Re: REVIEW - Epstein-Barr virus in autoimmune diseases

[Guest guest]

Very interesting article, . I've had family members question where

I could have gotten my RA from as they claimed they never knew of

anyone else in the family that had that. BUT, my mother had EBV (among

other things). I also read somewhere a long time ago that it is

contagious. Do you know if they still say that?

Thanks.....Doreen

>

> Best Pract Res Clin Rheumatol. 2008 Oct;22(5):883-96.

>

> Epstein-Barr virus in autoimmune diseases.

>

> Toussirot E, Roudier J. Department of Rheumatology, University

> Hospital Minjoz, Besançon; and EA 3186 Agents Pathogènes et

> Inflammation, University of Franche Comté, Besançon, France.

>

> Autoimmune diseases such as systemic lupus erythematosus (SLE),

> rheumatoid arthritis (RA), and primary Sjögren's syndrome (pSS) are

> complex disorders with a genetic background and the involvement of

> environmental factors, including viruses. The Epstein-Barr virus

> (EBV)is a plausible candidate for playing a role in the

> pathophysiology of these diseases. Both SLE and RA are

> characterized by high titers of anti-EBV antibodies and impaired

> T-cell responses to EBV antigens. Compared with normal subjects,

> elevated EBV load in peripheral blood has been observed in SLE and

> RA. EBV DNA or RNA has been evidenced in target organs of RA

> (synovium) or pSS (salivary glands). Finally, molecular mimicry has

> been demonstrated between EBV proteins and self antigens in these

> three conditions. In addition, SLE, RA, and pSS are associated with

> an increased risk of lymphoma with a potential role for EBV. The

> influence of new and emergent treatments of these autoimmune

> diseases (biological therapies) on EBV load and the course of

> latent EBV infection requires further studies.

>

> PMID: 19028369

>

> http://www.ncbi.nlm.nih.gov/pubmed/19028369

>

>

> Not an MD

[Guest guest]

I was diagnosed with EBV about 2.5 years prior to having RA symptoms

and then it was another year or so until diagnosed with RA.

Interesting.................

Pat

> >

> > Best Pract Res Clin Rheumatol. 2008 Oct;22(5):883-96.

> >

> > Epstein-Barr virus in autoimmune diseases.

> >

> > Toussirot E, Roudier J. Department of Rheumatology, University

> > Hospital Minjoz, Besançon; and EA 3186 Agents Pathogènes et

> > Inflammation, University of Franche Comté, Besançon, France.

> >

> > Autoimmune diseases such as systemic lupus erythematosus (SLE),

> > rheumatoid arthritis (RA), and primary Sjögren's syndrome (pSS) are

> > complex disorders with a genetic background and the involvement of

> > environmental factors, including viruses. The Epstein-Barr virus

> > (EBV)is a plausible candidate for playing a role in the

> > pathophysiology of these diseases. Both SLE and RA are

> > characterized by high titers of anti-EBV antibodies and impaired

> > T-cell responses to EBV antigens. Compared with normal subjects,

> > elevated EBV load in peripheral blood has been observed in SLE and

> > RA. EBV DNA or RNA has been evidenced in target organs of RA

> > (synovium) or pSS (salivary glands). Finally, molecular mimicry has

> > been demonstrated between EBV proteins and self antigens in these

> > three conditions. In addition, SLE, RA, and pSS are associated with

> > an increased risk of lymphoma with a potential role for EBV. The

> > influence of new and emergent treatments of these autoimmune

> > diseases (biological therapies) on EBV load and the course of

> > latent EBV infection requires further studies.

> >

> > PMID: 19028369

> >

> > http://www.ncbi.nlm.nih.gov/pubmed/19028369

> >

> >

> > Not an MD

>