RESEARCH - Citrulline dependence of anti-CCP antibodies in SLE as a marker of deforming/erosive arthritis

[Guest guest]

J Rheumatol. 2009 Nov 2.

Citrulline Dependence of Anti-Cyclic Citrullinated Peptide Antibodies

in Systemic Lupus Erythematosus as a Marker of Deforming/Erosive

Arthritis.

Kakumanu P, Sobel ES, Narain S, Li Y, Akaogi J, Yamasaki Y, Segal MS,

Hahn PC, Chan EK, Reeves WH, Satoh M.

From the the Division of Rheumatology and Clinical Immunology,

Department of Medicine; Department of Pathology, Immunology, and

Laboratory Medicine; Division of Nephrology, Department of Medicine;

and Department of Oral Biology, University of Florida, Gainesville,

Florida, USA.

OBJECTIVE: Anti-cyclic citrullinated peptide (CCP) antibodies are a

serological marker for rheumatoid arthritis (RA); up to 10%-15% of

patients with systemic lupus erythematosus (SLE) are also positive.

While anti-CCP in RA is citrulline-dependent, anti-CCP in some other

diseases is citrulline-independent and reacts with both CCP and the

unmodified (arginine-containing) cyclic arginine peptide (CAP). We

investigated the citrulline dependence of anti-CCP and its

significance in the arthritis of SLE.

METHODS: IgG anti-CCP was compared by ELISA to anti-CAP in sera from

patients with SLE (n = 335) and RA (n = 47) and healthy controls (n =

35). SLE patients were divided into 5 groups based on their joint

involvement: subset I: deforming/erosive arthritis (n = 20); II:

arthritis fulfilling (or likely fulfilling) American College of

Rheumatology criteria for RA but without erosions (n = 18); III: joint

swelling but not fulfilling RA criteria (n = 39); IV: arthritis

without documented joint swelling (n = 194); and V: no arthritis (n =

58).

RESULTS: Anti-CCP (> 1.7 units) was found in 68% (32/47) of patients

with RA and 17% (55/329) of those with SLE. It was more common in SLE

patients with deforming/erosive arthritis (38%). High anti-CCP (> 10

units) was found in RA (26%) and deforming/erosive SLE (12%). High

anti- CCP/CAP ratios (> 2, indicating a selectivity to CCP) were found

in 91% of anti-CCP-positive RA and 50% of anti-CCP-positive SLE

patients with deforming/erosive arthritis. Patients from subset II did

not have high anti-CCP/CAP.

CONCLUSION: Citrulline dependence or high levels (> 10) of anti-CCP

were common in SLE patients with deforming/erosive arthritis, while

most anti-CCP in SLE patients was citrulline-independent. This may be

useful in identifying a subset of SLE patients with high risk for

development of deforming/erosive arthritis.

PMID: 19884269

http://www.ncbi.nlm.nih.gov/pubmed/19884269

Not an MD

[Guest guest]

Good morning

I found this article very interesting this morning.  No wonder I always felt so

much worse after eating watermelon.  I had to read about citrulline again at

www.wikipedia.com.

I try to understand what the article is saying, but the more I read it, the more

I become confused.  It seems to me that ammonia, which has something to do with

our liver, has something to do with RA.  One sentence that sparks my interest

read that patients with RA often have detectable antibodies against proteins

containing citrulline. " against proteins " - I don't understand that.   I also

read about citrullination.  If you or anyone in this group reads about this, I

would be interested in knowing what you think.

Thank you and take care.

(musiclvr3237)

From: <Rheumatoid.Arthritis.Support@...>

Subject: [ ] RESEARCH - Citrulline dependence of anti-CCP antibodies in

SLE as a marker of deforming/erosive arthritis

" " < >

Date: Sunday, November 8, 2009, 10:06 AM

 

J Rheumatol. 2009 Nov 2.

Citrulline Dependence of Anti-Cyclic Citrullinated Peptide Antibodies

in Systemic Lupus Erythematosus as a Marker of Deforming/Erosive

Arthritis.

Kakumanu P, Sobel ES, Narain S, Li Y, Akaogi J, Yamasaki Y, Segal MS,

Hahn PC, Chan EK, Reeves WH, Satoh M.

From the the Division of Rheumatology and Clinical Immunology,

Department of Medicine; Department of Pathology, Immunology, and

Laboratory Medicine; Division of Nephrology, Department of Medicine;

and Department of Oral Biology, University of Florida, Gainesville,

Florida, USA.

OBJECTIVE: Anti-cyclic citrullinated peptide (CCP) antibodies are a

serological marker for rheumatoid arthritis (RA); up to 10%-15% of

patients with systemic lupus erythematosus (SLE) are also positive.

While anti-CCP in RA is citrulline-dependen t, anti-CCP in some other

diseases is citrulline-independ ent and reacts with both CCP and the

unmodified (arginine-containin g) cyclic arginine peptide (CAP). We

investigated the citrulline dependence of anti-CCP and its

significance in the arthritis of SLE.

METHODS: IgG anti-CCP was compared by ELISA to anti-CAP in sera from

patients with SLE (n = 335) and RA (n = 47) and healthy controls (n =

35). SLE patients were divided into 5 groups based on their joint

involvement: subset I: deforming/erosive arthritis (n = 20); II:

arthritis fulfilling (or likely fulfilling) American College of

Rheumatology criteria for RA but without erosions (n = 18); III: joint

swelling but not fulfilling RA criteria (n = 39); IV: arthritis

without documented joint swelling (n = 194); and V: no arthritis (n =

58).

RESULTS: Anti-CCP (> 1.7 units) was found in 68% (32/47) of patients

with RA and 17% (55/329) of those with SLE. It was more common in SLE

patients with deforming/erosive arthritis (38%). High anti-CCP (> 10

units) was found in RA (26%) and deforming/erosive SLE (12%). High

anti- CCP/CAP ratios (> 2, indicating a selectivity to CCP) were found

in 91% of anti-CCP-positive RA and 50% of anti-CCP-positive SLE

patients with deforming/erosive arthritis. Patients from subset II did

not have high anti-CCP/CAP.

CONCLUSION: Citrulline dependence or high levels (> 10) of anti-CCP

were common in SLE patients with deforming/erosive arthritis, while

most anti-CCP in SLE patients was citrulline-independ ent. This may be

useful in identifying a subset of SLE patients with high risk for

development of deforming/erosive arthritis.

PMID: 19884269

http://www.ncbi. nlm.nih.gov/ pubmed/19884269

Not an MD

[Guest guest]

Hi, . I'm not sure what you are asking. Could you rephrase your question?

Not an MD

On Mon, Nov 9, 2009 at 8:56 AM, (musiclvr) <musiclvr3237@...> wrote:

> Good morning

> I found this article very interesting this morning.  No wonder I always felt

so much worse after eating watermelon.  I had to read about citrulline again at

www.wikipedia.com.

> I try to understand what the article is saying, but the more I read it, the

more I become confused.  It seems to me that ammonia, which has something to do

with our liver, has something to do with RA.  One sentence that sparks my

interest read that patients with RA often have detectable antibodies against

proteins containing citrulline. " against proteins " - I don't understand that. 

 I also read about citrullination.  If you or anyone in this group reads about

this, I would be interested in knowing what you think.

> Thank you and take care.

> (musiclvr3237)