicely.

Stan

Seattle, dark.

Re: [ ] RESEARCH - Cumulative childhood stress and autoimmune

diseases in adults

I have no choice Stan, it's implanted in my hand we r actually in chicago

this wknd for family stuff so lots of time in the car .

I grudgingly agree that depression can help compromise the immune system and

leave one more vulnerable to infectious disease. I Heartily agree that

depression has a physical component that might be headaches, body aches, neuro

sx etc. I just have issues with stress or trauma being some kind of causal agent

that made us sick. Even tho my childhood was a nightmare, I guess linking that

to my immune system dysfunction makes me feel like a victim and I'm way too mu h

of a tough cookie for that! Huggies, K

On Jul 10, 2009, at 5:42 PM, stanpfister@... wrote:

So you do not believe depression can result in poor health issues. DO NOT answer

from your iPhone (lol).

Stan