RESEARCH - Role of PIGF and fit-1 in RA inflammation: a link between angiogenesis and inflammation

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Role of Placental Growth Factor and Its Receptor flt-1 in Rheumatoid

Inflammation: A Link Between Angiogenesis and Inflammation

Medscape

Posted 10 Mar 2009

Although the origin of rheumatoid arthritis (RA) remains unclear,

bioactive proteins known as cytokines, particularly TNFá and IL-6,

which are involved in inflammation, play a major role in the disease

by contributing to joint and tissue destruction. Placenta growth

factor (PIGF), another cytokine, has been thought to be critical for a

new blood vessel formation in the placenta to sufficiently deliver

oxygen and nutrients to fetus. A new study examined the effects of

PIGF on the inflammatory process of RA. The results suggest that PIGF

may play an important role in inflammation in RA joints. The study was

published in the February issue of Arthritis & Rheumatism

(http://www3.interscience.wiley.com/journal/76509746/home).

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Read the full article here:

http://www.medscape.com/viewarticle/588028

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